SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r6v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		5 / 10 GLY A 268
HIS A 267
ALA A 167
HIS A 295
ILE A 165
 None
 1.40A 1gtnN-1r6vA:
3.0
1gtnO-1r6vA:
3.1		 1gtnN-1r6vA:
7.60
1gtnO-1r6vA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H1D_A_SAMA301_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		5 / 12 GLY A 320
TYR A 318
TYR A 487
MET A 299
HIS A 500
 None
 1.40A 1h1dA-1r6vA:
undetectable		 1h1dA-1r6vA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		6 / 11 LEU A  43
ASP A 255
GLY A 253
GLY A 260
ILE A 261
VAL A  72
 None
 1.44A 1hxwB-1r6vA:
undetectable		 1hxwB-1r6vA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		5 / 8 THR A 463
GLY A 467
GLY A 611
SER A 610
GLY A  24
 None
 1.15A 1jhvA-1r6vA:
undetectable		 1jhvA-1r6vA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		5 / 9 THR A 463
GLY A 467
GLY A 611
SER A 610
GLY A  24
 None
 1.17A 1jhyA-1r6vA:
undetectable		 1jhyA-1r6vA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		3 / 3 ALA A 218
VAL A 228
TRP A 156
 None
 0.84A 1jnoA-1r6vA:
undetectable		 1jnoA-1r6vA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		3 / 3 ALA A 218
VAL A 228
TRP A 156
 None
 0.85A 1jnoB-1r6vA:
undetectable		 1jnoB-1r6vA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		3 / 3 ALA A 218
VAL A 228
TRP A 156
 None
 0.68A 1jo3A-1r6vA:
undetectable		 1jo3A-1r6vA:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		3 / 3 ALA A 218
VAL A 228
TRP A 156
 None
 0.68A 1jo3B-1r6vA:
undetectable		 1jo3B-1r6vA:
2.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		3 / 3 ALA A 218
VAL A 228
TRP A 156
 None
 0.87A 1jo4A-1r6vA:
undetectable		 1jo4A-1r6vA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		3 / 3 ALA A 218
VAL A 228
TRP A 156
 None
 0.87A 1jo4B-1r6vA:
undetectable		 1jo4B-1r6vA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		5 / 9 THR A 463
GLY A 467
GLY A 611
SER A 610
GLY A  24
 None
 1.17A 1l5kA-1r6vA:
undetectable		 1l5kA-1r6vA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		5 / 8 ILE A  89
ILE A  42
GLU A 101
VAL A  44
ILE A  55
 None
 1.40A 1linA-1r6vA:
undetectable		 1linA-1r6vA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		3 / 3 ALA A 218
VAL A 228
TRP A 156
 None
 0.94A 1magA-1r6vA:
undetectable		 1magA-1r6vA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		3 / 3 ALA A 218
VAL A 228
TRP A 156
 None
 0.94A 1magB-1r6vA:
undetectable		 1magB-1r6vA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		3 / 3 ALA A 218
VAL A 228
TRP A 156
 None
 0.80A 1ng8A-1r6vA:
undetectable		 1ng8A-1r6vA:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		3 / 3 ALA A 218
VAL A 228
TRP A 156
 None
 0.80A 1ng8B-1r6vA:
undetectable		 1ng8B-1r6vA:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		3 / 3 ALA A 218
VAL A 228
TRP A 156
 None
 0.89A 1nrmA-1r6vA:
undetectable		 1nrmA-1r6vA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		3 / 3 ALA A 218
VAL A 228
TRP A 156
 None
 0.89A 1nrmB-1r6vA:
undetectable		 1nrmB-1r6vA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		3 / 3 ALA A 218
VAL A 228
TRP A 156
 None
 0.87A 1nruA-1r6vA:
undetectable		 1nruA-1r6vA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		3 / 3 ALA A 218
VAL A 228
TRP A 156
 None
 0.87A 1nruB-1r6vA:
undetectable		 1nruB-1r6vA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		4 / 5 GLY A  24
GLN A 612
VAL A 471
SER A 610
 None
 1.47A 1p6kB-1r6vA:
0.0		 1p6kB-1r6vA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		5 / 12 TYR A 382
PRO A 375
ASP A 179
ILE A 225
LEU A 356
 None
None
CA  A   1 (-2.8A)
