SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r8g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		5 / 9 ALA A 147
ASP A 146
GLY A 153
VAL A 198
ILE A 148
 None
 1.14A 1hpvB-1r8gA:
undetectable		 1hpvB-1r8gA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		5 / 12 GLY A  98
VAL A 132
SER A 180
ASP A 242
ARG A 284
 None
 1.49A 1jdvE-1r8gA:
undetectable
1jdvF-1r8gA:
undetectable		 1jdvE-1r8gA:
20.51
1jdvF-1r8gA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		5 / 12 LEU A 314
ALA A 167
ALA A 345
ALA A 166
LEU A 307
 None
 1.34A 1rbpA-1r8gA:
undetectable		 1rbpA-1r8gA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		4 / 6 LEU A 314
TRP A 263
LEU A 264
PHE A 270
 None
 1.26A 1ru9H-1r8gA:
undetectable
1ru9L-1r8gA:
undetectable		 1ru9H-1r8gA:
20.32
1ru9L-1r8gA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		4 / 6 LEU A 314
TRP A 263
LEU A 264
PHE A 270
 None
 1.27A 1rukH-1r8gA:
undetectable
1rukL-1r8gA:
undetectable		 1rukH-1r8gA:
20.32
1rukL-1r8gA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		4 / 8 LEU A 211
LEU A 223
ASP A 222
ASP A 218
 None
 0.91A 2j2pA-1r8gA:
undetectable
2j2pB-1r8gA:
undetectable		 2j2pA-1r8gA:
21.85
2j2pB-1r8gA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		3 / 3 LEU A   3
PRO A   4
ARG A 228
 None
 0.59A 2qd4B-1r8gA:
undetectable		 2qd4B-1r8gA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		3 / 3 LEU A   3
PRO A   4
ARG A 228
 None
 0.59A 2qd5A-1r8gA:
undetectable		 2qd5A-1r8gA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		3 / 3 TYR A 170
VAL A 352
THR A 174
 None
 0.82A 2ygnA-1r8gA:
undetectable		 2ygnA-1r8gA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		5 / 10 ALA A 287
LEU A 292
LEU A 307
MET A 253
HIS A 249
 None
 1.30A 3erdB-1r8gA:
0.0		 3erdB-1r8gA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		5 / 12 VAL A 139
GLY A 140
ILE A 325
ARG A  67
LEU A 264
 None
 1.15A 3ijdB-1r8gA:
0.0		 3ijdB-1r8gA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		5 / 12 PHE A 157
VAL A 158
PRO A 229
ILE A 257
VAL A 238
 None
 1.25A 3iw1A-1r8gA:
undetectable		 3iw1A-1r8gA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		5 / 10 LEU A  14
ALA A 261
VAL A 236
VAL A 137
VAL A 139
 None
 1.12A 3nu9B-1r8gA:
undetectable		 3nu9B-1r8gA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		4 / 5 HIS A  52
SER A  34
SER A  57
VAL A  22
 None
 1.35A 4a99D-1r8gA:
undetectable		 4a99D-1r8gA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		3 / 3 ARG A 182
TYR A 290
ASN A 343
 None
 0.72A 4ffwB-1r8gA:
undetectable		 4ffwB-1r8gA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		5 / 12 ILE A 296
GLY A 291
GLY A 294
ILE A 162
ALA A 166
 None
 1.11A 4kicB-1r8gA:
undetectable		 4kicB-1r8gA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		4 / 8 HIS A 300
PRO A 299
ASP A 298
ASP A 276
 None
 1.21A 4kttA-1r8gA:
undetectable		 4kttA-1r8gA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		4 / 8 HIS A 300
PRO A 299
ASP A 298
ASP A 276
 None
 1.20A 4kttC-1r8gA:
undetectable		 4kttC-1r8gA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		5 / 8 ALA A 147
ASP A 146
GLY A 153
VAL A 198
ILE A 148
 None
 1.23A 4ll3A-1r8gA:
undetectable		 4ll3A-1r8gA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		5 / 9 ALA A 147
ASP A 146
GLY A 153
VAL A 198
ILE A 148
 None
 1.23A 4ll3B-1r8gA:
undetectable		 4ll3B-1r8gA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		4 / 8 HIS A 300
PRO A 299
ASP A 298
ASP A 276
 None
 1.23A 4ndnA-1r8gA:
undetectable		 4ndnA-1r8gA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		4 / 7 HIS A 300
PRO A 299
ASP A 298
ASP A 276
 None
 1.25A 4ndnC-1r8gA:
undetectable		 4ndnC-1r8gA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		4 / 7 HIS A 300
PRO A 299
ASP A 298
ASP A 276
 None
 1.29A 4odjA-1r8gA:
undetectable		 4odjA-1r8gA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		4 / 8 ILE A 318
PHE A 161
LEU A 314
LEU A 154
 None
 0.89A 4qopC-1r8gA:
undetectable		 4qopC-1r8gA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		5 / 11 ALA A 287
LEU A 292
LEU A 307
MET A 253
HIS A 249
 None
 1.31A 4zn7B-1r8gA:
undetectable		 4zn7B-1r8gA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		4 / 7 HIS A 300
PRO A 299
ASP A 298
ASP A 276
 None
 1.24A 5a1iA-1r8gA:
undetectable		 5a1iA-1r8gA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		3 / 3 GLU A 237
HIS A 136
ASP A 226
 None
 0.76A 5c0oG-1r8gA:
undetectable		 5c0oG-1r8gA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		4 / 6 CYH A 141
LEU A 150
HIS A 262
LEU A 265
 None
 1.07A 5hpuC-1r8gA:
undetectable
5hpuD-1r8gA:
undetectable		 5hpuC-1r8gA:
6.30
5hpuD-1r8gA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		4 / 7 GLY A 134
PHE A 133
GLU A  19
ASP A 242
 None
 1.02A 5n5dB-1r8gA:
undetectable		 5n5dB-1r8gA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		5 / 7 LEU A 164
GLY A 341
SER A 165
LEU A 307
THR A 308
 None
 1.41A 5o96C-1r8gA:
undetectable		 5o96C-1r8gA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		5 / 7 LEU A 164
ILE A  16
GLY A  15
LEU A  14
ILE A 331
 None
 0.84A 5vkqA-1r8gA:
undetectable
5vkqB-1r8gA:
undetectable		 5vkqA-1r8gA:
13.06
5vkqB-1r8gA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		5 / 8 LEU A 164
ILE A  16
GLY A  15
LEU A  14
ILE A 331
 None
 0.85A 5vkqB-1r8gA:
undetectable
5vkqC-1r8gA:
undetectable		 5vkqB-1r8gA:
13.06
5vkqC-1r8gA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		5 / 9 LEU A 164
ILE A  16
GLY A  15
LEU A  14
ILE A 331
 None
 0.79A 5vkqC-1r8gA:
undetectable
5vkqD-1r8gA:
undetectable		 5vkqC-1r8gA:
13.06
5vkqD-1r8gA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		5 / 12 LEU A 164
ALA A 259
ILE A 331
ALA A 330
ILE A 318
 None
 1.26A 5xiwD-1r8gA:
undetectable		 5xiwD-1r8gA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		3 / 3 VAL A 238
GLU A 237
ILE A 257
 None
 0.52A 6f7lB-1r8gA:
undetectable		 6f7lB-1r8gA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1r8g HYPOTHETICAL PROTEIN
YBDK
(Escherichia
coli) 		4 / 7 HIS A 300
PRO A 299
ASP A 298
ASP A 276
 None
 1.24A 6g6rA-1r8gA:
undetectable		 6g6rA-1r8gA:
24.14