SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r5l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		12 / 12 TYR A 100
ILE A 119
TRP A 122
VAL A 132
LEU A 137
ILE A 154
ILE A 171
ILE A 179
LEU A 183
VAL A 191
ILE A 194
ILE A 210
 None
None
None
VIV  A 301 ( 4.7A)
VIV  A 301 ( 4.8A)
None
None
VIV  A 301 ( 4.0A)
None
VIV  A 301 (-4.7A)
VIV  A 301 ( 4.5A)
None
 0.23A 1oipA-1r5lA:
43.4		 1oipA-1r5lA:
93.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		5 / 5 SER A 136
SER A 140
PHE A 158
VAL A 182
PHE A 187
 VIV  A 301 (-3.5A)
VIV  A 301 (-3.1A)
VIV  A 301 (-3.9A)
VIV  A 301 (-4.5A)
VIV  A 301 (-3.9A)
 0.28A 1oipA-1r5lA:
43.4		 1oipA-1r5lA:
93.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		12 / 12 TRP A 122
VAL A 132
PHE A 133
ILE A 154
PHE A 158
TRP A 163
ILE A 171
ILE A 179
VAL A 182
VAL A 191
ILE A 194
ILE A 210
 None
VIV  A 301 ( 4.7A)
VIV  A 301 ( 3.9A)
None
VIV  A 301 (-3.9A)
None
None
VIV  A 301 ( 4.0A)
VIV  A 301 (-4.5A)
VIV  A 301 (-4.7A)
VIV  A 301 ( 4.5A)
None
 0.02A 1r5lA-1r5lA:
45.9		 1r5lA-1r5lA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		5 / 12 VAL A 135
PHE A 133
PHE A 158
VAL A 182
ILE A 194
 None
VIV  A 301 ( 3.9A)
VIV  A 301 (-3.9A)
VIV  A 301 (-4.5A)
VIV  A 301 ( 4.5A)
 1.34A 1r5lA-1r5lA:
45.9		 1r5lA-1r5lA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R5L_A_VIVA301_1
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		4 / 4 SER A 136
SER A 140
LEU A 183
PHE A 187
 VIV  A 301 (-3.5A)
VIV  A 301 (-3.1A)
None
VIV  A 301 (-3.9A)
 0.03A 1r5lA-1r5lA:
45.9		 1r5lA-1r5lA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		3 / 3 HIS A 195
HIS A 225
HIS A 236
 None
 0.69A 1rjoA-1r5lA:
undetectable		 1rjoA-1r5lA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		4 / 7 ALA A 168
ILE A 171
ILE A 210
PHE A 207
 None
 0.88A 1upfB-1r5lA:
undetectable		 1upfB-1r5lA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		5 / 12 ILE A 218
ALA A 176
ILE A 179
THR A 215
GLU A 220
 None
None
VIV  A 301 ( 4.0A)
None
None
 1.29A 1vq1A-1r5lA:
undetectable		 1vq1A-1r5lA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		3 / 3 HIS A 195
HIS A 225
HIS A 236
 None
 0.74A 1w2zA-1r5lA:
undetectable		 1w2zA-1r5lA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		3 / 3 HIS A 195
HIS A 225
HIS A 236
 None
 0.69A 1w2zB-1r5lA:
undetectable		 1w2zB-1r5lA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		3 / 3 HIS A 195
HIS A 225
HIS A 236
 None
 0.68A 1w2zC-1r5lA:
undetectable		 1w2zC-1r5lA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		3 / 3 HIS A 195
HIS A 225
HIS A 236
 None
 0.68A 1w2zD-1r5lA:
undetectable		 1w2zD-1r5lA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		3 / 3 HIS A 195
HIS A 225
HIS A 236
 None
 0.71A 2oqeA-1r5lA:
