SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r5a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1r5a GLUTATHIONE
TRANSFERASE
(Anopheles
cracens) 		4 / 8 ALA A 160
LEU A 103
LEU A  99
LEU A  71
 None
 0.80A 1e7cA-1r5aA:
3.5		 1e7cA-1r5aA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 1r5a GLUTATHIONE
TRANSFERASE
(Anopheles
cracens) 		5 / 12 LEU A 143
THR A 164
VAL A 165
ALA A 157
ALA A 160
 None
 1.22A 1n5xA-1r5aA:
undetectable		 1n5xA-1r5aA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 1r5a GLUTATHIONE
TRANSFERASE
(Anopheles
cracens) 		5 / 12 LEU A 143
THR A 164
VAL A 165
ALA A 157
ALA A 160
 None
 1.21A 1n5xB-1r5aA:
undetectable		 1n5xB-1r5aA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1r5a GLUTATHIONE
TRANSFERASE
(Anopheles
cracens) 		5 / 8 ALA A  21
LEU A  28
LEU A  30
ILE A 200
ILE A  54
 None
None
None
None
GTS  A1004 (-4.0A)
 1.24A 2uxpA-1r5aA:
undetectable		 2uxpA-1r5aA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1r5a GLUTATHIONE
TRANSFERASE
(Anopheles
cracens) 		3 / 3 LEU A 143
TRP A 138
TYR A 178
 None
 0.80A 3aicA-1r5aA:
undetectable		 3aicA-1r5aA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1r5a GLUTATHIONE
TRANSFERASE
(Anopheles
cracens) 		3 / 3 LEU A 143
TRP A 138
TYR A 178
 None
 0.78A 3aicB-1r5aA:
undetectable		 3aicB-1r5aA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1r5a GLUTATHIONE
TRANSFERASE
(Anopheles
cracens) 		3 / 3 LEU A 143
TRP A 138
TYR A 178
 None
 0.76A 3aicE-1r5aA:
undetectable		 3aicE-1r5aA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1r5a GLUTATHIONE
TRANSFERASE
(Anopheles
cracens) 		3 / 3 LEU A 143
TRP A 138
TYR A 178
 None
 0.79A 3aicF-1r5aA:
undetectable		 3aicF-1r5aA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1r5a GLUTATHIONE
TRANSFERASE
(Anopheles
cracens) 		3 / 3 LEU A 143
TRP A 138
TYR A 178
 None
 0.77A 3aicG-1r5aA:
undetectable		 3aicG-1r5aA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1r5a GLUTATHIONE
TRANSFERASE
(Anopheles
cracens) 		3 / 3 LEU A 143
TRP A 138
TYR A 178
 None
 0.74A 3aicH-1r5aA:
undetectable		 3aicH-1r5aA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1r5a GLUTATHIONE
TRANSFERASE
(Anopheles
cracens) 		4 / 6 LEU A 175
TYR A 178
VAL A 181
LEU A 132
 None
 0.88A 3cs9D-1r5aA:
undetectable		 3cs9D-1r5aA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1r5a GLUTATHIONE
TRANSFERASE
(Anopheles
cracens) 		5 / 9 THR A 207
ALA A 209
LEU A 208
GLN A 167
ALA A 170
 None
 1.46A 3kp6B-1r5aA:
0.0		 3kp6B-1r5aA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 1r5a GLUTATHIONE
TRANSFERASE
(Anopheles
cracens) 		3 / 3 PRO A  55
THR A  56
LEU A  33
 GTS  A1004 (-4.2A)
None
None
 0.68A 3ttrA-1r5aA:
undetectable		 3ttrA-1r5aA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 1r5a GLUTATHIONE
TRANSFERASE
(Anopheles
cracens) 		5 / 9 ALA A 160
LEU A 103
LEU A  99
LEU A  71
GLU A  66
 None
None
None
None
GTS  A1004 (-2.9A)
 1.18A 5dqfA-1r5aA:
3.1		 5dqfA-1r5aA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 1r5a GLUTATHIONE
TRANSFERASE
(Anopheles
cracens) 		3 / 3 ASP A  96
SER A  72
TYR A  85
 None
 0.64A 5glmA-1r5aA:
undetectable		 5glmA-1r5aA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 1r5a GLUTATHIONE
TRANSFERASE
(Anopheles
cracens) 		5 / 10 TYR A  73
TYR A  78
ILE A  24
ILE A 156
ILE A 159
 None
 1.09A 5murE-1r5aA:
3.0		 5murE-1r5aA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1r5a GLUTATHIONE
TRANSFERASE
(Anopheles
cracens) 		3 / 3 TYR A 113
ALA A 135
LEU A 136
 None
 0.53A 6ag0C-1r5aA:
undetectable		 6ag0C-1r5aA:
17.76