SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r6u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 11 GLY A 161
HIS A 170
HIS A 173
ASP A 312
GLN A 313
 TYM  A 501 (-3.6A)
None
TYM  A 501 (-4.6A)
TYM  A 501 (-3.2A)
TYM  A 501 (-3.6A)
 0.94A 1jzsA-1r6uA:
undetectable		 1jzsA-1r6uA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		3 / 3 LEU A 434
VAL A 437
LEU A 441
 None
 0.45A 1mz9B-1r6uA:
undetectable		 1mz9B-1r6uA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 7 ASP A 198
MET A 195
ASP A 197
ASP A 237
 None
 1.45A 1t03A-1r6uA:
undetectable		 1t03A-1r6uA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 ALA A 285
ILE A 254
VAL A 258
ILE A 278
PHE A 267
 None
 0.99A 1xozA-1r6uA:
undetectable		 1xozA-1r6uA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		3 / 3 LEU A 438
LEU A 174
MET A 350
 None
 0.77A 1ya3B-1r6uA:
0.0		 1ya3B-1r6uA:
19.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 THR A 160
GLY A 161
GLY A 163
GLN A 194
GLN A 284
 TYM  A 501 (-4.5A)
TYM  A 501 (-3.6A)
TYM  A 501 (-3.6A)
TYM  A 501 (-4.0A)
TYM  A 501 (-3.2A)
 1.01A 2akeA-1r6uA:
56.8		 2akeA-1r6uA:
97.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		12 / 12 TYR A 159
THR A 160
GLY A 161
GLY A 163
THR A 196
GLU A 199
LYS A 200
GLN A 284
ILE A 307
CYH A 309
GLN A 313
PHE A 317
 TYM  A 501 (-3.8A)
TYM  A 501 (-4.5A)
TYM  A 501 (-3.6A)
TYM  A 501 (-3.6A)
TYM  A 501 ( 3.8A)
TYM  A 501 (-3.0A)
None
TYM  A 501 (-3.2A)
TYM  A 501 (-4.8A)
TYM  A 501 (-4.8A)
TYM  A 501 (-3.6A)
TYM  A 501 (-4.7A)
 0.41A 2akeA-1r6uA:
56.8		 2akeA-1r6uA:
97.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 THR A 160
GLY A 161
GLY A 163
GLN A 194
GLN A 284
 TYM  A 501 (-4.5A)
TYM  A 501 (-3.6A)
TYM  A 501 (-3.6A)
TYM  A 501 (-4.0A)
TYM  A 501 (-3.2A)
 0.98A 2azxA-1r6uA:
63.6		 2azxA-1r6uA:
88.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 THR A 160
GLY A 161
GLY A 163
GLN A 284
GLN A 313
 TYM  A 501 (-4.5A)
TYM  A 501 (-3.6A)
TYM  A 501 (-3.6A)
TYM  A 501 (-3.2A)
TYM  A 501 (-3.6A)
 1.04A 2azxA-1r6uA:
63.6		 2azxA-1r6uA:
88.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		12 / 12 TYR A 159
THR A 160
GLY A 161
GLY A 163
GLN A 194
THR A 196
GLU A 199
GLN A 284
ILE A 307
CYH A 309
GLN A 313
PHE A 317
 TYM  A 501 (-3.8A)
TYM  A 501 (-4.5A)
TYM  A 501 (-3.6A)
TYM  A 501 (-3.6A)
TYM  A 501 (-4.0A)
TYM  A 501 ( 3.8A)
TYM  A 501 (-3.0A)
TYM  A 501 (-3.2A)
TYM  A 501 (-4.8A)
TYM  A 501 (-4.8A)
TYM  A 501 (-3.6A)
TYM  A 501 (-4.7A)
 0.29A 2azxA-1r6uA:
63.6		 2azxA-1r6uA:
88.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 8 ILE A 178
LEU A 441
HIS A 445
ARG A 448
 GOL  A 602 (-4.1A)
None
None
None
 0.82A 2azxA-1r6uA:
63.6		 2azxA-1r6uA:
88.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		6 / 8 LEU A 174
ILE A 178
PHE A 406
ILE A 442
HIS A 445
ARG A 448
 None
GOL  A 602 (-4.1A)
None
None
None
None
 0.50A 2azxA-1r6uA:
63.6		 2azxA-1r6uA:
88.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 THR A 160
GLY A 161
GLY A 163
GLN A 194
GLN A 284
 TYM  A 501 (-4.5A)
TYM  A 501 (-3.6A)
TYM  A 501 (-3.6A)
TYM  A 501 (-4.0A)
TYM  A 501 (-3.2A)
 0.97A 2azxB-1r6uA:
63.4		 2azxB-1r6uA:
88.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 THR A 160
GLY A 161
GLY A 163
GLN A 284
GLN A 313
 TYM  A 501 (-4.5A)