undetectable		 2oqeA-1r5lA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_B_CUB801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		3 / 3 HIS A 195
HIS A 225
HIS A 236
 None
 0.70A 2oqeB-1r5lA:
undetectable		 2oqeB-1r5lA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		3 / 3 HIS A 195
HIS A 225
HIS A 236
 None
 0.72A 2oqeC-1r5lA:
undetectable		 2oqeC-1r5lA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		3 / 3 HIS A 195
HIS A 225
HIS A 236
 None
 0.70A 2oqeD-1r5lA:
undetectable		 2oqeD-1r5lA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		3 / 3 HIS A 195
HIS A 225
HIS A 236
 None
 0.71A 2oqeF-1r5lA:
undetectable		 2oqeF-1r5lA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		3 / 3 ILE A 116
ILE A 197
LEU A  95
 None
 0.40A 2prgA-1r5lA:
undetectable		 2prgA-1r5lA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		4 / 7 ILE A 179
LEU A 183
SER A 140
VAL A 103
 VIV  A 301 ( 4.0A)
None
VIV  A 301 (-3.1A)
None
 0.98A 3r9vA-1r5lA:
undetectable
3r9vB-1r5lA:
undetectable		 3r9vA-1r5lA:
21.78
3r9vB-1r5lA:
21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		11 / 11 TRP A 122
SER A 136
LEU A 137
SER A 140
PHE A 158
ILE A 171
ILE A 179
VAL A 182
LEU A 183
PHE A 187
VAL A 191
 None
VIV  A 301 (-3.5A)
VIV  A 301 ( 4.8A)
VIV  A 301 (-3.1A)
VIV  A 301 (-3.9A)
None
VIV  A 301 ( 4.0A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.7A)
 0.68A 3w67A-1r5lA:
37.7		 3w67A-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		11 / 12 ILE A 119
TRP A 122
SER A 136
LEU A 137
PHE A 158
TRP A 163
ILE A 171
ILE A 179
VAL A 182
LEU A 183
PHE A 187
 None
None
VIV  A 301 (-3.5A)
VIV  A 301 ( 4.8A)
VIV  A 301 (-3.9A)
None
None
VIV  A 301 ( 4.0A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-3.9A)
 0.67A 3w67B-1r5lA:
37.7		 3w67B-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		6 / 12 ILE A 119
TRP A 122
SER A 136
LEU A 137
VAL A 191
PHE A 158
 None
None
VIV  A 301 (-3.5A)
VIV  A 301 ( 4.8A)
VIV  A 301 (-4.7A)
VIV  A 301 (-3.9A)
 1.49A 3w67B-1r5lA:
37.7		 3w67B-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		12 / 12 TYR A 100
ILE A 119
TRP A 122
VAL A 132
LEU A 137
SER A 140
ALA A 156
PHE A 158
ILE A 179
LEU A 183
PHE A 187
VAL A 191
 None
None
None
VIV  A 301 ( 4.7A)
VIV  A 301 ( 4.8A)
VIV  A 301 (-3.1A)
VIV  A 301 ( 4.4A)
VIV  A 301 (-3.9A)
VIV  A 301 ( 4.0A)
None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.7A)
 0.54A 3w67C-1r5lA:
37.3		 3w67C-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		9 / 12 VAL A 132
SER A 136
LEU A 137
SER A 140
PHE A 158
VAL A 182
PHE A 187
ILE A 194
LEU A 196
 VIV  A 301 ( 4.7A)
VIV  A 301 (-3.5A)
VIV  A 301 ( 4.8A)
VIV  A 301 (-3.1A)
VIV  A 301 (-3.9A)
VIV  A 301 (-4.5A)
VIV  A 301 (-3.9A)
VIV  A 301 ( 4.5A)
None
 0.55A 3w67D-1r5lA:
37.0		 3w67D-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		11 / 12 VAL A 132
SER A 136
SER A 140
PHE A 158
ILE A 171
