SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r4n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 GLU A 181
ALA A 275
LEU A 185
LEU A 342
MET A 332
 None
 1.36A 1a29A-1r4nA:
0.0		 1a29A-1r4nA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		5 / 12 THR B 182
ASP B 179
LEU B  63
LEU B  59
GLY B  58
 None
 1.47A 1d4fD-1r4nB:
4.6		 1d4fD-1r4nB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 VAL A 357
GLY A 358
ALA A 310
LEU A 311
 None
 0.81A 1e7bB-1r4nA:
undetectable		 1e7bB-1r4nA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 CYH A 483
ASP A 453
VAL A 479
GLY A 455
 None
 1.04A 1ekjC-1r4nA:
1.2
1ekjD-1r4nA:
2.6		 1ekjC-1r4nA:
19.02
1ekjD-1r4nA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 CYH A 483
ASP A 453
VAL A 479
GLY A 455
 None
 1.03A 1ekjC-1r4nA:
1.2
1ekjD-1r4nA:
2.6		 1ekjC-1r4nA:
19.02
1ekjD-1r4nA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 GLY A  53
LEU A  28
VAL A 505
PHE A  57
 None
 1.00A 1gsfA-1r4nA:
undetectable		 1gsfA-1r4nA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 GLY A  53
LEU A  28
VAL A 505
PHE A  57
 None
 1.00A 1gsfB-1r4nA:
undetectable		 1gsfB-1r4nA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 GLY A  53
LEU A  28
VAL A 505
PHE A  57
 None
 1.00A 1gsfC-1r4nA:
undetectable		 1gsfC-1r4nA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 GLY A  53
LEU A  28
VAL A 505
PHE A  57
 None
 1.00A 1gsfD-1r4nA:
undetectable		 1gsfD-1r4nA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 4 ILE A 368
LEU A 365
VAL A 361
ALA A 354
 None
 0.94A 1mz9A-1r4nA:
undetectable		 1mz9A-1r4nA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 ILE A 368
LEU A 365
VAL A 361
ALA A 354
 None
 0.87A 1mz9C-1r4nA:
undetectable		 1mz9C-1r4nA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 THR A 135
LEU A 139
VAL A 142
 None
 0.22A 1mz9E-1r4nA:
undetectable		 1mz9E-1r4nA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		3 / 3 VAL B 302
ALA B 301
HIS A 491
 None
 0.73A 1q23C-1r4nB:
undetectable		 1q23C-1r4nB:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		3 / 3 VAL B 302
ALA B 301
HIS A 491
 None
 0.70A 1q23H-1r4nB:
undetectable		 1q23H-1r4nB:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		3 / 3 VAL B 302
ALA B 301
HIS A 491
 None
 0.60A 1q23G-1r4nB:
undetectable		 1q23G-1r4nB:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		3 / 3 VAL B 302
ALA B 301
HIS A 491
 None
 0.67A 1q23J-1r4nB:
undetectable		 1q23J-1r4nB:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens;
Homo
sapiens) 		5 / 11 ILE A 493
THR A 492
LEU A 158
PHE B  23
HIS B  19
 None
 1.43A 1tw4A-1r4nA:
undetectable		 1tw4A-1r4nA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		6 / 12 ALA A 500
ALA A 501
GLN A 503
ILE A 164
PHE A 516
LEU B 330
 None
 1.40A 2aclG-1r4nA:
undetectable		 2aclG-1r4nA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		5 / 7 ALA A 500
GLY A 498
GLY A 499
ASN A  48
PHE B 324
 None
 1.24A 2c49B-1r4nA:
2.1		 2c49B-1r4nA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 PHE A 120
PHE A 119
HIS A  32
VAL A 126
 None
 1.26A 2lh6A-1r4nA:
0.0		 2lh6A-1r4nA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		4 / 8 ARG A 396
ASP B 328
GLY B 329
PHE A 516
 None
 0.86A 2tsrB-1r4nA:
undetectable		 2tsrB-1r4nA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 8 LEU A 113
LEU A 139
ILE A  60
VAL A 126
ILE A 148
 None
 1.26A 2uxpA-1r4nA:
2.2		 2uxpA-1r4nA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA303_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 4 GLN A  16
GLN A  25
GLY A  21
HIS A  23
 None
 1.47A 3huoA-1r4nA:
0.0		 3huoA-1r4nA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		4 / 5 ARG B 114
ARG B  95
ILE B  83
PHE B  94
 None
 1.10A 3ln1D-1r4nB:
0.0		 3ln1D-1r4nB:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		5 / 12 GLY B  60
GLY B 144
ALA B 104
ALA B 107
LEU B  64
 None
 1.19A 3mteA-1r4nB:
