SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r76'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		3 / 3 TRP A 376
ARG A 289
THR A 349
 None
 0.97A 1df7A-1r76A:
undetectable		 1df7A-1r76A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		3 / 3 TRP A 218
VAL A 221
TRP A 222
 None
 1.48A 1gmkC-1r76A:
undetectable
1gmkD-1r76A:
undetectable		 1gmkC-1r76A:
4.26
1gmkD-1r76A:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		5 / 11 GLY A  77
ARG A 135
LEU A  70
GLU A  73
PRO A 137
 None
 1.40A 1mjqA-1r76A:
undetectable
1mjqB-1r76A:
undetectable		 1mjqA-1r76A:
12.25
1mjqB-1r76A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		5 / 10 ARG A 135
LEU A  70
GLU A  73
PRO A 137
GLY A  77
 None
 1.39A 1mjqC-1r76A:
undetectable
1mjqD-1r76A:
undetectable		 1mjqC-1r76A:
12.25
1mjqD-1r76A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		5 / 10 GLY A  77
ARG A 135
LEU A  70
GLU A  73
PRO A 137
 None
 1.39A 1mjqG-1r76A:
undetectable
1mjqH-1r76A:
undetectable		 1mjqG-1r76A:
12.25
1mjqH-1r76A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		4 / 4 ILE A 179
LEU A 182
VAL A 186
ALA A 190
 None
 0.79A 1mz9A-1r76A:
undetectable		 1mz9A-1r76A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		4 / 5 ILE A 179
LEU A 182
VAL A 186
ALA A 190
 None
 0.84A 1mz9C-1r76A:
undetectable		 1mz9C-1r76A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		4 / 8 HIS A 109
THR A 177
PHE A 181
ASP A 131
 None
 0.99A 1p7lC-1r76A:
undetectable		 1p7lC-1r76A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		4 / 8 ASP A 230
PHE A 213
SER A  59
ALA A 298
 None
 1.11A 1rqpC-1r76A:
undetectable		 1rqpC-1r76A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		4 / 8 ASP A 230
PHE A 213
SER A  59
ALA A 298
 None
 1.08A 1rqpA-1r76A:
undetectable		 1rqpA-1r76A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		5 / 12 PRO A 311
ILE A 232
ALA A 313
PHE A 213
ALA A  33
 None
 1.16A 1sg9C-1r76A:
undetectable		 1sg9C-1r76A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		5 / 12 LEU A  36
ILE A 232
ALA A 298
LEU A  44
ARG A  49
 None
 1.04A 2fr3A-1r76A:
undetectable		 2fr3A-1r76A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		4 / 5 LEU A 202
ALA A 200
TRP A 124
LEU A 182
 None
 1.04A 2oaxA-1r76A:
undetectable		 2oaxA-1r76A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		4 / 8 ASP A 230
PHE A 213
SER A  59
ALA A 298
 None
 1.04A 2v7uA-1r76A:
undetectable		 2v7uA-1r76A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		4 / 6 LEU A 290
GLY A 342
LEU A 314
SER A 315
 None
 0.96A 3aiaA-1r76A:
undetectable		 3aiaA-1r76A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		4 / 6 PHE A 325
ILE A 275
ALA A 274
ALA A 267
 None
 1.01A 3mdrB-1r76A:
0.0		 3mdrB-1r76A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		3 / 3 LYS A 373
SER A 423
GLN A 419
 None
 1.20A 3si7A-1r76A:
undetectable		 3si7A-1r76A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_B_TEPB402_1
(PYRIDOXAL KINASE)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		4 / 5 SER A  69
HIS A 140
VAL A 167
ASP A  66
 None
 1.44A 4eohB-1r76A:
undetectable		 4eohB-1r76A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		5 / 10 SER A 211
ALA A 238
LEU A 239
GLY A 217
ALA A 424
 None
 1.41A 4fe1A-1r76A:
0.0
4fe1J-1r76A:
0.0		 4fe1A-1r76A:
20.29
4fe1J-1r76A:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		3 / 3 TRP A 376
GLN A 285
THR A 349
 None
 1.02A 4m2xA-1r76A:
undetectable		 4m2xA-1r76A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		5 / 11 GLY A 252
ALA A 251
THR A 265
ILE A 263
THR A 271
 None
 0.97A 4qgiA-1r76A:
undetectable		 4qgiA-1r76A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		4 / 6 PHE A 379
ALA A 312
HIS A 296
LEU A 314
 None
 1.24A 5dzkB-1r76A:
undetectable
5dzkP-1r76A:
undetectable		 5dzkB-1r76A:
21.20
5dzkP-1r76A:
0.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		4 / 6 PHE A 379
ALA A 312
HIS A 296
LEU A 314
 None
 1.23A 5dzkg-1r76A:
undetectable
5dzku-1r76A:
undetectable		 5dzkg-1r76A:
21.20
5dzku-1r76A:
0.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		4 / 5 TYR A 207
TRP A 218
PRO A 219
LEU A  63
 None
 1.36A 5eshA-1r76A:
0.0		 5eshA-1r76A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		3 / 3 ARG A 162
PRO A  81
TYR A 141
 None
 0.61A 5tzoB-1r76A:
undetectable		 5tzoB-1r76A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_A_TRPA402_0
(TRYPTOPHAN--TRNA
LIGASE)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		5 / 9 GLY A 255
GLN A 184
ASP A 248
ILE A 249
VAL A 259
 None
 1.21A 5v0iA-1r76A:
undetectable		 5v0iA-1r76A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_B_TRPB402_0
(TRYPTOPHAN--TRNA
LIGASE)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		5 / 9 GLY A 255
GLN A 184
ASP A 248
ILE A 249
VAL A 259
 None
 1.20A 5v0iB-1r76A:
undetectable		 5v0iB-1r76A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		4 / 7 ARG A 162
THR A 119
PRO A 120
PRO A 223
 None
 1.01A 6a4iB-1r76A:
0.1		 6a4iB-1r76A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		5 / 11 GLY A 217
TRP A 218
TYR A  55
ASN A 215
LEU A 299
 None
None
None
HG  A4000 (-3.4A)
None
 1.47A 6cenA-1r76A:
undetectable		 6cenA-1r76A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1r76 PECTATE LYASE
(Niveispirillum
irakense) 		3 / 3 ASN A  30
PRO A 311
GLN A 294
 None
 0.93A 6jnhA-1r76A:
undetectable		 6jnhA-1r76A:
17.53