SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r8w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 8 GLU A 202
LEU A  49
ALA A  52
LEU A  53
 None
 0.72A 1hwiD-1r8wA:
0.0		 1hwiD-1r8wA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 9 SER A 661
GLY A 653
ARG A 455
LEU A 651
GLY A 649
 None
 0.99A 1jb0A-1r8wA:
undetectable		 1jb0A-1r8wA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 12 GLN A 549
VAL A 551
ALA A 762
ILE A 775
HIS A 332
 None
 1.09A 1kxhA-1r8wA:
2.7		 1kxhA-1r8wA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 12 VAL A 551
GLY A 550
ALA A 762
ILE A 775
HIS A 332
 None
 1.24A 1kxhA-1r8wA:
2.7		 1kxhA-1r8wA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 12 LEU A 665
THR A 460
TYR A 491
MET A 488
PHE A 484
 None
 1.14A 1mx8A-1r8wA:
undetectable		 1mx8A-1r8wA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		3 / 3 ARG A 659
ASP A 466
ASN A 468
 None
 0.83A 1nbhA-1r8wA:
undetectable		 1nbhA-1r8wA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		3 / 3 ARG A 659
ASP A 466
ASN A 468
 None
 0.82A 1nbhD-1r8wA:
undetectable		 1nbhD-1r8wA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 4 GLY A 163
VAL A 165
TRP A 445
GLY A 444
 None
 1.46A 1ng8A-1r8wA:
undetectable		 1ng8A-1r8wA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 4 GLY A 163
VAL A 165
TRP A 445
GLY A 444
 None
 1.45A 1ng8B-1r8wA:
undetectable		 1ng8B-1r8wA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 12 LEU A 719
LEU A 716
GLY A 715
GLN A 703
THR A 681
 None
 1.07A 1p93A-1r8wA:
undetectable		 1p93A-1r8wA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		3 / 3 ARG A  31
VAL A 122
TRP A 126
 None
 1.17A 1qw6A-1r8wA:
undetectable		 1qw6A-1r8wA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		3 / 3 ARG A  31
VAL A 122
TRP A 126
 None
 1.21A 1qwcA-1r8wA:
undetectable		 1qwcA-1r8wA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 12 ILE A  48
GLY A 533
GLY A 540
SER A 523
LEU A 205
 None
 0.98A 1rjdA-1r8wA:
undetectable		 1rjdA-1r8wA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 12 ILE A  48
GLY A 533
GLY A 540
SER A 523
LEU A 205
 None
 0.96A 1rjdB-1r8wA:
undetectable		 1rjdB-1r8wA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 12 ILE A  48
GLY A 533
GLY A 540
SER A 523
LEU A 205
 None
 0.95A 1rjdC-1r8wA:
undetectable		 1rjdC-1r8wA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 12 LEU A 639
ALA A 695
ILE A 694
ILE A 556
LEU A 453
 None
 1.13A 1tw4A-1r8wA:
0.0		 1tw4A-1r8wA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		3 / 3 ARG A  31
VAL A 122
TRP A 126
 None
 1.15A 1vagA-1r8wA:
2.0		 1vagA-1r8wA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 4 GLY A 334
SER A 642
VAL A 646
LEU A 771
 None
 1.32A 1yajB-1r8wA:
undetectable		 1yajB-1r8wA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		3 / 3 ARG A  31
VAL A 122
TRP A 126
 None
 1.16A 1zviA-1r8wA:
1.8		 1zviA-1r8wA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 12 LEU A 639
ALA A 695
ILE A 694
ILE A 556
LEU A 453
 None
 1.13A 2jn3A-1r8wA:
undetectable		 2jn3A-1r8wA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 6 PRO A 285
