SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r6m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 176
GLY A 125
ASN A 189
PHE A 210
ARG A 127
 None
PO4  A 242 (-3.6A)
PO4  A 242 ( 4.9A)
None
PO4  A 242 (-3.8A)
 1.13A 1dfoA-1r6mA:
undetectable		 1dfoA-1r6mA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 176
GLY A 125
ASN A 189
PHE A 210
ARG A 127
 None
PO4  A 242 (-3.6A)
PO4  A 242 ( 4.9A)
None
PO4  A 242 (-3.8A)
 1.12A 1dfoB-1r6mA:
undetectable		 1dfoB-1r6mA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 176
GLY A 125
ASN A 189
PHE A 210
ARG A 127
 None
PO4  A 242 (-3.6A)
PO4  A 242 ( 4.9A)
None
PO4  A 242 (-3.8A)
 1.12A 1dfoC-1r6mA:
undetectable		 1dfoC-1r6mA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 176
GLY A 125
ASN A 189
PHE A 210
ARG A 127
 None
PO4  A 242 (-3.6A)
PO4  A 242 ( 4.9A)
None
PO4  A 242 (-3.8A)
 1.13A 1dfoD-1r6mA:
undetectable		 1dfoD-1r6mA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 176
GLY A 125
ASN A 189
PHE A 210
ARG A 127
 None
PO4  A 242 (-3.6A)
PO4  A 242 ( 4.9A)
None
PO4  A 242 (-3.8A)
 1.12A 1eqbA-1r6mA:
undetectable		 1eqbA-1r6mA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 176
GLY A 125
ASN A 189
PHE A 210
ARG A 127
 None
PO4  A 242 (-3.6A)
PO4  A 242 ( 4.9A)
None
PO4  A 242 (-3.8A)
 1.12A 1eqbB-1r6mA:
undetectable		 1eqbB-1r6mA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 176
GLY A 125
ASN A 189
PHE A 210
ARG A 127
 None
PO4  A 242 (-3.6A)
PO4  A 242 ( 4.9A)
None
PO4  A 242 (-3.8A)
 1.12A 1eqbC-1r6mA:
undetectable		 1eqbC-1r6mA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 176
GLY A 125
ASN A 189
PHE A 210
ARG A 127
 None
PO4  A 242 (-3.6A)
PO4  A 242 ( 4.9A)
None
PO4  A 242 (-3.8A)
 1.11A 1eqbD-1r6mA:
undetectable		 1eqbD-1r6mA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 129
ALA A 162
GLY A 125
LEU A 188
GLN A 202
 None
None
PO4  A 242 (-3.6A)
None
None
 1.03A 1qabF-1r6mA:
0.0		 1qabF-1r6mA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		4 / 7 GLY A 133
GLN A 233
MET A 159
VAL A  29
 None
 1.08A 1rxcF-1r6mA:
undetectable		 1rxcF-1r6mA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		4 / 7 GLY A 133
GLN A 233
MET A 159
VAL A  29
 None
 1.06A 1rxcL-1r6mA:
undetectable		 1rxcL-1r6mA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 215
LEU A 221
ALA A 222
LEU A 176
ARG A   3
 None
 1.30A 2aa5B-1r6mA:
undetectable		 2aa5B-1r6mA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 187
VAL A 173
PRO A   4
 None
 0.76A 2avvA-1r6mA:
undetectable		 2avvA-1r6mA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 108
PRO A 155
LEU A 151
ARG A 148
 None
 1.33A 2hrcA-1r6mA:
undetectable		 2hrcA-1r6mA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 215
LEU A 221
ALA A 222
LEU A 176
ARG A   3
 None
 1.20A 2oaxB-1r6mA:
undetectable		 2oaxB-1r6mA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 215
LEU A 221
ALA A 222
LEU A 176
ARG A   3
 None
 1.19A 2oaxD-1r6mA:
undetectable		 2oaxD-1r6mA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 215
LEU A 221
ALA A 222
LEU A 176
ARG A   3
 None
 1.22A 2oaxE-1r6mA:
undetectable		 2oaxE-1r6mA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		4 / 8 VAL A 119
GLY A 125
THR A 126
ALA A 129
 None
PO4  A 242 (-3.6A)
PO4  A 242 (-2.8A)
