SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r5j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E
(Streptococcus
pyogenes) 		4 / 8 SER A 152
ALA A 169
PHE A 270
ILE A 185
 None
 1.11A 1gm7A-1r5jA:
undetectable
1gm7B-1r5jA:
undetectable		 1gm7A-1r5jA:
22.49
1gm7B-1r5jA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E
(Streptococcus
pyogenes) 		4 / 8 ALA A  34
GLY A  26
ALA A  35
ILE A  48
 None
 0.67A 1gtnI-1r5jA:
undetectable
1gtnJ-1r5jA:
undetectable		 1gtnI-1r5jA:
14.20
1gtnJ-1r5jA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E
(Streptococcus
pyogenes) 		3 / 4 LYS A  82
ALA A  86
MET A 117
 None
 0.93A 1hk3A-1r5jA:
undetectable		 1hk3A-1r5jA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E
(Streptococcus
pyogenes) 		4 / 6 LEU A 182
ALA A 186
SER A 152
THR A 189
 None
 1.19A 1tyrA-1r5jA:
undetectable		 1tyrA-1r5jA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E
(Streptococcus
pyogenes) 		3 / 3 VAL A  88
GLU A  85
GLU A  89
 None
 0.70A 2nv4A-1r5jA:
undetectable		 2nv4A-1r5jA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E
(Streptococcus
pyogenes) 		4 / 6 PRO A 294
ILE A 173
ASN A 277
LEU A 273
 None
 1.29A 2wekB-1r5jA:
3.3		 2wekB-1r5jA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E
(Streptococcus
pyogenes) 		5 / 12 LEU A 182
ALA A 186
ALA A 190
PRO A 200
THR A 267
 None
 1.24A 3cwkA-1r5jA:
undetectable		 3cwkA-1r5jA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E
(Streptococcus
pyogenes) 		5 / 12 VAL A  32
ALA A  35
ALA A 127
THR A  60
ILE A  71
 None
 1.27A 3dl9B-1r5jA:
undetectable		 3dl9B-1r5jA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E
(Streptococcus
pyogenes) 		3 / 3 ASN A  75
MET A 113
PHE A  80
 None
 1.09A 3g4lD-1r5jA:
undetectable		 3g4lD-1r5jA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E
(Streptococcus
pyogenes) 		4 / 8 VAL A  22
GLY A 122
ILE A 142
GLY A 111
 None
 0.80A 3n9jB-1r5jA:
undetectable		 3n9jB-1r5jA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E
(Streptococcus
pyogenes) 		3 / 3 ARG A  91
LYS A  92
LYS A  94
 None
 1.46A 4k50A-1r5jA:
0.0		 4k50A-1r5jA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E
(Streptococcus
pyogenes) 		3 / 3 ARG A  91
LYS A  92
LYS A  94
 None
 1.39A 4k50E-1r5jA:
0.0		 4k50E-1r5jA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E
(Streptococcus
pyogenes) 		3 / 3 ARG A  91
LYS A  92
LYS A  94
 None
 1.42A 4k50I-1r5jA:
0.0		 4k50I-1r5jA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E
(Streptococcus
pyogenes) 		5 / 12 GLY A 298
LEU A 182
ALA A 228
THR A 225
ALA A 186
 None
 1.14A 4uckB-1r5jA:
undetectable		 4uckB-1r5jA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E
(Streptococcus
pyogenes) 		4 / 6 ASN A 266
ASP A 197
THR A 189
VAL A 167
 None
 1.14A 4yoaA-1r5jA:
undetectable		 4yoaA-1r5jA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E
(Streptococcus
pyogenes) 		4 / 6 PHE A  40
TYR A  69
ARG A  56
THR A  60
 None
 1.00A 5b1aN-1r5jA:
0.0
5b1aW-1r5jA:
0.0		 5b1aN-1r5jA:
22.69
5b1aW-1r5jA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E
(Streptococcus
pyogenes) 		5 / 8 VAL A 269
ILE A 202
ALA A 190
VAL A 154
PHE A 168
 None
 1.34A 5l94A-1r5jA:
undetectable		 5l94A-1r5jA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E
(Streptococcus
pyogenes) 		3 / 3 TYR A  69
ARG A  56
THR A  60
 None
 1.03A 5z84J-1r5jA:
0.0		 5z84J-1r5jA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E
(Streptococcus
pyogenes) 		5 / 12 GLY A  50
THR A  70
TYR A  69
ARG A  56
LEU A  59
 None
 1.38A 6bp4A-1r5jA:
undetectable		 6bp4A-1r5jA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E
(Streptococcus
pyogenes) 		3 / 3 VAL A  55
GLU A  54
ILE A  71
 None
 0.50A 6f7lB-1r5jA:
4.4		 6f7lB-1r5jA:
21.35