4.2		 3mteA-1r4nB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 ALA A  31
GLY A  53
VAL A  50
VAL A 505
ILE A 509
 None
 1.09A 3oxvB-1r4nA:
undetectable		 3oxvB-1r4nA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 ALA A  31
GLY A  53
VAL A  50
VAL A 505
ILE A 509
 None
 1.08A 3oxvD-1r4nA:
undetectable		 3oxvD-1r4nA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		5 / 12 ILE B 299
LEU B 322
GLY A 498
GLY A 499
ASN A  48
 None
 0.99A 3vasB-1r4nB:
5.0		 3vasB-1r4nB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 4 ASN A  72
SER A 523
LEU A 158
THR A  39
 None
 1.48A 4an2A-1r4nA:
undetectable		 4an2A-1r4nA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 GLN A 343
ASP A 331
GLU A 263
LEU A 342
 None
 1.33A 4ax8A-1r4nA:
5.9		 4ax8A-1r4nA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		4 / 7 ASP B 252
ASP B 146
ASN B  87
ASP B  81
 None
ATP  B   5 (-2.9A)
ATP  B   5 ( 4.4A)
ATP  B   5 (-3.7A)
 1.11A 4feuB-1r4nB:
undetectable		 4feuB-1r4nB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		4 / 7 ASP B 252
ASP B 146
ASN B  87
ASP B  81
 None
ATP  B   5 (-2.9A)
ATP  B   5 ( 4.4A)
ATP  B   5 (-3.7A)
 1.19A 4fevD-1r4nB:
undetectable		 4fevD-1r4nB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		4 / 7 ASP B 252
ASP B 146
ASN B  87
ASP B  81
 None
ATP  B   5 (-2.9A)
ATP  B   5 ( 4.4A)
ATP  B   5 (-3.7A)
 1.21A 4fevF-1r4nB:
undetectable		 4fevF-1r4nB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		4 / 8 ASP B 252
ASP B 146
ASN B  87
ASP B  81
 None
ATP  B   5 (-2.9A)
ATP  B   5 ( 4.4A)
ATP  B   5 (-3.7A)
 1.20A 4fewD-1r4nB:
undetectable		 4fewD-1r4nB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		4 / 7 ASP B 252
ASP B 146
ASN B  87
ASP B  81
 None
ATP  B   5 (-2.9A)
ATP  B   5 ( 4.4A)
ATP  B   5 (-3.7A)
 1.22A 4fexB-1r4nB:
undetectable		 4fexB-1r4nB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		5 / 12 ILE B 192
LEU B 145
LEU B 158
GLY B 156
TYR B 135
 None
ATP  B   5 (-4.5A)
None
None
None
 1.22A 4foxB-1r4nB:
0.0		 4foxB-1r4nB:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		4 / 8 ASP B 252
ASP B 146
ASN B  87
ASP B  81
 None
ATP  B   5 (-2.9A)
ATP  B   5 ( 4.4A)
ATP  B   5 (-3.7A)
 1.19A 4gkhB-1r4nB:
undetectable		 4gkhB-1r4nB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		4 / 6 ASP B 252
ASP B 146
ASN B  87
ASP B  81
 None
ATP  B   5 (-2.9A)
ATP  B   5 ( 4.4A)
ATP  B   5 (-3.7A)
 1.24A 4gkhJ-1r4nB:
undetectable		 4gkhJ-1r4nB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		4 / 8 ASP B 146
ASP B  84
ASP B  81
ASP B 250
 ATP  B   5 (-2.9A)
None
ATP  B   5 (-3.7A)
None
 0.91A 4gkhC-1r4nB:
undetectable
4gkhK-1r4nB:
undetectable		 4gkhC-1r4nB:
21.20
4gkhK-1r4nB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		4 / 8 ASP B 252
ASP B 146
ASN B  87
ASP B  81
 None
ATP  B   5 (-2.9A)
ATP  B   5 ( 4.4A)
ATP  B   5 (-3.7A)
 1.22A 4gkiA-1r4nB:
undetectable		 4gkiA-1r4nB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		4 / 8 ASP B 146
ASP B  84
ASP B  81
ASP B 250
 ATP  B   5 (-2.9A)
None
ATP  B   5 (-3.7A)
None
 0.87A 4gkiE-1r4nB:
undetectable
4gkiG-1r4nB:
undetectable		 4gkiE-1r4nB:
21.20
4gkiG-1r4nB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 ARG A 184
PRO A 188
ALA A 219
PHE A 196
GLU A 194
 None
 1.39A 4la0A-1r4nA:
2.1		 4la0A-1r4nA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 GLN A 503
THR A 129
LEU A  46
LEU A  49
 None
 1.09A 4lvcB-1r4nA:
2.2		 4lvcB-1r4nA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ASN A  37
ALA A  40
ASN A  73
LEU A  76
ASP A  61
 None
 1.20A 4qckA-1r4nA:
undetectable		 4qckA-1r4nA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ASN A  37
LEU A  93
ALA A  40
ASN A  73
LEU A  76
 None
 1.20A 4qckA-1r4nA:
undetectable		 4qckA-1r4nA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY B  60
ALA B  56
ILE B 299
ASN B 296
GLN A 527
 None
ATP  B   5 (-4.7A)
None
None
None
 1.27A 4rtpA-1r4nB:
4.0		 4rtpA-1r4nB:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 4 ASN A 517
