SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r53'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1r53 CHORISMATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 SER A 307
THR A 220
GLU A 256
GLY A 258
 None
 0.92A 1icrA-1r53A:
undetectable
1icrB-1r53A:
undetectable		 1icrA-1r53A:
21.73
1icrB-1r53A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1r53 CHORISMATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 6 SER A 307
THR A 220
GLU A 256
GLY A 258
 None
 0.88A 1icuA-1r53A:
undetectable
1icuB-1r53A:
undetectable		 1icuA-1r53A:
21.73
1icuB-1r53A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1r53 CHORISMATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 256
GLY A 258
SER A 307
THR A 220
 None
 0.88A 1icuA-1r53A:
undetectable
1icuB-1r53A:
undetectable		 1icuA-1r53A:
21.73
1icuB-1r53A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1r53 CHORISMATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 6 SER A 307
THR A 220
GLU A 256
GLY A 258
 None
 0.94A 1icuC-1r53A:
undetectable
1icuD-1r53A:
1.6		 1icuC-1r53A:
21.73
1icuD-1r53A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1r53 CHORISMATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 SER A 307
THR A 220
GLU A 256
GLY A 258
 None
 0.91A 1icvC-1r53A:
1.6
1icvD-1r53A:
undetectable		 1icvC-1r53A:
21.73
1icvD-1r53A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1r53 CHORISMATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 256
GLY A 258
SER A 307
THR A 220
 None
 0.89A 1icvC-1r53A:
1.7
1icvD-1r53A:
undetectable		 1icvC-1r53A:
21.73
1icvD-1r53A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1r53 CHORISMATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 6 SER A 307
THR A 220
GLU A 256
GLY A 258
 None
 0.86A 1kqbA-1r53A:
1.4
1kqbB-1r53A:
1.5		 1kqbA-1r53A:
18.85
1kqbB-1r53A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1r53 CHORISMATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 256
GLY A 258
SER A 307
THR A 220
 None
 0.86A 1kqbA-1r53A:
1.4
1kqbB-1r53A:
1.5		 1kqbA-1r53A:
18.85
1kqbB-1r53A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1r53 CHORISMATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 256
GLY A 258
SER A 307
THR A 220
 None
 0.88A 1kqbC-1r53A:
undetectable
1kqbD-1r53A:
undetectable		 1kqbC-1r53A:
18.85
1kqbD-1r53A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1r53 CHORISMATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 257
GLY A 258
ASN A 303
ASN A 289
 None
 0.99A 1oniG-1r53A:
undetectable
1oniI-1r53A:
undetectable		 1oniG-1r53A:
19.28
1oniI-1r53A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1r53 CHORISMATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 356
ARG A  46
LEU A  43
GLY A  22
 None
 0.93A 2po5B-1r53A:
undetectable		 2po5B-1r53A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 1r53 CHORISMATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 4 ARG A 224
ASP A 166
GLY A 260
THR A 220
 None
 1.42A 3k4vB-1r53A:
undetectable		 3k4vB-1r53A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 1r53 CHORISMATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  43
CYH A  23
THR A  12
THR A  11
LEU A 356
 None
 1.23A 3sp9A-1r53A:
0.0		 3sp9A-1r53A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 1r53 CHORISMATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 9 ASN A 289
GLY A 292
GLY A 293
SER A 259
GLY A 258
 None
 1.10A 3ztvA-1r53A:
undetectable		 3ztvA-1r53A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1r53 CHORISMATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 9 SER A 135
ALA A 137
GLU A 140
LEU A  43
ILE A 349
 None
 1.28A 4xtaA-1r53A:
undetectable		 4xtaA-1r53A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1r53 CHORISMATE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  25
ASP A  26
ALA A 139
GLN A 365
PRO A  29
 None
 1.18A 5syfB-1r53A:
undetectable		 5syfB-1r53A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1r53 CHORISMATE SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 289
VAL A 266
HIS A 271
 None
 0.74A 6a5yD-1r53A:
0.0		 6a5yD-1r53A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1r53 CHORISMATE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 179
THR A 180
ARG A  45
GLU A 140
 None
 0.88A 6c06C-1r53A:
undetectable		 6c06C-1r53A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1r53 CHORISMATE SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 226
GLY A 293
PHE A 255
 None
 0.58A 6exiC-1r53A:
undetectable		 6exiC-1r53A:
13.09