TYM  A 501 (-3.6A)
TYM  A 501 (-3.6A)
TYM  A 501 (-3.2A)
TYM  A 501 (-3.6A)
 1.02A 2azxB-1r6uA:
63.4		 2azxB-1r6uA:
88.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		12 / 12 TYR A 159
THR A 160
GLY A 161
GLY A 163
GLN A 194
THR A 196
GLU A 199
GLN A 284
ILE A 307
CYH A 309
GLN A 313
PHE A 317
 TYM  A 501 (-3.8A)
TYM  A 501 (-4.5A)
TYM  A 501 (-3.6A)
TYM  A 501 (-3.6A)
TYM  A 501 (-4.0A)
TYM  A 501 ( 3.8A)
TYM  A 501 (-3.0A)
TYM  A 501 (-3.2A)
TYM  A 501 (-4.8A)
TYM  A 501 (-4.8A)
TYM  A 501 (-3.6A)
TYM  A 501 (-4.7A)
 0.29A 2azxB-1r6uA:
63.4		 2azxB-1r6uA:
88.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		11 / 11 TYR A 159
GLY A 161
GLY A 163
GLN A 194
THR A 196
GLU A 199
GLN A 284
ILE A 307
CYH A 309
GLN A 313
PHE A 317
 TYM  A 501 (-3.8A)
TYM  A 501 (-3.6A)
TYM  A 501 (-3.6A)
TYM  A 501 (-4.0A)
TYM  A 501 ( 3.8A)
TYM  A 501 (-3.0A)
TYM  A 501 (-3.2A)
TYM  A 501 (-4.8A)
TYM  A 501 (-4.8A)
TYM  A 501 (-3.6A)
TYM  A 501 (-4.7A)
 0.33A 2dr2A-1r6uA:
56.8		 2dr2A-1r6uA:
97.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 7 ILE A 359
PHE A 340
ILE A 175
PHE A 406
 None
None
TYM  A 501 ( 4.5A)
None
 1.02A 2q6hA-1r6uA:
undetectable		 2q6hA-1r6uA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 7 ILE A 359
PHE A 340
ILE A 175
PHE A 406
 None
None
TYM  A 501 ( 4.5A)
None
 1.02A 2qb4A-1r6uA:
undetectable		 2qb4A-1r6uA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 8 THR A  92
GLN A 347
ASP A  83
SER A  94
 None
 1.25A 2xz5A-1r6uA:
undetectable
2xz5C-1r6uA:
undetectable		 2xz5A-1r6uA:
18.85
2xz5C-1r6uA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 6 GLN A 295
PHE A 293
PHE A 297
PHE A 468
 None
 1.13A 3ablP-1r6uA:
undetectable
3ablW-1r6uA:
undetectable		 3ablP-1r6uA:
17.83
3ablW-1r6uA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 6 GLN A 304
PHE A 187
LEU A 183
PHE A 179
 None
 1.12A 3ablP-1r6uA:
undetectable
3ablW-1r6uA:
undetectable		 3ablP-1r6uA:
17.83
3ablW-1r6uA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 LEU A 403
ILE A 435
GLU A 436
ALA A 433
PHE A 406
 None
 1.21A 3axtA-1r6uA:
undetectable		 3axtA-1r6uA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 7 VAL A 216
LYS A 220
ILE A 223
GLY A 226
 None
 0.75A 3bjwB-1r6uA:
undetectable		 3bjwB-1r6uA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_C_TPFC490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 9 TYR A 248
MET A 241
PHE A 247
ALA A 286
ALA A 282
 None
 1.45A 3l4dC-1r6uA:
undetectable		 3l4dC-1r6uA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 5 ASP A 312
ILE A 175
PRO A 176
PHE A 177
 TYM  A 501 (-3.2A)
TYM  A 501 ( 4.5A)
TYM  A 501 (-4.4A)
None
 1.24A 3s3vA-1r6uA:
undetectable		 3s3vA-1r6uA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 PHE A 247
PHE A 293
VAL A 251
ASP A 237
ASP A 198
 None
 1.45A 4c9wA-1r6uA:
0.0		 4c9wA-1r6uA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 TYR A 100
VAL A  90
PHE A 339
GLY A  97
ASP A  86
 None
 1.33A 4mm4A-1r6uA:
undetectable		 4mm4A-1r6uA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM7_A_29JA603_1
(TRANSPORTER)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 10 TYR A 100
VAL A  90
PHE A 339
GLY A  97
ASP A  86
 None
 1.36A 4mm7A-1r6uA:
0.1		 4mm7A-1r6uA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 6 GLN A 304