ILE A 179
VAL A 182
LEU A 183
PHE A 187
ILE A 194
LEU A 196
 VIV  A 301 ( 4.7A)
VIV  A 301 (-3.5A)
VIV  A 301 (-3.1A)
VIV  A 301 (-3.9A)
None
VIV  A 301 ( 4.0A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-3.9A)
VIV  A 301 ( 4.5A)
None
 0.51A 3w67D-1r5lA:
37.0		 3w67D-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		12 / 12 TYR A 100
TRP A 122
VAL A 132
SER A 136
LEU A 137
SER A 140
PHE A 158
ILE A 179
VAL A 182
LEU A 183
PHE A 187
VAL A 191
 None
None
VIV  A 301 ( 4.7A)
VIV  A 301 (-3.5A)
VIV  A 301 ( 4.8A)
VIV  A 301 (-3.1A)
VIV  A 301 (-3.9A)
VIV  A 301 ( 4.0A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.7A)
 0.44A 3w68A-1r5lA:
38.7		 3w68A-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		9 / 12 TYR A 100
ILE A 119
TRP A 122
VAL A 132
SER A 136
LEU A 137
PHE A 158
PHE A 187
VAL A 191
 None
None
None
VIV  A 301 ( 4.7A)
VIV  A 301 (-3.5A)
VIV  A 301 ( 4.8A)
VIV  A 301 (-3.9A)
VIV  A 301 (-3.9A)
VIV  A 301 (-4.7A)
 0.45A 3w68B-1r5lA:
37.9		 3w68B-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		9 / 12 TYR A 100
ILE A 119
TRP A 122
VAL A 132
SER A 136
LEU A 137
VAL A 191
PHE A 158
PHE A 187
 None
None
None
VIV  A 301 ( 4.7A)
VIV  A 301 (-3.5A)
VIV  A 301 ( 4.8A)
VIV  A 301 (-4.7A)
VIV  A 301 (-3.9A)
VIV  A 301 (-3.9A)
 1.40A 3w68B-1r5lA:
37.9		 3w68B-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		10 / 12 TYR A 100
ILE A 119
TRP A 122
VAL A 132
SER A 136
PHE A 158
ILE A 179
LEU A 183
PHE A 187
VAL A 191
 None
None
None
VIV  A 301 ( 4.7A)
VIV  A 301 (-3.5A)
VIV  A 301 (-3.9A)
VIV  A 301 ( 4.0A)
None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.7A)
 0.38A 3w68B-1r5lA:
37.9		 3w68B-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		10 / 12 ILE A 119
TRP A 122
VAL A 132
PHE A 158
ILE A 171
ILE A 179
VAL A 182
LEU A 183
PHE A 187
VAL A 191
 None
None
VIV  A 301 ( 4.7A)
VIV  A 301 (-3.9A)
None
VIV  A 301 ( 4.0A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.7A)
 0.29A 3w68C-1r5lA:
37.3		 3w68C-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		5 / 12 ILE A 119
TRP A 122
VAL A 132
VAL A 191
PHE A 158
 None
None
VIV  A 301 ( 4.7A)
VIV  A 301 (-4.7A)
VIV  A 301 (-3.9A)
 1.16A 3w68C-1r5lA:
37.3		 3w68C-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		8 / 12 ILE A 119
VAL A 132
LEU A 137
PHE A 158
VAL A 182
LEU A 183
PHE A 187
VAL A 191
 None
VIV  A 301 ( 4.7A)
VIV  A 301 ( 4.8A)
VIV  A 301 (-3.9A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.7A)
 0.52A 3w68C-1r5lA:
37.3		 3w68C-1r5lA:
89.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		11 / 12 TYR A 100
TRP A 122
VAL A 132
LEU A 137
PHE A 158
ILE A 171
ILE A 179
VAL A 182
LEU A 183
PHE A 187
VAL A 191
 None
None
VIV  A 301 ( 4.7A)
VIV  A 301 ( 4.8A)
VIV  A 301 (-3.9A)
None
VIV  A 301 ( 4.0A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.7A)