LEU A 398
PHE A 532
TYR A 161
 None
 1.29A 4u14A-1r4nA:
undetectable		 4u14A-1r4nA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 185
ALA A 268
VAL A 272
ALA A 275
ILE A 247
 None
 1.10A 4x1kD-1r4nA:
2.4		 4x1kD-1r4nA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		5 / 12 GLY B  55
ASP B  79
ILE B 127
LEU B  63
LEU B 145
 ATP  B   5 ( 4.0A)
ATP  B   5 (-2.7A)
ATP  B   5 (-4.0A)
None
ATP  B   5 (-4.5A)
 1.04A 5bw4A-1r4nB:
4.5		 5bw4A-1r4nB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		5 / 11 ILE B 192
LEU B 145
LEU B 158
GLY B 156
TYR B 135
 None
ATP  B   5 (-4.5A)
None
None
None
 1.16A 5fctA-1r4nB:
undetectable		 5fctA-1r4nB:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		4 / 8 ILE A 493
THR B 332
LEU B 322
LEU B 318
 None
 0.79A 5hs1A-1r4nA:
undetectable		 5hs1A-1r4nA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		4 / 6 PHE B 213
PRO B 214
ARG B 223
ILE B 218
 None
 1.30A 5ih0A-1r4nB:
undetectable		 5ih0A-1r4nB:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		3 / 3 ARG B  95
ILE B  83
PHE B  94
 None
 0.76A 5kirA-1r4nB:
undetectable		 5kirA-1r4nB:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 8 VAL A 127
ILE A  45
ALA A 502
PHE A 123
VAL A 125
 None
 1.07A 5l94A-1r4nA:
undetectable		 5l94A-1r4nA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		4 / 7 THR B  31
ARG A 484
LEU B  24
SER B  70
 None
 1.11A 5uxcA-1r4nB:
undetectable		 5uxcA-1r4nB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 ASP A 186
LEU A 185
LEU A 342
ILE A 329
THR A 279
 None
 1.08A 5z6mA-1r4nA:
undetectable		 5z6mA-1r4nA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		4 / 8 GLY B 100
ILE B  99
ASP B 252
PRO B 254
 None
 0.89A 6ag0A-1r4nB:
undetectable		 6ag0A-1r4nB:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		4 / 8 GLY B 100
ILE B  99
ASP B 252
PRO B 254
 None
 0.88A 6ag0C-1r4nB:
undetectable		 6ag0C-1r4nB:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		5 / 10 GLY B 144
GLY B  55
ASP B 146
ASN B 296
ILE B 299
 None
ATP  B   5 ( 4.0A)
ATP  B   5 (-2.9A)
None
None
 1.14A 6exiA-1r4nB:
4.3		 6exiA-1r4nB:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		5 / 10 GLY B 144
GLY B  55
ASP B 146
ASN B 296
ILE B 299
 None
ATP  B   5 ( 4.0A)
ATP  B   5 (-2.9A)
None
None
 1.17A 6exiB-1r4nB:
4.7		 6exiB-1r4nB:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		5 / 12 GLY B 144
GLY B  55
ASP B 146
ASN B 296
ILE B 299
 None
ATP  B   5 ( 4.0A)
ATP  B   5 (-2.9A)
None
None
 1.14A 6exiC-1r4nB:
4.5
6exiD-1r4nB:
4.6		 6exiC-1r4nB:
14.43
6exiD-1r4nB:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		5 / 12 GLY B 144
GLY B  55
ASP B 146
ASN B 296
ILE B 299
 None
ATP  B   5 ( 4.0A)
ATP  B   5 (-2.9A)
None
None
 1.12A 6exiC-1r4nB:
4.6
6exiD-1r4nB:
4.4		 6exiC-1r4nB:
14.43
6exiD-1r4nB:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		4 / 7 ASP B  84
ARG B  90
LYS B 286
GLN B 282
 None
ATP  B   5 (-3.2A)
None
None
 1.31A 6g31G-1r4nB:
undetectable		 6g31G-1r4nB:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens;
Homo
sapiens) 		4 / 7 HIS B  19
THR A 155
TYR A 156
LEU A 425
 None
 1.21A 6nmfA-1r4nB:
undetectable
6nmfC-1r4nB:
undetectable
6nmfP-1r4nB:
undetectable		 6nmfA-1r4nB:
20.70
6nmfC-1r4nB:
18.99
6nmfP-1r4nB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		5 / 11 GLY B  57
LEU B  64
ALA B 108
PHE B  94
ALA B 104
 ATP  B   5 (-3.8A)
None
None
None
None
 1.24A 6qgbA-1r4nB:
undetectable		 6qgbA-1r4nB:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		5 / 11 GLY B  57
LEU B  64
ALA B 108
PHE B  94
ALA B 104
 ATP  B   5 (-3.8A)
None
None
None
None
 1.24A 6qgbE-1r4nB:
undetectable		 6qgbE-1r4nB:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 1r4n UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens) 		5 / 12 ILE B 192
LEU B 145
LEU B 158
GLY B 156
TYR B 135
 None
ATP  B   5 (-4.5A)
None
None
None
 1.17A 6r2eA-1r4nB:
0.0		 6r2eA-1r4nB:
20.23