SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r4p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
4 / 6 PHE A  92
LEU A 159
VAL A 162
ASP A 111
FMT  A3015 ( 4.9A)
None
FMT  A3015 (-4.4A)
None
1.16A 1dz4A-1r4pA:
0.0
1dz4A-1r4pA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
5 / 12 THR A 110
ILE A   5
THR A 165
LEU A 117
LEU A 142
FMT  A3010 (-2.7A)
None
None
None
None
1.07A 1eiiA-1r4pA:
0.0
1eiiA-1r4pA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
5 / 9 PHE A  92
TYR A 114
ALA A 166
GLU A 167
ARG A 170
FMT  A3015 ( 4.9A)
FMT  A3015 ( 4.1A)
FMT  A3015 ( 4.9A)
None
None
0.41A 1mrgA-1r4pA:
23.2
1mrgA-1r4pA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
4 / 5 SER A 134
SER A 138
VAL A 164
PHE A 161
FMT  A3013 (-2.6A)
None
None
None
0.95A 1oipA-1r4pA:
undetectable
1oipA-1r4pA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
4 / 8 SER A  39
LEU A  28
ILE A 228
ILE A  31
None
0.96A 1sbrA-1r4pA:
undetectable
1sbrA-1r4pA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
4 / 4 LEU A 135
SER A 138
TYR A 139
LEU A  57
None
0.93A 1xz1A-1r4pA:
0.0
1xz1A-1r4pA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
4 / 4 LEU A 135
SER A 138
TYR A 139
LEU A  57
None
0.93A 1xz3A-1r4pA:
0.0
1xz3A-1r4pA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
5 / 12 ASP A  94
MET A 150
PHE A 145
PHE A  92
GLY A  80
None
None
None
FMT  A3015 ( 4.9A)
None
1.44A 2fqyA-1r4pA:
undetectable
2fqyA-1r4pA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
3 / 3 ASN A 201
ILE A 174
MET A 191
None
0.60A 2h42C-1r4pA:
undetectable
2h42C-1r4pA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
5 / 10 TYR A  13
ILE A   5
PHE A 178
LEU A  57
LEU A 135
None
1.13A 2w98A-1r4pA:
undetectable
2w98A-1r4pA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
4 / 8 TYR A  13
ILE A   5
LEU A  57
LEU A 135
None
0.86A 2w98B-1r4pA:
undetectable
2w98B-1r4pA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
4 / 8 LEU A  57
ILE A 130
PHE A 178
PHE A 161
None
0.73A 2weyB-1r4pA:
undetectable
2weyB-1r4pA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
3 / 3 SER A 183
ARG A 179
GLN A 180
None
FMT  A3001 ( 3.9A)
None
0.88A 2xnrA-1r4pA:
undetectable
2xnrA-1r4pA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
4 / 5 TYR A  13
ILE A   5
LEU A  57
LEU A 135
None
1.07A 2zb7A-1r4pA:
undetectable
2zb7A-1r4pA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
4 / 7 LEU A 123
SER A 126
THR A 190
VAL A 188
None
None
None
FMT  A3013 ( 4.7A)
0.88A 3d2tA-1r4pA:
undetectable
3d2tA-1r4pA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
4 / 7 ASP A 195
GLN A 129
GLN A 180
GLU A 177
None
FMT  A3013 (-4.9A)
None
None
0.84A 3l2vA-1r4pA:
undetectable
3l2vA-1r4pA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
4 / 6 LEU A 135
SER A 138
TYR A 139
LEU A  57
None
0.95A 3ravA-1r4pA:
undetectable
3ravA-1r4pA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
5 / 10 TYR A  77
TYR A 114
ALA A 166
GLU A 167
ARG A 170
FMT  A3015 (-4.7A)
FMT  A3015 ( 4.1A)
FMT  A3015 ( 4.9A)
None
None
0.77A 3u6tA-1r4pA:
23.2
3u6tA-1r4pA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
5 / 11 SER A 134
LEU A 135
SER A 138
VAL A 164
PHE A 161
FMT  A3013 (-2.6A)
None
None
None
None
1.09A 3w67A-1r4pA:
undetectable
3w67A-1r4pA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
5 / 12 SER A 134
LEU A 135
SER A 138
VAL A 164
PHE A 161
FMT  A3013 (-2.6A)
None
None
None
None
1.18A 3w68A-1r4pA:
