SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r5m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 1r5m SIR4-INTERACTING
PROTEIN SIF2
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 166
LEU A 184
ALA A 204
LEU A 206
 None
 0.79A 1hwiD-1r5mA:
undetectable		 1hwiD-1r5mA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 1r5m SIR4-INTERACTING
PROTEIN SIF2
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 333
LEU A 374
PRO A 335
GLU A 366
 None
 1.03A 1jtvA-1r5mA:
undetectable		 1jtvA-1r5mA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 1r5m SIR4-INTERACTING
PROTEIN SIF2
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 301
GLU A 300
ILE A 334
TYR A 344
 None
 0.94A 1qvtA-1r5mA:
undetectable		 1qvtA-1r5mA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 1r5m SIR4-INTERACTING
PROTEIN SIF2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 374
LEU A 375
ILE A 341
ARG A 384
 None
 0.91A 2rlfA-1r5mA:
undetectable
2rlfB-1r5mA:
undetectable		 2rlfA-1r5mA:
7.84
2rlfB-1r5mA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 1r5m SIR4-INTERACTING
PROTEIN SIF2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 374
LEU A 375
ILE A 341
ARG A 384
 None
 1.00A 2rlfC-1r5mA:
undetectable
2rlfD-1r5mA:
undetectable		 2rlfC-1r5mA:
7.84
2rlfD-1r5mA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1r5m SIR4-INTERACTING
PROTEIN SIF2
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 445
SER A 363
ASP A 421
SER A 417
 None
 1.16A 2zw9B-1r5mA:
6.5		 2zw9B-1r5mA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 1r5m SIR4-INTERACTING
PROTEIN SIF2
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 501
TYR A 525
ASP A 505
ASP A 463
ILE A 509
 None
 1.49A 3b7pA-1r5mA:
2.3		 3b7pA-1r5mA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 1r5m SIR4-INTERACTING
PROTEIN SIF2
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 501
TYR A 525
ASP A 505
ASP A 463
ILE A 509
 None
 1.48A 3b7pC-1r5mA:
undetectable		 3b7pC-1r5mA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1r5m SIR4-INTERACTING
PROTEIN SIF2
(Saccharomyces
cerevisiae) 		3 / 3 ILE A 286
PHE A 299
HIS A 275
 None
 0.64A 3h0aA-1r5mA:
undetectable		 3h0aA-1r5mA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1r5m SIR4-INTERACTING
PROTEIN SIF2
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 407
VAL A 415
ILE A 385
SER A 393
PHE A 397
 None
 1.14A 4c49A-1r5mA:
undetectable		 4c49A-1r5mA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 1r5m SIR4-INTERACTING
PROTEIN SIF2
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 387
VAL A 415
LEU A 429
 None
 0.77A 4m2vA-1r5mA:
undetectable		 4m2vA-1r5mA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1r5m SIR4-INTERACTING
PROTEIN SIF2
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 469
GLY A 422
ASP A 421
VAL A 364
 None
 1.16A 4nkvD-1r5mA:
undetectable		 4nkvD-1r5mA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1r5m SIR4-INTERACTING
PROTEIN SIF2
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 356
GLY A 336
LEU A 365
LEU A 374
 None
 0.84A 5hs1A-1r5mA:
undetectable		 5hs1A-1r5mA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 1r5m SIR4-INTERACTING
PROTEIN SIF2
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 383
GLY A 399
ILE A 416
LEU A 426
LEU A 437
 None
 1.03A 5l0zB-1r5mA:
undetectable		 5l0zB-1r5mA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1r5m SIR4-INTERACTING
PROTEIN SIF2
(Saccharomyces
cerevisiae) 		4 / 6 LYS A 472
VAL A 468
ILE A 535
LYS A 149
 None
 1.22A 5q1sA-1r5mA:
undetectable		 5q1sA-1r5mA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 1r5m SIR4-INTERACTING
PROTEIN SIF2
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 176
LEU A 226
GLN A 222
VAL A 223
HIS A 208
 None
 1.27A 5ubbA-1r5mA:
undetectable		 5ubbA-1r5mA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1r5m SIR4-INTERACTING
PROTEIN SIF2
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 449
ALA A 458
TYR A 457
ILE A 445
 None
 1.33A 6f6sA-1r5mA:
0.0
6f6sB-1r5mA:
0.0		 6f6sA-1r5mA:
10.75
6f6sB-1r5mA:
12.11