SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r6b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 12 ILE X 291
ALA X 293
PHE X 331
LEU X 211
ILE X 287
 None
 1.04A 1cd2A-1r6bX:
undetectable		 1cd2A-1r6bX:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 12 GLY X 406
ALA X 405
ILE X 433
ILE X 399
ILE X 426
 None
None
None
ADP  X 780 (-4.7A)
None
 0.88A 1hxbA-1r6bX:
undetectable		 1hxbA-1r6bX:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		4 / 8 VAL X 662
VAL X 731
VAL X 733
LEU X 712
 None
 0.91A 1igxA-1r6bX:
0.8		 1igxA-1r6bX:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		4 / 8 PHE X 493
LEU X 456
VAL X 560
VAL X 600
 None
 0.79A 1iwiA-1r6bX:
undetectable		 1iwiA-1r6bX:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 12 ILE X 291
ALA X 293
PHE X 331
LEU X 211
ILE X 287
 None
 1.02A 1rb2B-1r6bX:
undetectable		 1rb2B-1r6bX:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		4 / 8 PHE X 493
LEU X 456
VAL X 560
VAL X 600
 None
 0.82A 1t86A-1r6bX:
undetectable		 1t86A-1r6bX:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 12 LEU X 176
ASN X 177
ILE X 281
SER X 280
ALA X 228
 None
 1.12A 2ejtA-1r6bX:
undetectable		 2ejtA-1r6bX:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 12 GLY X 406
ALA X 405
ILE X 433
ILE X 399
ILE X 426
 None
None
None
ADP  X 780 (-4.7A)
None
 0.95A 2nmyB-1r6bX:
undetectable		 2nmyB-1r6bX:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		3 / 3 LEU X 109
LEU X  58
PHE X 113
 None
 0.71A 2pgrA-1r6bX:
undetectable		 2pgrA-1r6bX:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 12 LEU X  54
LEU X  31
SER X 118
VAL X  87
VAL X 134
 None
 1.21A 2po7A-1r6bX:
2.0		 2po7A-1r6bX:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		4 / 8 PHE X 493
LEU X 456
VAL X 560
VAL X 600
 None
 0.70A 2zujA-1r6bX:
undetectable		 2zujA-1r6bX:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 12 GLY X 406
ALA X 405
ILE X 433
ILE X 399
ILE X 426
 None
None
None
ADP  X 780 (-4.7A)
None
 0.92A 3d1xB-1r6bX:
undetectable		 3d1xB-1r6bX:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 12 LEU X 282
GLN X 273
LEU X 169
THR X 174
LEU X 271
 None
 1.29A 3fsuA-1r6bX:
undetectable		 3fsuA-1r6bX:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 11 GLN X 200
VAL X 201
PRO X 210
ILE X 245
ILE X 223
 None
 1.21A 3ganA-1r6bX:
0.0		 3ganA-1r6bX:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 12 PHE X 283
SER X 247
THR X 174
ALA X 228
LEU X 179
 None
 1.39A 3lcvB-1r6bX:
undetectable		 3lcvB-1r6bX:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		3 / 3 ARG X 697
ASP X 656
GLN X 684
 None
 0.91A 3lcvB-1r6bX:
undetectable		 3lcvB-1r6bX:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 12 GLU X 631
ILE X 632
PHE X 636
ALA X 628
ILE X 647
 None
 1.08A 3ndiA-1r6bX:
undetectable		 3ndiA-1r6bX:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_2
(PROTEASE)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 12 GLY X 406
ALA X 405
ILE X 433
ILE X 399
ILE X 426
 None
None
None
ADP  X 780 (-4.7A)
None
 0.87A 3nduD-1r6bX:
undetectable		 3nduD-1r6bX:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		3 / 3 GLY X 217
GLY X 219
THR X 221
 ADP  X 780 (-3.6A)
ADP  X 780 (-3.1A)
MG  X 782 ( 3.2A)
 0.45A 3si7B-1r6bX:
3.7		 3si7B-1r6bX:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 12 GLY X 406
ALA X 405
ILE X 433
ILE X 399
ILE X 426
 None
None
None
ADP  X 780 (-4.7A)
None
 0.95A 3tkgA-1r6bX:
undetectable		 3tkgA-1r6bX:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 12 GLY X 406
ALA X 405
ILE X 433
ILE X 399
ILE X 426
 None
None
None
ADP  X 780 (-4.7A)
None
 0.94A 3tkgC-1r6bX:
undetectable		 3tkgC-1r6bX:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		4 / 8 ILE X 284
ASP X 285
ILE X 250
GLY X 256
 None
MG  X 782 (-3.7A)
None
None
 0.70A 4ac9C-1r6bX:
undetectable		 4ac9C-1r6bX:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		4 / 8 ILE X 284
ASP X 285
ILE X 250
GLY X 256
 None
MG  X 782 (-3.7A)
None
None
 0.72A 4acaC-1r6bX:
undetectable		 4acaC-1r6bX:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		4 / 6 THR X 221
GLY X 219
ILE X 346
LEU X 188
 MG  X 782 ( 3.2A)
ADP  X 780 (-3.1A)
None
ADP  X 780 (-4.5A)
 1.24A 4acaC-1r6bX:
undetectable		 4acaC-1r6bX:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		4 / 7 PHE X 493
LEU X 456
VAL X 560
VAL X 600
 None
 0.81A 4cp4A-1r6bX:
undetectable		 4cp4A-1r6bX:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		4 / 8 ASP X 285
ASP X 396
ASP X 400
GLU X 286