undetectable
3w68A-1r4pA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
5 / 8 ILE A  54
ASP A  53
VAL A 158
SER A 112
GLY A  80
None
None
None
FMT  A3015 (-4.0A)
None
1.36A 4ac9C-1r4pA:
undetectable
4ac9C-1r4pA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_B_MOAB1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
5 / 10 SER A  16
SER A  15
ASN A  18
ARG A  21
GLN A  11
EDO  A2004 (-4.3A)
NA  A4003 (-2.5A)
None
None
None
1.43A 4af0B-1r4pA:
undetectable
4af0B-1r4pA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
4 / 8 PHE A  95
ASP A 111
VAL A 158
GLY A  80
None
0.93A 4m48A-1r4pA:
undetectable
4m48A-1r4pA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
4 / 5 VAL A  82
ILE A  70
LEU A  69
ARG A  68
None
0.82A 4mghA-1r4pA:
undetectable
4mghA-1r4pA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
3 / 3 GLU A 167
ALA A 168
PHE A 171
None
0.62A 4v1fA-1r4pA:
undetectable
4v1fA-1r4pA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
3 / 3 GLU A 167
ALA A 168
PHE A 171
None
0.58A 4v1fC-1r4pA:
undetectable
4v1fC-1r4pA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
5 / 9 PHE A  92
TYR A 114
ALA A 166
GLU A 167
ARG A 170
FMT  A3015 ( 4.9A)
FMT  A3015 ( 4.1A)
FMT  A3015 ( 4.9A)
None
None
0.42A 4yp2B-1r4pA:
22.3
4yp2B-1r4pA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
5 / 9 TYR A  77
TYR A 114
ALA A 166
GLU A 167
ARG A 170
FMT  A3015 (-4.7A)
FMT  A3015 ( 4.1A)
FMT  A3015 ( 4.9A)
None
None
0.52A 4yp2B-1r4pA:
22.3
4yp2B-1r4pA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
5 / 9 PHE A  92
TYR A 114
ALA A 166
GLU A 167
ARG A 170
FMT  A3015 ( 4.9A)
FMT  A3015 ( 4.1A)
FMT  A3015 ( 4.9A)
None
None
0.40A 5cf9B-1r4pA:
23.3
5cf9B-1r4pA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
5 / 9 TYR A  77
TYR A 114
ALA A 166
GLU A 167
ARG A 170
FMT  A3015 (-4.7A)
FMT  A3015 ( 4.1A)
FMT  A3015 ( 4.9A)
None
None
0.52A 5cf9B-1r4pA:
23.3
5cf9B-1r4pA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
3 / 3 VAL A 120
LEU A  67
MET A 143
FMT  A3010 (-4.5A)
None
None
0.90A 5ikrA-1r4pA:
undetectable
5ikrA-1r4pA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
5 / 12 GLU A 277
LEU A 209
GLY A 203
ASN A 201
LEU A 198
None
1.22A 5kbwA-1r4pA:
undetectable
5kbwA-1r4pA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
5 / 12 GLU A 277
LEU A 209
GLY A 203
ASN A 201
LEU A 198
None
1.34A 5kc4E-1r4pA:
undetectable
5kc4E-1r4pA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
3 / 3 GLY A 102
THR A 104
ASN A  87
None
0.55A 5odiG-1r4pA:
undetectable
5odiG-1r4pA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
3 / 3 MET A 128
GLU A 167
ARG A 125
None
1.00A 5tjyA-1r4pA:
undetectable
5tjyA-1r4pA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
3 / 3 MET A 128
GLU A 167
ARG A 125
None
1.09A 5tjzA-1r4pA:
undetectable
5tjzA-1r4pA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
5 / 6 TYR A  77
VAL A  78
TYR A 114
GLU A 167
ARG A 170
FMT  A3015 (-4.7A)
FMT  A3015 (-3.7A)
FMT  A3015 ( 4.1A)
None
None
0.69A 5z3jA-1r4pA:
24.3
5z3jA-1r4pA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
5 / 10 TYR A  90
MET A 108
ALA A  79
PHE A  92
LEU A 142
None
None
None
FMT  A3015 ( 4.9A)
None
1.35A 6ay4A-1r4pA:
undetectable
6ay4A-1r4pA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli)
5 / 12 TRP A 202
LEU A 239
VAL A  40
SER A  25
THR A  26
None
None
None
None
NA  A4001 ( 4.7A)
1.43A 6drxA-1r4pA:
undetectable
6drxA-1r4pA:
19.22