SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r4v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 1r4v HYPOTHETICAL PROTEIN
AQ_328
(Aquifex
aeolicus) 		5 / 12 VAL A 106
GLY A 105
MET A 104
LEU A  32
VAL A  56
 None
 0.98A 1a27A-1r4vA:
undetectable		 1a27A-1r4vA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1r4v HYPOTHETICAL PROTEIN
AQ_328
(Aquifex
aeolicus) 		3 / 3 ILE A  49
LEU A  52
VAL A  56
 None
 0.22A 1mz9B-1r4vA:
undetectable		 1mz9B-1r4vA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 1r4v HYPOTHETICAL PROTEIN
AQ_328
(Aquifex
aeolicus) 		4 / 7 ILE A  79
LEU A  84
PHE A  60
MET A 135
 None
 0.98A 4hajA-1r4vA:
undetectable		 4hajA-1r4vA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 1r4v HYPOTHETICAL PROTEIN
AQ_328
(Aquifex
aeolicus) 		4 / 8 ILE A  49
LEU A  53
ILE A 146
GLY A 136
 None
 0.89A 4hb6A-1r4vA:
undetectable		 4hb6A-1r4vA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1r4v HYPOTHETICAL PROTEIN
AQ_328
(Aquifex
aeolicus) 		5 / 12 LEU A 138
GLY A  61
PHE A  64
LEU A 127
ILE A  86
 None
 1.13A 4hytA-1r4vA:
undetectable		 4hytA-1r4vA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1r4v HYPOTHETICAL PROTEIN
AQ_328
(Aquifex
aeolicus) 		5 / 12 LEU A 138
GLY A  61
PHE A  64
LEU A 127
ILE A  86
 None
 1.14A 4hytC-1r4vA:
undetectable		 4hytC-1r4vA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1r4v HYPOTHETICAL PROTEIN
AQ_328
(Aquifex
aeolicus) 		4 / 4 LEU A  40
ARG A  37
ILE A  42
PHE A  36
 None
CAC  A 203 (-2.8A)
None
None
 1.15A 5kirB-1r4vA:
undetectable		 5kirB-1r4vA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1r4v HYPOTHETICAL PROTEIN
AQ_328
(Aquifex
aeolicus) 		3 / 3 ASP A 103
PHE A  97
ARG A 132
 None
 1.15A 5yw0A-1r4vA:
undetectable		 5yw0A-1r4vA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWV_A_BEZA202_0
(ARA H 8 ALLERGEN)		 1r4v HYPOTHETICAL PROTEIN
AQ_328
(Aquifex
aeolicus) 		4 / 4 PHE A 171
ASP A 168
LEU A  63
LYS A  62
 None
 1.48A 6awvA-1r4vA:
0.0		 6awvA-1r4vA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 1r4v HYPOTHETICAL PROTEIN
AQ_328
(Aquifex
aeolicus) 		5 / 12 GLY A  66
ALA A  67
GLY A  61
LEU A  81
ILE A  79
 None
 1.02A 6dh6B-1r4vA:
undetectable		 6dh6B-1r4vA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1r4v HYPOTHETICAL PROTEIN
AQ_328
(Aquifex
aeolicus) 		5 / 10 ILE A  42
VAL A  56
ALA A  59
LEU A  52
LEU A 139
 None
 0.99A 6f6nA-1r4vA:
undetectable
6f6nB-1r4vA:
undetectable		 6f6nA-1r4vA:
19.28
6f6nB-1r4vA:
20.51