None
 0.64A 3aruA-1r6mA:
undetectable		 3aruA-1r6mA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 108
PRO A 155
LEU A 151
ARG A 148
 None
 1.32A 3hcoB-1r6mA:
undetectable		 3hcoB-1r6mA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		4 / 6 VAL A  31
LEU A  60
ILE A 199
ALA A 134
 None
 0.91A 3kk6B-1r6mA:
undetectable		 3kk6B-1r6mA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 133
GLN A 233
MET A 159
VAL A  29
 None
 1.08A 3kvvA-1r6mA:
undetectable		 3kvvA-1r6mA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 133
GLN A 233
MET A 159
VAL A  29
 None
 1.11A 3kvvB-1r6mA:
undetectable		 3kvvB-1r6mA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 133
GLN A 233
MET A 159
VAL A  29
 None
 1.10A 3kvvC-1r6mA:
undetectable		 3kvvC-1r6mA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 133
GLN A 233
MET A 159
VAL A  29
 None
 1.14A 3kvvD-1r6mA:
undetectable		 3kvvD-1r6mA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 133
GLN A 233
MET A 159
VAL A  29
 None
 1.10A 3kvvE-1r6mA:
undetectable		 3kvvE-1r6mA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 133
GLN A 233
MET A 159
VAL A  29
 None
 1.11A 3kvvF-1r6mA:
undetectable		 3kvvF-1r6mA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 236
LEU A 232
GLY A 133
ALA A 102
LEU A 156
 None
 1.30A 3tm4A-1r6mA:
undetectable		 3tm4A-1r6mA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 236
LEU A 232
GLY A 133
ALA A 102
LEU A 156
 None
 1.32A 3tm4B-1r6mA:
undetectable		 3tm4B-1r6mA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		5 / 7 ARG A 100
LEU A  60
ALA A 134
VAL A  38
ILE A 115
 None
 1.42A 3wsjB-1r6mA:
undetectable		 3wsjB-1r6mA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  95
GLY A 125
THR A  36
VAL A  38
VAL A 119
 None
PO4  A 242 (-3.6A)
None
None
None
 1.06A 4c9lA-1r6mA:
undetectable		 4c9lA-1r6mA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		3 / 3 TYR A  64
THR A 126
GLU A  90
 None
PO4  A 242 (-2.8A)
None
 0.83A 4df3A-1r6mA:
undetectable		 4df3A-1r6mA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		3 / 3 TYR A  64
THR A 126
GLU A  90
 None
PO4  A 242 (-2.8A)
None
 0.81A 4df3B-1r6mA:
undetectable		 4df3B-1r6mA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 133
GLN A 233
MET A 159
VAL A  29
 None
 1.09A 4e1vF-1r6mA:
undetectable		 4e1vF-1r6mA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		4 / 4 ILE A  17
VAL A  38
VAL A  29
ARG A  19
 None
 0.97A 4m6tA-1r6mA:
0.0		 4m6tA-1r6mA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  12
MET A 218
LEU A 176
ILE A  15
 None
 0.99A 4okwA-1r6mA:
undetectable		 4okwA-1r6mA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 194
LYS A 157
LEU A 103
 None
 1.03A 4ptjA-1r6mA:
undetectable		 4ptjA-1r6mA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 123
GLY A 124
ASP A  35
ASP A 177
 None
PO4  A 242 ( 4.1A)
None
None
 1.07A 5no9D-1r6mA:
0.0		 5no9D-1r6mA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		5 / 10 VAL A 190
GLY A 203
LEU A 174
LEU A 221
ALA A 222
 None
 1.03A 5vm8B-1r6mA:
undetectable		 5vm8B-1r6mA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 1r6m RIBONUCLEASE PH
(Pseudomonas
aeruginosa) 		3 / 3 PHE A 230
ARG A 234
GLN A 233
 None
 1.08A 6g1pB-1r6mA:
undetectable		 6g1pB-1r6mA:
23.01