SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r6z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Escherichia
coli;
Drosophila
melanogaster) 		4 / 6 VAL P   7
VAL P  49
ILE P  59
ASN P 266
 None
 0.91A 1e06A-1r6zP:
0.1		 1e06A-1r6zP:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Drosophila
melanogaster;
Escherichia
coli) 		3 / 3 GLU P 110
TRP P 229
LYS P 272
 MAL  P 727 (-2.8A)
MAL  P 727 ( 4.7A)
None
 1.21A 1qu2A-1r6zP:
undetectable		 1qu2A-1r6zP:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Escherichia
coli;
Drosophila
melanogaster) 		5 / 10 LEU P 191
LEU P 194
ILE P 160
GLU P 152
LEU P 150
 None
None
None
MAL  P 727 (-3.6A)
None
 1.24A 1wopA-1r6zP:
0.0		 1wopA-1r6zP:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Drosophila
melanogaster;
Escherichia
coli) 		4 / 5 LEU P 261
GLY P 288
ALA P 108
ILE P 107
 None
 0.84A 2aohB-1r6zP:
undetectable		 2aohB-1r6zP:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Escherichia
coli;
Drosophila
melanogaster) 		4 / 7 VAL P  96
ALA P 104
PHE P  91
PRO P  90
 None
 0.99A 2q6oA-1r6zP:
undetectable		 2q6oA-1r6zP:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Drosophila
melanogaster;
Escherichia
coli) 		4 / 6 PHE P 257
ALA P 161
LEU P 246
PRO P 158
 None
 0.97A 3bgdA-1r6zP:
undetectable		 3bgdA-1r6zP:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Drosophila
melanogaster;
Escherichia
coli) 		4 / 7 VAL P 109
GLY P 299
PRO P 228
LYS P 304
 None
 0.79A 3bjwC-1r6zP:
0.0		 3bjwC-1r6zP:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Escherichia
coli;
Drosophila
melanogaster) 		4 / 6 PRO P 125
LEU P 146
ALA P 222
PRO P 124
 None
 1.32A 3gv1A-1r6zP:
undetectable
3gv1C-1r6zP:
undetectable		 3gv1A-1r6zP:
14.99
3gv1C-1r6zP:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Escherichia
coli;
Drosophila
melanogaster) 		4 / 6 LEU P 146
ALA P 222
PRO P 124
PRO P 125
 None
 1.31A 3gv1A-1r6zP:
undetectable
3gv1B-1r6zP:
undetectable		 3gv1A-1r6zP:
14.99
3gv1B-1r6zP:
14.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Drosophila
melanogaster;
Escherichia
coli) 		10 / 12 ASP P  13
LYS P  14
LYS P  41
GLU P  43
GLU P  44
ALA P  62
ASP P  64
ARG P  65
GLU P 110
TRP P 229
 MAL  P 727 (-3.0A)
MAL  P 727 (-2.5A)
None
None
None
MAL  P 727 (-3.1A)
MAL  P 727 (-2.6A)
MAL  P 727 (-4.0A)
MAL  P 727 (-2.8A)
MAL  P 727 ( 4.7A)
 0.68A 3jyrA-1r6zP:
61.8		 3jyrA-1r6zP:
72.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Drosophila
melanogaster;
Escherichia
coli) 		10 / 12 ASP P  13
LYS P  14
LYS P  41
GLU P  43
GLU P  44
ALA P  62
ASP P  64
GLU P 110
PRO P 153
TRP P 229
 MAL  P 727 (-3.0A)
MAL  P 727 (-2.5A)
None
None
None
MAL  P 727 (-3.1A)
MAL  P 727 (-2.6A)
MAL  P 727 (-2.8A)
MAL  P 727 (-3.4A)
MAL  P 727 ( 4.7A)
 0.37A 3jyrA-1r6zP:
61.8		 3jyrA-1r6zP:
72.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Drosophila
melanogaster;
Escherichia
coli) 		6 / 7 ASN P  11
TRP P  61
GLU P 152
TYR P 154
MET P 329
TRP P 339
 MAL  P 727 (-4.4A)
MAL  P 727 (-4.3A)
MAL  P 727 (-3.6A)
MAL  P 727 (-3.7A)
MAL  P 727 ( 4.3A)
MAL  P 727 (-3.5A)
 0.31A 3jyrA-1r6zP:
61.8		 3jyrA-1r6zP:
72.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Escherichia
coli;
Drosophila
melanogaster) 		5 / 9 ILE P 131
LEU P 197
LYS P 255
ILE P 225
GLY P 190
 None
 1.32A 3sj4X-1r6zP:
