SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r88'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1r88 MPT51/MPB51 ANTIGEN
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  87
LEU A  64
GLY A  81
SER A  75
ALA A 284
 None
 1.14A 2br4A-1r88A:
undetectable		 2br4A-1r88A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1r88 MPT51/MPB51 ANTIGEN
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  87
LEU A  64
GLY A  81
SER A  75
ALA A 284
 None
 1.19A 2br4D-1r88A:
undetectable		 2br4D-1r88A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 1r88 MPT51/MPB51 ANTIGEN
(Mycobacterium
tuberculosis) 		4 / 7 ASN A 233
GLY A 276
TRP A 283
SER A 169
 None
 1.18A 2o5yH-1r88A:
undetectable
2o5yL-1r88A:
undetectable		 2o5yH-1r88A:
21.34
2o5yL-1r88A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 1r88 MPT51/MPB51 ANTIGEN
(Mycobacterium
tuberculosis) 		4 / 8 VAL A  62
GLY A 143
GLY A 150
ALA A 151
 None
 0.75A 3aruA-1r88A:
undetectable		 3aruA-1r88A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 1r88 MPT51/MPB51 ANTIGEN
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 100
ALA A  98
LEU A  65
PRO A  97
 None
 0.95A 3bgdA-1r88A:
undetectable		 3bgdA-1r88A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1r88 MPT51/MPB51 ANTIGEN
(Mycobacterium
tuberculosis) 		3 / 3 GLY A  89
ILE A 294
VAL A 295
 None
 0.51A 3nv6A-1r88A:
undetectable		 3nv6A-1r88A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 1r88 MPT51/MPB51 ANTIGEN
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 166
ALA A 216
LEU A 154
PHE A 162
LEU A 219
 None
 1.07A 3p2kC-1r88A:
2.1		 3p2kC-1r88A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1r88 MPT51/MPB51 ANTIGEN
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 153
ALA A 156
MET A 104
GLY A 147
GLY A 148
 None
 1.07A 4qwuK-1r88A:
undetectable
4qwuL-1r88A:
undetectable		 4qwuK-1r88A:
22.78
4qwuL-1r88A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1r88 MPT51/MPB51 ANTIGEN
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 153
ALA A 156
MET A 104
GLY A 147
GLY A 148
 None
 1.04A 4qwuY-1r88A:
undetectable
4qwuZ-1r88A:
undetectable		 4qwuY-1r88A:
22.78
4qwuZ-1r88A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1r88 MPT51/MPB51 ANTIGEN
(Mycobacterium
tuberculosis) 		5 / 12 SER A 103
PHE A 119
MET A  46
LEU A 120
LEU A  65
 None
 1.32A 4xumA-1r88A:
undetectable		 4xumA-1r88A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1r88 MPT51/MPB51 ANTIGEN
(Mycobacterium
tuberculosis) 		5 / 12 SER A  75
ALA A 101
TYR A 105
ALA A  70
GLY A  71
 None
 1.34A 5tzoA-1r88A:
undetectable		 5tzoA-1r88A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1r88 MPT51/MPB51 ANTIGEN
(Mycobacterium
tuberculosis) 		5 / 12 SER A  75
ALA A 101
TYR A 105
ALA A  70
GLY A  71
 None
 1.32A 5tzoC-1r88A:
undetectable		 5tzoC-1r88A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1r88 MPT51/MPB51 ANTIGEN
(Mycobacterium
tuberculosis) 		3 / 3 TYR A 149
HIS A 210
MET A 198
 None
 1.20A 6af6A-1r88A:
undetectable		 6af6A-1r88A:
23.22