SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r8o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1r8o KUNITZ TRYPSIN
INHIBITOR
KUNITZ TRYPSIN
INHIBITOR
(Copaifera
langsdorffii;
Copaifera
langsdorffii) 		4 / 5 VAL B 152
SER A  43
VAL A  45
SER B 101
 None
 0.92A 2j9cA-1r8oB:
undetectable
2j9cB-1r8oB:
undetectable
2j9cC-1r8oB:
undetectable		 2j9cA-1r8oB:
28.21
2j9cB-1r8oB:
28.21
2j9cC-1r8oB:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1r8o KUNITZ TRYPSIN
INHIBITOR
KUNITZ TRYPSIN
INHIBITOR
(Copaifera
langsdorffii;
Copaifera
langsdorffii) 		4 / 7 SER B 101
LYS A  94
VAL B 152
SER A  43
 None
 1.02A 2j9cA-1r8oB:
undetectable
2j9cB-1r8oB:
undetectable
2j9cC-1r8oB:
undetectable		 2j9cA-1r8oB:
28.21
2j9cB-1r8oB:
28.21
2j9cC-1r8oB:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 1r8o KUNITZ TRYPSIN
INHIBITOR
(Copaifera
langsdorffii) 		5 / 12 ASP B 127
ASP B 139
VAL A  31
VAL B 143
ILE B 141
 None
 0.82A 2o4lA-1r8oB:
undetectable		 2o4lA-1r8oB:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 1r8o KUNITZ TRYPSIN
INHIBITOR
KUNITZ TRYPSIN
INHIBITOR
(Copaifera
langsdorffii;
Copaifera
langsdorffii) 		4 / 6 LEU B 151
VAL A  44
VAL A  57
VAL A  78
 None
 0.91A 2z97A-1r8oB:
undetectable		 2z97A-1r8oB:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 1r8o KUNITZ TRYPSIN
INHIBITOR
(Copaifera
langsdorffii) 		5 / 12 ASP B 127
ASP B 139
VAL A  31
VAL B 143
ILE B 141
 None
 0.91A 3cyxA-1r8oB:
undetectable		 3cyxA-1r8oB:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 1r8o KUNITZ TRYPSIN
INHIBITOR
KUNITZ TRYPSIN
INHIBITOR
(Copaifera
langsdorffii;
Copaifera
langsdorffii) 		5 / 12 TYR B 129
GLY A  75
GLY B 114
SER A  62
ASP A  13
 None
 1.14A 3dlcA-1r8oB:
undetectable		 3dlcA-1r8oB:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1r8o KUNITZ TRYPSIN
INHIBITOR
(Copaifera
langsdorffii) 		4 / 8 GLU A  77
SER A  89
VAL B 104
TRP A  91
 None
 1.36A 4v3yA-1r8oA:
undetectable
4v3yB-1r8oA:
undetectable		 4v3yA-1r8oA:
12.62
4v3yB-1r8oA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1r8o KUNITZ TRYPSIN
INHIBITOR
(Copaifera
langsdorffii) 		3 / 3 LEU A  32
ALA A  33
LEU A  55
 None
 0.55A 5uunB-1r8oA:
undetectable		 5uunB-1r8oA:
16.73