SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r4y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 1r4y RIBONUCLEASE
ALPHA-SARCIN
(Aspergillus
giganteus) 		3 / 3 LEU A 133
PHE A  57
ARG A  52
 None
 0.90A 1xdkB-1r4yA:
undetectable		 1xdkB-1r4yA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_B_ECNB1406_1
(CYTOCHROME P450 130)		 1r4y RIBONUCLEASE
ALPHA-SARCIN
(Aspergillus
giganteus) 		5 / 11 ASP A  77
PRO A  66
PRO A  65
GLY A  46
TYR A  79
 None
 1.50A 2uvnB-1r4yA:
undetectable		 2uvnB-1r4yA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1r4y RIBONUCLEASE
ALPHA-SARCIN
(Aspergillus
giganteus) 		5 / 9 LEU A 133
SER A 135
ALA A 106
THR A  85
ALA A  16
 None
 1.26A 3mdtA-1r4yA:
undetectable		 3mdtA-1r4yA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1r4y RIBONUCLEASE
ALPHA-SARCIN
(Aspergillus
giganteus) 		5 / 12 ASP A  91
ILE A 109
GLY A 119
SER A  18
PHE A 117
 None
 1.26A 4obwC-1r4yA:
undetectable		 4obwC-1r4yA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1r4y RIBONUCLEASE
ALPHA-SARCIN
(Aspergillus
giganteus) 		5 / 12 GLY A  44
ARG A 107
ILE A 109
PHE A  57
GLY A  41
 None
 0.89A 5koxA-1r4yA:
undetectable		 5koxA-1r4yA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 1r4y RIBONUCLEASE
ALPHA-SARCIN
(Aspergillus
giganteus) 		4 / 5 ILE A  55
PHE A  57
ASN A  73
TYR A 110
 None
 1.10A 6a93B-1r4yA:
undetectable		 6a93B-1r4yA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1r4y RIBONUCLEASE
ALPHA-SARCIN
(Aspergillus
giganteus) 		4 / 5 TYR A  34
VAL A 116
PHE A  86
GLY A 104
 None
 1.11A 6hd4A-1r4yA:
undetectable		 6hd4A-1r4yA:
22.02