SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r4a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1r4a ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Rattus
norvegicus) 		5 / 12 GLY A  24
GLU A 106
GLY A  70
VAL A 123
ARG A  99
 None
None
GNP  A1201 (-3.9A)
None
None
 1.23A 1n2xA-1r4aA:
4.2		 1n2xA-1r4aA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1r4a ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Rattus
norvegicus) 		5 / 12 THR A  48
GLY A  29
GLY A  27
GLY A  70
ASP A 129
 GNP  A1201 ( 3.6A)
GNP  A1201 (-3.1A)
GNP  A1201 (-3.7A)
GNP  A1201 (-3.9A)
GNP  A1201 (-3.0A)
 1.01A 2b25A-1r4aA:
2.9		 2b25A-1r4aA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1r4a ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
GOLGI AUTOANTIGEN,
GOLGIN SUBFAMILY A
MEMBER 4
(Rattus
norvegicus;
Homo
sapiens) 		4 / 6 ARG A  19
THR E2193
THR E2200
ASP E2206
 None
 1.24A 2okcB-1r4aA:
undetectable		 2okcB-1r4aA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 1r4a ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Rattus
norvegicus) 		5 / 11 TYR A  81
PHE A  51
VAL A  53
TRP A  66
VAL A  91
 None
 1.39A 2vcdA-1r4aA:
undetectable		 2vcdA-1r4aA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1r4a ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Rattus
norvegicus) 		5 / 8 GLY A  70
GLY A  69
GLY A  29
ILE A  22
VAL A  91
 GNP  A1201 (-3.9A)
GNP  A1201 (-3.6A)
GNP  A1201 (-3.1A)
None
None
 0.94A 3v1nA-1r4aA:
4.4		 3v1nA-1r4aA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1r4a ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Rattus
norvegicus) 		4 / 8 SER A 137
ILE A 155
ASN A 141
TRP A 153
 None
 1.06A 4d33A-1r4aA:
undetectable		 4d33A-1r4aA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 1r4a ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1
(Rattus
norvegicus) 		5 / 12 ALA A 109
MET A 110
LEU A 143
LYS A  30
GLY A  70
 None
None
None
GNP  A1201 (-2.9A)
GNP  A1201 (-3.9A)
 1.29A 4kykA-1r4aA:
0.2
4kykB-1r4aA:
0.4		 4kykA-1r4aA:
22.66
4kykB-1r4aA:
22.66