SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r4w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 1r4w GLUTATHIONE
S-TRANSFERASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		3 / 3 VAL A 117
TRP A  20
TRP A 122
 None
 1.30A 1c4dA-1r4wA:
undetectable
1c4dB-1r4wA:
undetectable		 1c4dA-1r4wA:
4.65
1c4dB-1r4wA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 1r4w GLUTATHIONE
S-TRANSFERASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		4 / 7 GLU A   9
ARG A  40
THR A 171
ALA A 174
 None
 1.05A 3mbgA-1r4wA:
0.1
3mbgB-1r4wA:
0.0		 3mbgA-1r4wA:
20.09
3mbgB-1r4wA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1r4w GLUTATHIONE
S-TRANSFERASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		4 / 5 VAL A 106
LEU A 103
ILE A 138
ALA A 142
 None
 0.90A 3n8yB-1r4wA:
undetectable		 3n8yB-1r4wA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 1r4w GLUTATHIONE
S-TRANSFERASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		5 / 11 LEU A 103
ASP A  13
LEU A 183
THR A 172
GLY A  46
 None
 1.41A 3sfuC-1r4wA:
undetectable		 3sfuC-1r4wA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 1r4w GLUTATHIONE
S-TRANSFERASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		5 / 12 ILE A 125
ASP A  13
LEU A  44
ILE A  70
PHE A  87
 None
None
GSH  A 301 ( 4.9A)
None
None
 1.29A 5tiwB-1r4wA:
1.8		 5tiwB-1r4wA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1r4w GLUTATHIONE
S-TRANSFERASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		4 / 7 ILE A 132
ARG A 101
THR A 104
LEU A 103
 None
 0.92A 5zcpA-1r4wA:
undetectable
5zcpJ-1r4wA:
undetectable		 5zcpA-1r4wA:
17.32
5zcpJ-1r4wA:
13.51