None
None
 1.09A 1r30A-1r6vA:
undetectable		 1r30A-1r6vA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		4 / 5 GLY A  24
GLN A 612
VAL A 471
SER A 610
 None
 1.43A 1rs6B-1r6vA:
0.0		 1rs6B-1r6vA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		4 / 5 GLY A  24
GLN A 612
VAL A 471
SER A 610
 None
 1.35A 1zzqB-1r6vA:
undetectable		 1zzqB-1r6vA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		4 / 5 GLY A  24
GLN A 612
VAL A 471
SER A 610
 None
 1.40A 1zzuA-1r6vA:
0.0		 1zzuA-1r6vA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		4 / 5 GLY A  24
GLN A 612
VAL A 471
SER A 610
 None
 1.47A 1zzuB-1r6vA:
undetectable		 1zzuB-1r6vA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		4 / 6 TYR A  37
ASP A  34
THR A  81
GLU A  39
 None
 1.03A 2dttB-1r6vA:
0.6
2dttC-1r6vA:
undetectable		 2dttB-1r6vA:
9.16
2dttC-1r6vA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		6 / 12 LEU A  43
ASP A 255
GLY A 253
GLY A 260
ILE A 261
VAL A  72
 None
 1.33A 2ienA-1r6vA:
undetectable		 2ienA-1r6vA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		6 / 12 LEU A  43
ASP A 255
GLY A 253
GLY A 260
ILE A 261
VAL A  72
 None
 1.37A 2ieoA-1r6vA:
undetectable		 2ieoA-1r6vA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		6 / 12 ILE A  27
ILE A  89
ALA A  85
THR A  81
ARG A  33
GLU A  31
 None
 1.48A 2j0dA-1r6vA:
undetectable		 2j0dA-1r6vA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		6 / 12 LEU A  43
ASP A 255
GLY A 253
GLY A 260
ILE A 261
VAL A  72
 None
 1.41A 2nnkB-1r6vA:
undetectable		 2nnkB-1r6vA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		6 / 12 GLY A 361
GLY A 209
GLY A 206
THR A 171
GLU A 368
VAL A 168
 None
 1.48A 2pxcA-1r6vA:
undetectable		 2pxcA-1r6vA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		6 / 12 LEU A  43
ASP A 255
GLY A 253
GLY A 260
ILE A 261
VAL A  72
 None
 1.39A 2q63A-1r6vA:
undetectable		 2q63A-1r6vA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		4 / 8 PHE A 339
ALA A 391
LEU A 327
ALA A 337
 None
 0.87A 2vcvF-1r6vA:
undetectable		 2vcvF-1r6vA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		4 / 7 PHE A 339
ALA A 391
LEU A 327
ALA A 337
 None
 0.86A 2vcvG-1r6vA:
undetectable		 2vcvG-1r6vA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		5 / 12 MET A 285
PRO A 315
ALA A 316
ALA A 259
MET A 293
 None
 1.20A 2x2nA-1r6vA:
undetectable		 2x2nA-1r6vA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		5 / 12 MET A 285
PRO A 315
ALA A 316
ALA A 259
MET A 293
 None
 1.18A 2x2nB-1r6vA:
undetectable		 2x2nB-1r6vA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		4 / 5 LEU A 577
GLN A 618
THR A 619
THR A 572
 None
 1.34A 2zj0B-1r6vA:
2.9		 2zj0B-1r6vA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		4 / 5 LEU A 577
GLN A 618
THR A 619
THR A 572
 None
 1.26A 2zj0C-1r6vA:
4.2		 2zj0C-1r6vA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		4 / 4 LEU A 577
GLN A 618
THR A 619
THR A 572
 None
 1.34A 2zj0D-1r6vA:
undetectable		 2zj0D-1r6vA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		5 / 12 GLY A 320
TYR A 318
TYR A 487
MET A 299
HIS A 500
 None
 1.41A 2zvjA-1r6vA:
2.0		 2zvjA-1r6vA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		4 / 5 LEU A 577
GLN A 618
THR A 619
THR A 572
 None
 1.29A 3ce6B-1r6vA:
3.0		 3ce6B-1r6vA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		3 / 3 LEU A  32
GLU A 101
ILE A  42
 None
 0.57A 3czhA-1r6vA:
undetectable		 3czhA-1r6vA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		4 / 7 VAL A  56
VAL A  64
ASN A  60
GLY A  61
 None
 1.12A 3kmoB-1r6vA:
undetectable		 3kmoB-1r6vA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		4 / 7 PHE A  29
