SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r47'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens) 		3 / 3 ALA A 370
VAL A 376
TRP A 349
 None
 1.02A 1gmkC-1r47A:
undetectable
1gmkD-1r47A:
undetectable		 1gmkC-1r47A:
4.24
1gmkD-1r47A:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens) 		5 / 12 LEU A 131
LEU A 129
ALA A  84
VAL A 124
MET A  76
 None
 1.36A 1kt4A-1r47A:
undetectable		 1kt4A-1r47A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens) 		5 / 11 LEU A 131
LEU A 129
ALA A  84
VAL A 124
MET A  76
 None
 1.41A 1kt6A-1r47A:
undetectable		 1kt6A-1r47A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens) 		5 / 11 LEU A 131
LEU A 129
ALA A  84
VAL A 124
MET A  76
 None
 1.41A 1kt7A-1r47A:
undetectable		 1kt7A-1r47A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens) 		4 / 8 ASP A 155
PHE A 159
GLY A 147
ASP A 136
 None
 0.99A 1rmtC-1r47A:
undetectable		 1rmtC-1r47A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens) 		4 / 6 ALA A 348
SER A 345
ILE A 319
ASP A 322
 None
 1.04A 1yc2A-1r47A:
undetectable		 1yc2A-1r47A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens) 		3 / 3 ALA A 156
THR A 194
PHE A 169
 None
 0.71A 2c6nB-1r47A:
0.0		 2c6nB-1r47A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens) 		4 / 8 SER A 235
ASP A 233
SER A 238
GLN A 280
 None
 1.11A 2cmlC-1r47A:
undetectable		 2cmlC-1r47A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens) 		4 / 6 TYR A  86
LEU A 300
ASN A 298
ASP A 234
 None
 1.24A 2w98A-1r47A:
0.8
2w98B-1r47A:
0.8		 2w98A-1r47A:
21.54
2w98B-1r47A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens) 		4 / 6 MET A  42
GLY A  80
MET A  76
TRP A  81
 None
 1.47A 3aqiA-1r47A:
2.8		 3aqiA-1r47A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens) 		4 / 7 PHE A 273
GLY A 271
ASP A 299
ARG A 301
 None
 1.20A 3aruA-1r47A:
4.5		 3aruA-1r47A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens) 		5 / 12 HIS A 125
VAL A 199
LEU A 166
LEU A  36
GLY A  43
 None
 1.15A 3kk6B-1r47A:
0.0		 3kk6B-1r47A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens) 		4 / 6 ILE A 407
VAL A 413
LEU A 415
LEU A 403
 None
 0.89A 3kp6A-1r47A:
undetectable
3kp6B-1r47A:
undetectable		 3kp6A-1r47A:
17.51
3kp6B-1r47A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens) 		4 / 8 LEU A 403
VAL A 351
LEU A 394
TYR A 397
 None
 1.09A 3v81A-1r47A:
undetectable		 3v81A-1r47A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens) 		4 / 8 VAL A 351
LEU A 415
LEU A 417
ILE A 367
 None
 0.91A 4lzrA-1r47A:
undetectable		 4lzrA-1r47A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens) 		4 / 7 ARG A 196
VAL A 199
HIS A 125
GLU A  87
 None
 1.25A 5ad9A-1r47A:
undetectable
5ad9B-1r47A:
undetectable		 5ad9A-1r47A:
19.79
5ad9B-1r47A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens) 		5 / 12 ILE A 289
LEU A 324
VAL A 254
LEU A 286
THR A 246
 None
 1.28A 5bykA-1r47A:
0.1		 5bykA-1r47A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens) 		4 / 6 ASP A 264
HIS A 225
ILE A 219
TYR A 184
 None
 1.20A 5ih0A-1r47A:
2.8		 5ih0A-1r47A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens) 		5 / 9 ALA A  97
ILE A  91
ILE A 133
ILE A 117
PHE A 113
 None
 0.97A 5nunA-1r47A:
0.0		 5nunA-1r47A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens) 		4 / 4 VAL A 413
LEU A 414
LEU A 387
ASP A 313
 None
 1.20A 5xv7A-1r47A:
0.0		 5xv7A-1r47A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens) 		5 / 12 ILE A 289
LEU A 324
VAL A 254
LEU A 286
THR A 246
 None
 1.19A 6b52A-1r47A:
undetectable		 6b52A-1r47A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		 1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens) 		5 / 11 ASP A 136
ASN A 139
ASP A 175
GLY A 183
ASP A 182
 None
NAG  A 639 (-1.9A)
NAG  A 639 ( 3.4A)
None
None
 1.47A 6mb5A-1r47A:
0.0		 6mb5A-1r47A:
12.96