SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r4x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1r4x COATOMER GAMMA
SUBUNIT
(Homo
sapiens) 		3 / 3 ARG A 859
GLU A 784
SER A 816
 None
 0.85A 2xctD-1r4xA:
2.1		 2xctD-1r4xA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_2
(BETA-LACTAMASE)		 1r4x COATOMER GAMMA
SUBUNIT
(Homo
sapiens) 		4 / 5 CYH A 726
PRO A 683
THR A 723
THR A 678
 None
 1.50A 3q07B-1r4xA:
undetectable		 3q07B-1r4xA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 1r4x COATOMER GAMMA
SUBUNIT
(Homo
sapiens) 		3 / 3 VAL A 679
GLN A 662
CYH A 665
 None
 0.77A 5icxC-1r4xA:
0.0
5icxF-1r4xA:
undetectable		 5icxC-1r4xA:
22.30
5icxF-1r4xA:
4.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 1r4x COATOMER GAMMA
SUBUNIT
(Homo
sapiens) 		5 / 12 GLY A 832
LEU A 808
VAL A 842
LEU A 841
ALA A 775
 None
 0.96A 5kpcA-1r4xA:
undetectable		 5kpcA-1r4xA:
22.33