SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r44'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE
(Enterococcus
faecium) 		4 / 4 ARG A 147
ALA A 152
ALA A 160
GLU A 159
 None
 0.99A 1e7bA-1r44A:
undetectable		 1e7bA-1r44A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE
(Enterococcus
faecium) 		4 / 4 ARG A 147
ALA A 152
ALA A 160
GLU A 159
 None
 0.90A 1e7bB-1r44A:
undetectable		 1e7bB-1r44A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE
(Enterococcus
faecium) 		5 / 11 LEU A 124
TYR A 185
GLY A  63
ILE A 169
HIS A 150
 None
 1.22A 1p91A-1r44A:
undetectable		 1p91A-1r44A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE
(Enterococcus
faecium) 		5 / 11 GLY A 138
SER A 156
THR A  59
VAL A 135
PRO A 136
 None
 1.13A 2nnhA-1r44A:
undetectable		 2nnhA-1r44A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE
(Enterococcus
faecium) 		5 / 9 GLY A 138
SER A 156
THR A  59
VAL A 135
PRO A 136
 None
 1.12A 2nnhB-1r44A:
undetectable		 2nnhB-1r44A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE
(Enterococcus
faecium) 		3 / 3 LYS A   1
ARG A  39
VAL A  41
 None
 1.04A 2r2vC-1r44A:
0.0
2r2vD-1r44A:
0.0		 2r2vC-1r44A:
11.70
2r2vD-1r44A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE
(Enterococcus
faecium) 		5 / 12 MET A 170
LEU A 166
LEU A  66
ILE A 122
ALA A 121
 None
 1.02A 3a50D-1r44A:
undetectable		 3a50D-1r44A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE
(Enterococcus
faecium) 		5 / 12 PHE A 197
GLY A  42
ASP A 123
ILE A 122
LEU A  46
 None
None
ZN  A 203 (-2.5A)
None
None
 1.30A 3iv6A-1r44A:
undetectable		 3iv6A-1r44A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH201_1
(PROTEIN S100-A4)		 1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE
(Enterococcus
faecium) 		5 / 9 ILE A   3
MET A   1
PRO A 200
PHE A 197
GLY A 119
 None
 1.29A 3ko0H-1r44A:
undetectable
3ko0I-1r44A:
undetectable		 3ko0H-1r44A:
20.69
3ko0I-1r44A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE
(Enterococcus
faecium) 		4 / 7 TYR A  70
ASP A  33
ALA A  75
TYR A  35
 None
 1.14A 3rodD-1r44A:
undetectable		 3rodD-1r44A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE
(Enterococcus
faecium) 		3 / 3 ARG A 163
ARG A 167
ILE A 155
 None
 0.70A 4b7qA-1r44A:
undetectable		 4b7qA-1r44A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE
(Enterococcus
faecium) 		3 / 3 ARG A 163
ARG A 167
ILE A 155
 None
 0.77A 4b7qC-1r44A:
undetectable		 4b7qC-1r44A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE
(Enterococcus
faecium) 		3 / 3 HIS A 184
TRP A 182
SER A 115
 ZN  A 203 (-3.5A)
None
None
 1.05A 4lrhD-1r44A:
undetectable		 4lrhD-1r44A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE
(Enterococcus
faecium) 		4 / 7 ALA A  53
ILE A 122
LEU A 187
PHE A 175
 None
 1.01A 4uymA-1r44A:
0.0		 4uymA-1r44A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE
(Enterococcus
faecium) 		4 / 6 LEU A 124
LEU A 126
ILE A 169
MET A 170
 None
 0.95A 4ww7A-1r44A:
0.0		 4ww7A-1r44A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE
(Enterococcus
faecium) 		5 / 10 ASP A 142
VAL A  32
TYR A  35
TYR A  21
GLY A  29
 None
 1.39A 4xpbA-1r44A:
undetectable		 4xpbA-1r44A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE
(Enterococcus
faecium) 		5 / 12 TYR A 127
LEU A  50
PHE A 175
GLY A 174
THR A 125
 None
 1.32A 4ze1A-1r44A:
undetectable		 4ze1A-1r44A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE
(Enterococcus
faecium) 		4 / 8 VAL A  15
ASP A   9
GLY A  42
LEU A  46
 None
 0.87A 5w3jB-1r44A:
undetectable		 5w3jB-1r44A:
19.52