ASP A  87
ILE A  42
VAL A  44
 None
 1.00A 3p6hA-1r6vA:
undetectable		 3p6hA-1r6vA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		6 / 12 LEU A  43
ASP A 255
GLY A 253
GLY A 260
ILE A 261
VAL A  72
 None
 1.35A 3tl9A-1r6vA:
undetectable		 3tl9A-1r6vA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		3 / 3 TYR A  46
GLU A 101
TYR A 283
 None
 0.73A 3ug8A-1r6vA:
1.9		 3ug8A-1r6vA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		4 / 6 ASP A 328
GLY A 352
VAL A 353
TRP A 144
 None
 0.94A 3vqrA-1r6vA:
undetectable		 3vqrA-1r6vA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		4 / 5 GLU A 107
GLY A 278
TYR A 251
ASP A 254
 None
 1.26A 3w9tD-1r6vA:
0.0		 3w9tD-1r6vA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		6 / 12 GLY A 361
GLY A 209
GLY A 206
THR A 171
GLU A 368
VAL A 168
 None
 1.47A 4ctkA-1r6vA:
undetectable		 4ctkA-1r6vA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		3 / 3 TYR A 436
ARG A 415
SER A 347
 None
 0.70A 4dr2I-1r6vA:
undetectable
4dr2J-1r6vA:
3.7		 4dr2I-1r6vA:
11.24
4dr2J-1r6vA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		4 / 7 PHE A 570
GLY A 644
THR A 653
LEU A 574
 None
 0.87A 4ejjD-1r6vA:
undetectable		 4ejjD-1r6vA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		3 / 3 GLN A 618
THR A 619
THR A 651
 None
 0.80A 4fu9A-1r6vA:
0.0		 4fu9A-1r6vA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		3 / 3 GLN A 618
THR A 619
THR A 651
 None
 0.80A 4fufA-1r6vA:
0.0		 4fufA-1r6vA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		4 / 8 ASN A 408
ALA A 409
PRO A 411
LEU A 449
 None
 0.96A 4jjkA-1r6vA:
2.3		 4jjkA-1r6vA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		4 / 7 GLY A 172
ASP A 170
GLY A 205
GLU A 368
 None
 0.93A 4koeA-1r6vA:
undetectable
4koeB-1r6vA:
3.5
4koeD-1r6vA:
undetectable		 4koeA-1r6vA:
21.93
4koeB-1r6vA:
21.93
4koeD-1r6vA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		5 / 9 THR A 463
GLY A 467
GLY A 611
SER A 610
GLY A  24
 None
 1.19A 4kqiA-1r6vA:
undetectable		 4kqiA-1r6vA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		3 / 3 TYR A 436
ARG A 415
SER A 347
 None
 0.75A 4lf7I-1r6vA:
undetectable
4lf7J-1r6vA:
3.5		 4lf7I-1r6vA:
11.24
4lf7J-1r6vA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		3 / 3 TYR A 436
ARG A 415
SER A 347
 None
 0.75A 4lf8I-1r6vA:
undetectable
4lf8J-1r6vA:
3.5		 4lf8I-1r6vA:
11.24
4lf8J-1r6vA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		4 / 5 ALA A 208
GLY A 206
ASP A 254
ASP A 170
 None
 0.96A 4n48A-1r6vA:
1.9		 4n48A-1r6vA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		3 / 3 SER A 202
ASP A 254
ASP A 170
 None
 0.81A 4uckA-1r6vA:
undetectable		 4uckA-1r6vA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		5 / 10 ALA A 376
ILE A 225
LEU A 356
LEU A 143
TYR A 382
 None
 1.13A 4xj7A-1r6vA:
3.1
4xj7B-1r6vA:
3.0		 4xj7A-1r6vA:
20.90
4xj7B-1r6vA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		4 / 7 GLY A 172
ASP A 170
GLY A 205
GLU A 368
 None
 0.81A 4z53A-1r6vA:
3.5
4z53B-1r6vA:
3.6		 4z53A-1r6vA:
22.33
4z53B-1r6vA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		5 / 8 LEU A 441
GLY A 150
ALA A 444
LEU A 402
GLY A 397
 None
 1.25A 4zauA-1r6vA:
undetectable		 4zauA-1r6vA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		6 / 12 GLY A 361
GLY A 209
GLY A 206
THR A 171
GLU A 368
VAL A 168
 None
 1.46A 5e9qA-1r6vA:
undetectable		 5e9qA-1r6vA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		6 / 12 GLY A 361
GLY A 209
GLY A 206
THR A 171
GLU A 368
VAL A 168
 None
 1.36A 5e9qC-1r6vA:
undetectable		 5e9qC-1r6vA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		5 / 11 ALA A 229
