SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r5n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A 317
SER A 450
TYR A 454
 None
 0.75A 1x70A-1r5nA:
undetectable		 1x70A-1r5nA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 508
ILE A 488
GLY A 486
VAL A 501
VAL A 499
 None
 0.99A 2nnkA-1r5nA:
undetectable		 2nnkA-1r5nA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		5 / 9 THR A 585
GLY A 544
THR A 543
ALA A 474
LEU A 532
 None
 1.27A 2npnA-1r5nA:
2.5		 2npnA-1r5nA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		3 / 3 VAL A 580
GLU A 588
GLU A 589
 None
 0.79A 2nv4A-1r5nA:
2.3		 2nv4A-1r5nA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		4 / 8 ILE A 241
LEU A 452
VAL A 434
LEU A 451
 None
 0.89A 2w98B-1r5nA:
undetectable		 2w98B-1r5nA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_1
(HYPOTHETICAL PROTEIN)		 1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		4 / 4 GLY A 486
GLU A 485
ASP A 220
TYR A 639
 None
 1.37A 2yvlC-1r5nA:
undetectable		 2yvlC-1r5nA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		4 / 8 ILE A 244
ALA A 371
ARG A 372
ALA A 413
 None
 0.96A 3hrdA-1r5nA:
undetectable
3hrdB-1r5nA:
undetectable		 3hrdA-1r5nA:
21.97
3hrdB-1r5nA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		5 / 9 PHE A 243
LEU A 451
THR A 262
ILE A 258
PHE A 318
 None
 1.09A 3tbgD-1r5nA:
undetectable		 3tbgD-1r5nA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE A 241
LEU A 455
GLY A 256
GLY A 255
LEU A 451
 None
 1.09A 3vasB-1r5nA:
undetectable		 3vasB-1r5nA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		5 / 8 ALA A 474
ILE A 473
ALA A 490
PHE A 469
LEU A 547
 None
 1.49A 4v1fA-1r5nA:
undetectable
4v1fB-1r5nA:
undetectable		 4v1fA-1r5nA:
9.64
4v1fB-1r5nA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU A 532
LEU A 484
GLU A 485
MET A 471
 None
 0.89A 4ww7A-1r5nA:
0.0		 4ww7A-1r5nA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		5 / 12 ALA A 277
GLY A 256
GLY A 250
LEU A 254
LEU A 259
 None
None
GDP  A 663 (-2.9A)
None
None
 1.15A 5c0oE-1r5nA:
undetectable		 5c0oE-1r5nA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU A 320
ILE A 342
PHE A 311
LEU A 254
 None
 0.83A 5eseA-1r5nA:
undetectable		 5eseA-1r5nA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		4 / 8 TYR A 639
ASP A 220
THR A 585
VAL A 225
 None
 1.30A 5ov9B-1r5nA:
undetectable		 5ov9B-1r5nA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		3 / 3 GLU A 312
ARG A 317
TYR A 310
 None
 0.63A 5trqB-1r5nA:
0.0		 5trqB-1r5nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		3 / 3 THR A 557
THR A 558
ARG A 559
 None
 1.07A 5wm2A-1r5nA:
undetectable		 5wm2A-1r5nA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A 250
GLY A 256
ASP A 266
VAL A 265
ILE A 273
 GDP  A 663 (-2.9A)
None
None
None
None
 0.91A 5wz1A-1r5nA:
undetectable		 5wz1A-1r5nA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A 250
GLY A 256
ASP A 266
VAL A 265
ILE A 273
 GDP  A 663 (-2.9A)
None
None
None
None
 0.93A 5wz1C-1r5nA:
undetectable		 5wz1C-1r5nA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A 250
GLY A 256
ASP A 266
VAL A 265
ILE A 273
 GDP  A 663 (-2.9A)
None
None
None
None
 0.93A 5wz1E-1r5nA:
undetectable		 5wz1E-1r5nA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A 308
PHE A 318
LEU A 321
 None
 0.77A 5x1bC-1r5nA:
undetectable		 5x1bC-1r5nA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
(Schizosaccharomy
ces
pombe) 		4 / 8 HIS A 555
GLU A 632
ASP A 636
GLU A 635
 None
 1.22A 6mn4D-1r5nA:
undetectable		 6mn4D-1r5nA:
19.11