 MG  X 782 (-3.7A)
ADP  X 780 (-4.1A)
None
MG  X 782 ( 4.4A)
 0.87A 4feuD-1r6bX:
undetectable		 4feuD-1r6bX:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		4 / 7 ASP X 285
ASP X 396
GLU X 225
GLU X 286
 MG  X 782 (-3.7A)
ADP  X 780 (-4.1A)
None
MG  X 782 ( 4.4A)
 0.91A 4fevB-1r6bX:
undetectable		 4fevB-1r6bX:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		4 / 7 ASP X 285
ASP X 396
GLU X 225
GLU X 286
 MG  X 782 (-3.7A)
ADP  X 780 (-4.1A)
None
MG  X 782 ( 4.4A)
 0.84A 4fewB-1r6bX:
0.0		 4fewB-1r6bX:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		4 / 8 ASP X 285
ASP X 396
GLU X 225
GLU X 286
 MG  X 782 (-3.7A)
ADP  X 780 (-4.1A)
None
MG  X 782 ( 4.4A)
 0.91A 4gkhD-1r6bX:
undetectable		 4gkhD-1r6bX:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 12 ILE X 291
ALA X 293
PHE X 331
LEU X 211
ILE X 287
 None
 1.08A 4kjkA-1r6bX:
undetectable		 4kjkA-1r6bX:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 12 ILE X 291
ALA X 293
PHE X 331
LEU X 211
ILE X 287
 None
 1.07A 4km2A-1r6bX:
undetectable		 4km2A-1r6bX:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 9 VAL X 318
ILE X 319
LEU X 212
ILE X 281
GLY X 226
 None
 1.11A 4kukA-1r6bX:
undetectable		 4kukA-1r6bX:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		4 / 8 PHE X 493
LEU X 456
VAL X 560
VAL X 600
 None
 0.82A 4l4bA-1r6bX:
0.0		 4l4bA-1r6bX:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 10 PHE X 263
ALA X 303
ASP X 302
PHE X 267
GLY X 299
 None
 1.29A 4xp1A-1r6bX:
undetectable		 4xp1A-1r6bX:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		4 / 8 TRP X 689
TYR X 744
HIS X 659
LEU X 716
 None
 1.23A 5b1aA-1r6bX:
0.1
5b1aC-1r6bX:
undetectable
5b1aP-1r6bX:
undetectable		 5b1aA-1r6bX:
20.94
5b1aC-1r6bX:
16.04
5b1aP-1r6bX:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 12 ALA X 749
GLY X 728
GLY X 677
LEU X 673
LEU X 721
 None
 1.06A 5c0oH-1r6bX:
undetectable		 5c0oH-1r6bX:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 10 ALA X 377
ARG X 408
ALA X 381
VAL X 401
VAL X 429
 None
 1.32A 5eb5B-1r6bX:
undetectable		 5eb5B-1r6bX:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 8 ALA X  91
LEU X  30
LEU X  34
LEU X   2
LEU X  10
 None
 1.18A 5jqbA-1r6bX:
undetectable
5jqbB-1r6bX:
undetectable		 5jqbA-1r6bX:
19.13
5jqbB-1r6bX:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		3 / 3 LYS X 126
LEU X  44
ILE X 112
 None
 0.71A 5kc4A-1r6bX:
undetectable		 5kc4A-1r6bX:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 12 VAL X  27
LEU X  44
ALA X 120
SER X 118
ARG X  55
 None
 1.41A 5nd2B-1r6bX:
undetectable		 5nd2B-1r6bX:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		4 / 8 VAL X 733
LEU X 742
ILE X 708
VAL X 662
 None
 0.75A 5nujA-1r6bX:
0.0		 5nujA-1r6bX:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 9 VAL X 103
LEU X   6
ILE X 112
LEU X  44
ALA X  91
 None
 1.28A 5og9A-1r6bX:
undetectable		 5og9A-1r6bX:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAH_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 12 GLN X 507
VAL X 460
SER X 509
LEU X 516
ARG X 518
 None
ADP  X 781 (-3.8A)
None
None
None
 1.23A 5uahC-1r6bX:
0.0		 5uahC-1r6bX:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 11 ILE X 291
ALA X 293
PHE X 331
LEU X 211
ILE X 287
 None
 1.03A 5z6mA-1r6bX:
undetectable		 5z6mA-1r6bX:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		4 / 8 PHE X 493
LEU X 456
VAL X 560
VAL X 600
 None
 0.83A 6cp4A-1r6bX:
undetectable		 6cp4A-1r6bX:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		3 / 3 VAL X 682
GLU X 681
ILE X 666
 None
 0.48A 6f7lB-1r6bX:
undetectable		 6f7lB-1r6bX:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		4 / 6 LEU X  34
ALA X  40
LEU X  88
SER X   9
 None
 0.95A 6f88B-1r6bX:
0.0		 6f88B-1r6bX:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 11 ILE X 399
TYR X 373
HIS X 369
GLY X 406
ALA X 381
 ADP  X 780 (-4.7A)
None
None
None
None
 1.24A 6ieyA-1r6bX:
undetectable
6ieyB-1r6bX:
undetectable		 6ieyA-1r6bX:
18.72
6ieyB-1r6bX:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 12 LEU X 211
ILE X 287
GLY X 292
PHE X 331
ILE X 290
 None
 1.33A 6qyaB-1r6bX:
0.0		 6qyaB-1r6bX:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 12 LEU X 211
ILE X 287
GLY X 292
PHE X 331
ILE X 290
 None
 1.35A 6qyaD-1r6bX:
0.0		 6qyaD-1r6bX:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1r6b CLPA PROTEIN
(Escherichia
coli) 		5 / 12 ILE X 291
ALA X 293
PHE X 331
LEU X 211
ILE X 287
 None
 1.08A 7dfrA-1r6bX:
undetectable		 7dfrA-1r6bX:
13.06