 0.50A 3w68D-1r5lA:
36.8		 3w68D-1r5lA:
89.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		3 / 3 CYH A 256
ASN A 261
LYS A  97
 None
 0.72A 4k50A-1r5lA:
undetectable		 4k50A-1r5lA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		5 / 12 ILE A 143
LEU A 115
ILE A 263
LEU A  96
GLY A  99
 None
 1.17A 5ienA-1r5lA:
undetectable		 5ienA-1r5lA:
18.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		12 / 12 ILE A 119
VAL A 132
ILE A 154
PHE A 158
TRP A 163
ILE A 179
VAL A 182
LEU A 183
PHE A 187
VAL A 191
ILE A 194
PHE A 203
 None
VIV  A 301 ( 4.7A)
None
VIV  A 301 (-3.9A)
None
VIV  A 301 ( 4.0A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.7A)
VIV  A 301 ( 4.5A)
None
 0.20A 5mueA-1r5lA:
39.2		 5mueA-1r5lA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		6 / 12 VAL A 135
PHE A 158
VAL A 182
LEU A 183
VAL A 191
ILE A 194
 None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-4.7A)
VIV  A 301 ( 4.5A)
 1.21A 5mueA-1r5lA:
39.2		 5mueA-1r5lA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		12 / 12 ILE A 119
VAL A 132
LEU A 137
ILE A 154
TRP A 163
ILE A 179
VAL A 182
LEU A 183
PHE A 187
VAL A 191
ILE A 194
PHE A 203
 None
VIV  A 301 ( 4.7A)
VIV  A 301 ( 4.8A)
None
None
VIV  A 301 ( 4.0A)
VIV  A 301 (-4.5A)
None
VIV  A 301 (-3.9A)
VIV  A 301 (-4.7A)
VIV  A 301 ( 4.5A)
None
 0.42A 5mugA-1r5lA:
37.0		 5mugA-1r5lA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		3 / 3 SER A 136
SER A 140
PHE A 158
 VIV  A 301 (-3.5A)
VIV  A 301 (-3.1A)
VIV  A 301 (-3.9A)
 0.15A 5mugA-1r5lA:
37.0		 5mugA-1r5lA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		4 / 6 ARG A  54
ARG A  57
ALA A  58
PRO A 188
 None
 1.22A 5odqA-1r5lA:
undetectable		 5odqA-1r5lA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		5 / 12 PHE A 237
PHE A 158
ALA A 176
ALA A 180
THR A 184
 None
VIV  A 301 (-3.9A)
None
None
None
 1.24A 5tl8A-1r5lA:
undetectable		 5tl8A-1r5lA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		4 / 6 ILE A 197
ILE A 154
PHE A 237
HIS A 236
 None
 0.91A 5vkqB-1r5lA:
undetectable
5vkqC-1r5lA:
undetectable		 5vkqB-1r5lA:
9.57
5vkqC-1r5lA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		4 / 6 ILE A 197
ILE A 154
PHE A 237
HIS A 236
 None
 0.90A 5vkqC-1r5lA:
undetectable
5vkqD-1r5lA:
undetectable		 5vkqC-1r5lA:
9.57
5vkqD-1r5lA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		4 / 4 HIS A 195
HIS A 236
HIS A 225
HIS A 223
 None
 1.09A 5zrdC-1r5lA:
undetectable		 5zrdC-1r5lA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		4 / 4 HIS A 195
HIS A 236
HIS A 225
HIS A 223
 None
 1.07A 5zrdD-1r5lA:
undetectable		 5zrdD-1r5lA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11801_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens) 		4 / 4 ARG A 221
ARG A 192
GLY A 111
ARG A 107
 None
 1.49A 6az3P-1r5lA:
0.0		 6az3P-1r5lA:
11.60