ALA A 232
VAL A 166
LEU A 402
VAL A 271
 None
 1.27A 5eb5A-1r6vA:
0.0		 5eb5A-1r6vA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		5 / 10 ALA A 229
ALA A 232
VAL A 166
LEU A 402
VAL A 271
 None
 1.26A 5eb5B-1r6vA:
undetectable		 5eb5B-1r6vA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		6 / 12 GLY A 361
GLY A 209
GLY A 206
THR A 171
GLU A 368
VAL A 168
 None
 1.47A 5ec8A-1r6vA:
undetectable		 5ec8A-1r6vA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		4 / 6 THR A 396
VAL A 399
VAL A 324
HIS A 394
 None
 0.86A 5eclD-1r6vA:
undetectable		 5eclD-1r6vA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		6 / 12 GLY A 361
GLY A 209
GLY A 206
THR A 171
GLU A 368
VAL A 168
 None
 1.46A 5eifA-1r6vA:
undetectable		 5eifA-1r6vA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		6 / 12 GLY A 361
GLY A 209
GLY A 206
THR A 171
GLU A 368
VAL A 168
 None
 1.43A 5eifC-1r6vA:
undetectable		 5eifC-1r6vA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		6 / 12 GLY A 361
GLY A 209
GLY A 206
THR A 171
GLU A 368
VAL A 168
 None
 1.46A 5eiwC-1r6vA:
undetectable		 5eiwC-1r6vA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		5 / 11 MET A 293
GLY A 454
VAL A 455
GLU A 456
ASP A 502
 None
 1.13A 5i3cC-1r6vA:
2.7		 5i3cC-1r6vA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		5 / 10 ALA A 519
ILE A 528
GLY A 659
PHE A 658
VAL A 672
 None
 1.08A 5i6xA-1r6vA:
undetectable		 5i6xA-1r6vA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		4 / 6 THR A 171
GLY A 209
TYR A 385
ILE A 355
 None
 0.83A 5kmfA-1r6vA:
undetectable
5kmfC-1r6vA:
0.0		 5kmfA-1r6vA:
17.82
5kmfC-1r6vA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		6 / 12 GLY A 361
GLY A 209
GLY A 206
THR A 171
GLU A 368
VAL A 168
 None
 1.49A 5kqrA-1r6vA:
undetectable		 5kqrA-1r6vA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		3 / 3 THR A 388
SER A 302
ASP A 170
 None
 0.65A 5kvaA-1r6vA:
2.9		 5kvaA-1r6vA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		3 / 3 THR A 388
SER A 302
ASP A 170
 None
 0.66A 5kvaB-1r6vA:
2.6		 5kvaB-1r6vA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		6 / 12 GLY A 361
GLY A 209
GLY A 206
THR A 171
GLU A 368
VAL A 168
 None
 1.50A 5m5bA-1r6vA:
undetectable		 5m5bA-1r6vA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		5 / 10 MET A 285
PHE A 289
ILE A 237
ALA A 264
ALA A 292
 None
 1.46A 5oy0b-1r6vA:
undetectable		 5oy0b-1r6vA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		4 / 5 GLY A  24
GLN A 612
VAL A 471
SER A 610
 None
 1.48A 5vunA-1r6vA:
undetectable		 5vunA-1r6vA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		5 / 8 THR A 200
GLY A 199
ALA A 198
GLY A 175
GLU A 181
 None
 1.47A 5vw9A-1r6vA:
undetectable		 5vw9A-1r6vA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		4 / 8 VAL A 359
HIS A 370
GLY A 224
LEU A 139
 None
None
CA  A   1 ( 4.4A)
None
 0.80A 5w3jB-1r6vA:
3.2		 5w3jB-1r6vA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		5 / 12 ILE A 629
ASN A 573
LEU A 621
PRO A 622
PRO A 580
 None
 1.12A 5xxiA-1r6vA:
undetectable		 5xxiA-1r6vA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		3 / 3 TYR A 532
PRO A 529
LEU A 536
 None
 0.84A 6beoA-1r6vA:
undetectable		 6beoA-1r6vA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		4 / 7 GLN A 452
GLY A 550
SER A 503
GLY A 504
 None
 0.78A 6ekzA-1r6vA:
0.0		 6ekzA-1r6vA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 1r6v SUBTILISIN-LIKE
SERINE PROTEASE
(Fervidobacterium
pennivorans) 		5 / 12 ILE A  55
VAL A  44
ILE A  42
PHE A  29
PRO A 472
 None
 1.02A 6hlpA-1r6vA:
4.0		 6hlpA-1r6vA:
21.35