SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r66'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		4 / 7 SER A 138
ASP A 284
GLU A 247
GLU A 216
 None
 1.01A 1knyA-1r66A:
0.0
1knyB-1r66A:
0.0		 1knyA-1r66A:
22.38
1knyB-1r66A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		4 / 8 SER A 138
ASP A 284
GLU A 247
GLU A 216
 None
 0.90A 1knyA-1r66A:
0.0
1knyB-1r66A:
0.0		 1knyA-1r66A:
22.38
1knyB-1r66A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1872_0
(FPRA)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		4 / 5 SER A 154
ASN A 103
ALA A  85
GLU A  86
 None
None
NAD  A 900 (-3.4A)
None
 1.39A 1lqtA-1r66A:
5.7
1lqtB-1r66A:
5.6		 1lqtA-1r66A:
23.68
1lqtB-1r66A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1429_0
(FPRA)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		4 / 5 SER A 154
ASN A 103
ALA A  85
GLU A  86
 None
None
NAD  A 900 (-3.4A)
None
 1.38A 1lquA-1r66A:
5.4
1lquB-1r66A:
5.1		 1lquA-1r66A:
23.68
1lquB-1r66A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		4 / 6 ILE A 242
GLY A 226
ALA A 228
HIS A 223
 None
 1.00A 1wmqA-1r66A:
0.0		 1wmqA-1r66A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		4 / 6 ILE A 242
GLY A 226
ALA A 228
HIS A 223
 None
 1.01A 1wmqB-1r66A:
undetectable		 1wmqB-1r66A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		4 / 6 ILE A 242
GLY A 226
ALA A 228
HIS A 223
 None
 0.99A 1wpuA-1r66A:
undetectable		 1wpuA-1r66A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		4 / 6 ILE A 242
GLY A 226
ALA A 228
HIS A 223
 None
 1.00A 1wpuB-1r66A:
0.0		 1wpuB-1r66A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_A_AZMA263_1
(CARBONIC ANHYDRASE 9)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		5 / 11 HIS A 124
VAL A 122
VAL A  77
LEU A 110
THR A 107
 None
 1.20A 3iaiA-1r66A:
undetectable		 3iaiA-1r66A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_B_AZMB263_1
(CARBONIC ANHYDRASE 9)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		5 / 11 HIS A 124
VAL A 122
VAL A  77
LEU A 110
THR A 107
 None
 1.21A 3iaiB-1r66A:
undetectable		 3iaiB-1r66A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_C_AZMC263_1
(CARBONIC ANHYDRASE 9)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		5 / 11 HIS A 124
VAL A 122
VAL A  77
LEU A 110
THR A 107
 None
 1.20A 3iaiC-1r66A:
undetectable		 3iaiC-1r66A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_D_AZMD263_1
(CARBONIC ANHYDRASE 9)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		5 / 11 HIS A 124
VAL A 122
VAL A  77
LEU A 110
THR A 107
 None
 1.20A 3iaiD-1r66A:
undetectable		 3iaiD-1r66A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KWA_A_SPMA300_1
(CARBONIC ANHYDRASE 2)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		5 / 11 HIS A 124
VAL A 122
VAL A 173
LEU A 110
THR A 107
 None
 1.36A 3kwaA-1r66A:
undetectable		 3kwaA-1r66A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		3 / 3 SER A 149
ASP A 278
ASN A 213
 None
None
TYD  A 901 ( 4.8A)
 0.83A 3lslA-1r66A:
undetectable
3lslD-1r66A:
undetectable		 3lslA-1r66A:
21.01
3lslD-1r66A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		5 / 12 LEU A  39
THR A  40
GLY A   7
LEU A  48
LEU A  36
 None
NAD  A 900 (-3.3A)
NAD  A 900 ( 3.7A)
None
None
 1.10A 3p5nA-1r66A:
undetectable		 3p5nA-1r66A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		5 / 12 LEU A  39
THR A  40
GLY A   7
LEU A  48
LEU A  36
 None
NAD  A 900 (-3.3A)
NAD  A 900 ( 3.7A)
None
None
 1.10A 3p5nB-1r66A:
undetectable		 3p5nB-1r66A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		6 / 12 GLY A 244
GLY A 226
GLY A 243
GLU A 289
ASP A  27
ASP A 222
 None
 1.37A 3p97C-1r66A:
5.3		 3p97C-1r66A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		4 / 7 GLY A 106
THR A 107
SER A  38
THR A  40
 None
None
NAD  A 900 (-3.2A)
NAD  A 900 (-3.3A)
 0.69A 4ac9C-1r66A:
5.5		 4ac9C-1r66A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		6 / 12 GLY A 244
GLY A 226
GLY A 243
GLU A 289
ASP A  27
ASP A 222
 None
 1.39A 5ec8C-1r66A:
5.4		 5ec8C-1r66A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		5 / 9 TYR A 185
GLY A 183
HIS A  15
ASP A 221
HIS A 219
 None
 1.17A 5f8yA-1r66A:
0.0		 5f8yA-1r66A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		5 / 9 TYR A 185
GLY A 183
HIS A  15
ASP A 221
HIS A 219
 None
 1.21A 5f8yA-1r66A:
0.0		 5f8yA-1r66A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		5 / 9 TYR A 185
GLY A 183
HIS A  15
ASP A 221
HIS A 219
 None
 1.18A 5f8yB-1r66A:
0.0		 5f8yB-1r66A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		5 / 9 TYR A 185
GLY A 183
HIS A  15
ASP A 221
HIS A 219
 None
 1.15A 5f8yB-1r66A:
0.0		 5f8yB-1r66A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		5 / 11 ALA A 228
GLY A 234
GLY A 233
ALA A 232
ASP A  27
 None
 0.93A 5lf7K-1r66A:
undetectable
5lf7L-1r66A:
undetectable		 5lf7K-1r66A:
23.23
5lf7L-1r66A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		5 / 11 ALA A 228
GLY A 234
GLY A 233
ALA A 232
ASP A  27
 None
 0.93A 5lf7Y-1r66A:
undetectable
5lf7Z-1r66A:
undetectable		 5lf7Y-1r66A:
23.23
5lf7Z-1r66A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		5 / 12 LEU A 231
PHE A  83
PHE A  16
THR A 107
ALA A 114
 None
 1.13A 5veuA-1r66A:
0.0		 5veuA-1r66A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE
(Streptomyces
venezuelae) 		5 / 12 ILE A 256
LEU A 261
VAL A 308
LEU A 248
LEU A 246
 None
 1.23A 6b54A-1r66A:
2.1		 6b54A-1r66A:
19.58