undetectable		 3sj4X-1r6zP:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Drosophila
melanogaster;
Escherichia
coli) 		5 / 12 PHE P 155
GLY P 299
LEU P 298
GLU P 110
ALA P 230
 None
None
None
MAL  P 727 (-2.8A)
None
 0.86A 3tbgB-1r6zP:
0.0		 3tbgB-1r6zP:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Drosophila
melanogaster;
Escherichia
coli) 		5 / 12 PHE P 155
GLY P 299
LEU P 298
GLU P 110
ALA P 230
 None
None
None
MAL  P 727 (-2.8A)
None
 0.85A 3tbgD-1r6zP:
0.0		 3tbgD-1r6zP:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Drosophila
melanogaster;
Escherichia
coli) 		5 / 12 ALA P 230
TYR P  16
TYR P 209
ASN P 233
GLY P 227
 None
 1.35A 3vwqA-1r6zP:
0.0		 3vwqA-1r6zP:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Escherichia
coli;
Drosophila
melanogaster) 		4 / 8 ILE P 131
LEU P 197
ILE P 225
GLY P 190
 None
 0.88A 4hb6A-1r6zP:
undetectable		 4hb6A-1r6zP:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Drosophila
melanogaster;
Escherichia
coli) 		4 / 7 GLN P 252
THR P 127
THR P 319
MET P 320
 None
 1.10A 4mbsA-1r6zP:
undetectable		 4mbsA-1r6zP:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Escherichia
coli;
Drosophila
melanogaster) 		4 / 5 ASN P 266
ALA P  50
GLY P  55
ASP P  13
 None
None
None
MAL  P 727 (-3.0A)
 0.97A 4n48A-1r6zP:
undetectable		 4n48A-1r6zP:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Drosophila
melanogaster;
Escherichia
coli) 		5 / 9 ALA P 263
ALA P 104
LEU P 102
LEU P 261
VAL P 260
 None
 1.17A 4or0B-1r6zP:
undetectable		 4or0B-1r6zP:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Drosophila
melanogaster;
Escherichia
coli) 		4 / 6 GLU P 370
ASP P  64
ARG P  65
GLY P  68
 None
MAL  P 727 (-2.6A)
MAL  P 727 (-4.0A)
None
 0.86A 5cdnA-1r6zP:
undetectable
5cdnB-1r6zP:
undetectable		 5cdnA-1r6zP:
21.74
5cdnB-1r6zP:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Drosophila
melanogaster;
Escherichia
coli) 		5 / 12 LEU P 659
ASN P 622
THR P 620
ILE P 710
ILE P 617
 None
 1.05A 5itzB-1r6zP:
undetectable		 5itzB-1r6zP:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Drosophila
melanogaster;
Escherichia
coli) 		3 / 3 LYS P 614
LEU P 623
ILE P 605
 None
 0.82A 5kc4A-1r6zP:
undetectable		 5kc4A-1r6zP:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUO_D_PFLD402_1
(PROTON-GATED ION
CHANNEL)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Drosophila
melanogaster;
Escherichia
coli) 		5 / 9 SER P 597
SER P 601
SER P 714
ILE P 715
THR P 642
 None
 1.49A 5muoA-1r6zP:
0.0
5muoB-1r6zP:
undetectable
5muoC-1r6zP:
0.0
5muoD-1r6zP:
0.0
5muoE-1r6zP:
0.0		 5muoA-1r6zP:
10.17
5muoB-1r6zP:
10.17
5muoC-1r6zP:
10.17
5muoD-1r6zP:
10.17
5muoE-1r6zP:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Drosophila
melanogaster;
Escherichia
coli) 		6 / 12 ALA P 341
ALA P 337
GLY P 165
ALA P 187
PHE P 168
VAL P 180
 None
 1.40A 5w4zA-1r6zP:
0.2		 5w4zA-1r6zP:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Drosophila
melanogaster;
Escherichia
coli) 		6 / 12 ALA P 341
ALA P 337
GLY P 165
ALA P 187
PHE P 168
VAL P 180
 None
 1.42A 5w4zB-1r6zP:
undetectable		 5w4zB-1r6zP:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2
(Escherichia
coli;
Drosophila
melanogaster) 		4 / 6 SER P 702
GLU P 631
ARG P 628
ARG P 627
 None
 1.06A 5zw4A-1r6zP:
undetectable		 5zw4A-1r6zP:
17.42