SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r4k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1r4k ARGONAUTE 1
(Drosophila
melanogaster) 		5 / 9 GLN A 367
ILE A 337
VAL A 356
VAL A 405
GLN A 404
 None
 1.39A 3fi0R-1r4kA:
undetectable		 3fi0R-1r4kA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 1r4k ARGONAUTE 1
(Drosophila
melanogaster) 		4 / 8 VAL A 305
PRO A 401
GLN A 404
ILE A 337
 None
 1.07A 4iilA-1r4kA:
undetectable		 4iilA-1r4kA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1r4k ARGONAUTE 1
(Drosophila
melanogaster) 		4 / 8 THR A 334
ILE A 342
LEU A 313
LEU A 416
 None
 1.00A 4r38B-1r4kA:
undetectable		 4r38B-1r4kA:
24.32