SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r3f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1r3f TRNA PSEUDOURIDINE
SYNTHASE B
(Escherichia
coli) 		6 / 12 GLY A 192
GLY A 188
ILE A 183
ASP A 186
LEU A 112
LEU A 158
 None
 1.33A 2nxeA-1r3fA:
2.1		 2nxeA-1r3fA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 1r3f TRNA PSEUDOURIDINE
SYNTHASE B
(Escherichia
coli) 		5 / 12 GLY A 177
TYR A  76
LEU A 200
VAL A 197
SER A  89
 None
 1.29A 2vqyA-1r3fA:
undetectable		 2vqyA-1r3fA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 1r3f TRNA PSEUDOURIDINE
SYNTHASE B
(Escherichia
coli) 		4 / 7 ASP A 250
SER A  72
SER A 175
ASP A 118
 None
 1.25A 3bc9A-1r3fA:
undetectable		 3bc9A-1r3fA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1r3f TRNA PSEUDOURIDINE
SYNTHASE B
(Escherichia
coli) 		6 / 12 GLY A 188
VAL A 101
ILE A 183
ASP A 186
LEU A 112
LEU A 158
 None
 1.49A 3cjtO-1r3fA:
undetectable		 3cjtO-1r3fA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 1r3f TRNA PSEUDOURIDINE
SYNTHASE B
(Escherichia
coli) 		4 / 5 ASP A 238
LEU A 237
ILE A 231
PRO A 232
 None
 1.19A 3s3vA-1r3fA:
undetectable		 3s3vA-1r3fA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 1r3f TRNA PSEUDOURIDINE
SYNTHASE B
(Escherichia
coli) 		4 / 5 THR A 284
GLY A 286
PRO A 257
ASN A 255
 None
 1.04A 3u8qA-1r3fA:
undetectable		 3u8qA-1r3fA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 1r3f TRNA PSEUDOURIDINE
SYNTHASE B
(Escherichia
coli) 		4 / 8 ASN A  37
GLY A   8
ASP A  10
PRO A 232
 None
 0.73A 4eyrB-1r3fA:
undetectable		 4eyrB-1r3fA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1r3f TRNA PSEUDOURIDINE
SYNTHASE B
(Escherichia
coli) 		4 / 8 LEU A 216
LEU A 219
TYR A  36
ILE A  57
 None
 0.82A 4lzrA-1r3fA:
undetectable		 4lzrA-1r3fA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 1r3f TRNA PSEUDOURIDINE
SYNTHASE B
(Escherichia
coli) 		5 / 12 GLY A 192
GLY A 194
GLY A 188
LEU A 187
GLY A  83
 None
 0.95A 4o33A-1r3fA:
undetectable		 4o33A-1r3fA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 1r3f TRNA PSEUDOURIDINE
SYNTHASE B
(Escherichia
coli) 		5 / 12 GLY A 192
GLY A 194
GLY A 188
LEU A 187
GLY A  83
 None
 0.87A 4o3fA-1r3fA:
undetectable		 4o3fA-1r3fA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1r3f TRNA PSEUDOURIDINE
SYNTHASE B
(Escherichia
coli) 		5 / 11 LEU A  82
GLU A 164
LEU A 168
ALA A 105
LEU A 108
 None
 1.01A 4wg0H-1r3fA:
undetectable
4wg0I-1r3fA:
undetectable
4wg0J-1r3fA:
undetectable		 4wg0H-1r3fA:
4.01
4wg0I-1r3fA:
4.01
4wg0J-1r3fA:
4.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1r3f TRNA PSEUDOURIDINE
SYNTHASE B
(Escherichia
coli) 		5 / 11 ALA A 105
LEU A 108
GLU A 164
LEU A 168
LEU A  82
 None
 1.01A 4wg0K-1r3fA:
undetectable
4wg0L-1r3fA:
undetectable
4wg0M-1r3fA:
undetectable		 4wg0K-1r3fA:
4.01
4wg0L-1r3fA:
4.01
4wg0M-1r3fA:
4.01