PHE A 187
LEU A 183
PHE A 179
 None
 1.14A 5b1bC-1r6uA:
undetectable
5b1bJ-1r6uA:
undetectable		 5b1bC-1r6uA:
17.83
5b1bJ-1r6uA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		3 / 3 PHE A 339
ILE A 311
ASP A 101
 None
 0.74A 5cswA-1r6uA:
undetectable		 5cswA-1r6uA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		3 / 3 PHE A 339
ILE A 311
ASP A 101
 None
 0.75A 5cswB-1r6uA:
undetectable		 5cswB-1r6uA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 6 TYR A 316
GLY A 163
GLU A 199
ASP A 197
 None
TYM  A 501 (-3.6A)
TYM  A 501 (-3.0A)
None
 1.21A 5emlA-1r6uA:
undetectable		 5emlA-1r6uA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 GLY A 265
LEU A 103
PHE A 138
ILE A 136
PHE A  84
 None
 1.18A 5fsaB-1r6uA:
0.0		 5fsaB-1r6uA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 ASP A 397
HIS A 387
THR A 427
PHE A 400
GLY A 392
 None
 1.31A 5hfjB-1r6uA:
2.6		 5hfjB-1r6uA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 LEU A 158
MET A 143
VAL A 146
ILE A 120
THR A 124
 None
 1.32A 5w8aA-1r6uA:
0.0		 5w8aA-1r6uA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 6 GLN A 304
PHE A 187
LEU A 183
PHE A 179
 None
 1.07A 5z84P-1r6uA:
undetectable
5z84W-1r6uA:
0.0		 5z84P-1r6uA:
17.83
5z84W-1r6uA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 6 GLN A 295
PHE A 293
PHE A 297
PHE A 468
 None
 1.07A 5z85P-1r6uA:
undetectable
5z85W-1r6uA:
0.0		 5z85P-1r6uA:
17.83
5z85W-1r6uA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 6 GLN A 304
PHE A 187
LEU A 183
PHE A 179
 None
 1.10A 5z85P-1r6uA:
undetectable
5z85W-1r6uA:
0.0		 5z85P-1r6uA:
17.83
5z85W-1r6uA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 6 GLN A 304
PHE A 187
LEU A 183
PHE A 179
 None
 1.09A 5z86C-1r6uA:
undetectable
5z86J-1r6uA:
0.0		 5z86C-1r6uA:
17.83
5z86J-1r6uA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 6 GLN A 304
PHE A 187
LEU A 183
PHE A 179
 None
 1.07A 5z86P-1r6uA:
undetectable
5z86W-1r6uA:
0.0		 5z86P-1r6uA:
17.83
5z86W-1r6uA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 6 GLN A 295
PHE A 293
PHE A 297
PHE A 468
 None
 1.07A 5zcoP-1r6uA:
undetectable
5zcoW-1r6uA:
0.0		 5zcoP-1r6uA:
17.83
5zcoW-1r6uA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 6 GLN A 304
PHE A 187
LEU A 183
PHE A 179
 None
 1.02A 5zcoP-1r6uA:
undetectable
5zcoW-1r6uA:
0.0		 5zcoP-1r6uA:
17.83
5zcoW-1r6uA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 6 GLN A 304
PHE A 187
LEU A 183
PHE A 179
 None
 1.03A 5zcpC-1r6uA:
undetectable
5zcpJ-1r6uA:
0.0		 5zcpC-1r6uA:
17.83
5zcpJ-1r6uA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 6 GLN A 304
PHE A 187
LEU A 183
PHE A 179
 None
 1.08A 5zcpP-1r6uA:
undetectable
5zcpW-1r6uA:
0.0		 5zcpP-1r6uA:
17.83
5zcpW-1r6uA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		6 / 12 ILE A 193
GLY A 161
ASP A 197
ILE A 223
VAL A 457
ILE A 234
 None
TYM  A 501 (-3.6A)
None
None
None
None
 1.43A 6emuA-1r6uA:
undetectable		 6emuA-1r6uA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		4 / 8 VAL A 398
TYR A 402
HIS A 375
ASN A 373
 None
 1.29A 6gneB-1r6uA:
2.3		 6gneB-1r6uA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens) 		5 / 12 PHE A 339
GLY A  97
GLY A 345
ASP A  99
VAL A 398
 None
 1.06A 6mhtA-1r6uA:
undetectable		 6mhtA-1r6uA:
21.56