SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r75'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 1r75 HYPOTHETICAL PROTEIN
(Leishmania
major) 		3 / 3 PHE A  47
TYR A  27
LEU A 102
 None
 0.66A 3keeB-1r75A:
undetectable		 3keeB-1r75A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1r75 HYPOTHETICAL PROTEIN
(Leishmania
major) 		3 / 3 PHE A  47
TYR A  27
LEU A 102
 None
 0.54A 3sueB-1r75A:
undetectable		 3sueB-1r75A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1r75 HYPOTHETICAL PROTEIN
(Leishmania
major) 		4 / 5 GLY A  17
ASP A  50
GLU A 103
VAL A  58
 None
 1.11A 4nkvD-1r75A:
0.0		 4nkvD-1r75A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 1r75 HYPOTHETICAL PROTEIN
(Leishmania
major) 		4 / 8 TYR A  35
PRO A  28
TYR A  27
THR A  26
 None
 0.97A 5mzrE-1r75A:
undetectable		 5mzrE-1r75A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 1r75 HYPOTHETICAL PROTEIN
(Leishmania
major) 		5 / 10 PRO A  70
ALA A  46
GLY A  23
THR A  24
ILE A  37
 None
 1.10A 5vyhA-1r75A:
undetectable		 5vyhA-1r75A:
17.60