ASP A 527
ASP A 168
TYR A 169
 None
 1.45A 2lh8A-1r8wA:
0.0		 2lh8A-1r8wA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 12 SER A 523
ASN A 544
ALA A 517
THR A 131
VAL A 162
 None
 1.29A 2nniA-1r8wA:
0.0		 2nniA-1r8wA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 8 ILE A 321
TYR A 222
ASP A 320
ARG A  67
 None
 1.04A 2v57A-1r8wA:
0.4		 2v57A-1r8wA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 8 ILE A 321
TYR A 222
ASP A 320
ARG A  67
 None
 1.04A 2v57C-1r8wA:
0.3		 2v57C-1r8wA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 12 VAL A 563
GLN A 494
ILE A 461
SER A 463
PHE A 487
 None
 1.44A 2vdyA-1r8wA:
undetectable		 2vdyA-1r8wA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 8 LEU A 519
ILE A  35
PHE A  39
PHE A  89
 None
 0.94A 2weyB-1r8wA:
2.4		 2weyB-1r8wA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 6 LEU A 242
ILE A  66
ILE A 273
LEU A 266
 None
 0.95A 2xkwB-1r8wA:
undetectable		 2xkwB-1r8wA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 7 TYR A 428
VAL A 434
TYR A 406
ILE A 431
 None
 1.24A 2xz5B-1r8wA:
undetectable
2xz5E-1r8wA:
0.0		 2xz5B-1r8wA:
14.66
2xz5E-1r8wA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 8 ILE A 431
TYR A 428
VAL A 434
TYR A 406
 None
 1.27A 2xz5A-1r8wA:
undetectable
2xz5C-1r8wA:
undetectable		 2xz5A-1r8wA:
14.66
2xz5C-1r8wA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 8 ILE A 431
TYR A 428
VAL A 434
TYR A 406
 None
 1.25A 2xz5C-1r8wA:
undetectable
2xz5D-1r8wA:
undetectable		 2xz5C-1r8wA:
14.66
2xz5D-1r8wA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 7 ILE A 431
TYR A 428
VAL A 434
TYR A 406
 None
 1.25A 2xz5D-1r8wA:
undetectable
2xz5E-1r8wA:
undetectable		 2xz5D-1r8wA:
14.66
2xz5E-1r8wA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 12 ARG A 325
MET A 338
GLY A 432
SER A 284
GLY A 161
 None
 1.47A 2y6rC-1r8wA:
undetectable		 2y6rC-1r8wA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 6 GLN A 549
GLY A 638
HIS A 164
CYH A 433
 None
 1.41A 3ai8B-1r8wA:
0.0		 3ai8B-1r8wA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 10 VAL A 344
ALA A 354
ILE A 411
ILE A 343
THR A 355
 None
 1.22A 3clbD-1r8wA:
2.1		 3clbD-1r8wA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 7 ILE A 775
PHE A 450
PHE A 333
GLY A 106
 None
 1.04A 3em0B-1r8wA:
0.0		 3em0B-1r8wA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 10 VAL A 344
ALA A 354
ILE A 411
ILE A 343
THR A 355
 None
 1.22A 3hbbD-1r8wA:
2.6		 3hbbD-1r8wA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 8 GLY A 163
PHE A 269
PHE A 177
PHE A 521
 None
 0.99A 3ko0D-1r8wA:
0.2
3ko0E-1r8wA:
0.2		 3ko0D-1r8wA:
9.70
3ko0E-1r8wA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 8 GLY A 280
PHE A 269
PHE A 177
PHE A 521
 None
 0.84A 3ko0D-1r8wA:
0.2
3ko0E-1r8wA:
0.2		 3ko0D-1r8wA:
9.70
3ko0E-1r8wA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 7 GLY A 163
PHE A 269
PHE A 177
PHE A 521
 None
 1.07A 3ko0L-1r8wA:
0.2
3ko0N-1r8wA:
0.2		 3ko0L-1r8wA:
9.70
3ko0N-1r8wA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 7 GLY A 280
PHE A 269
PHE A 177
PHE A 521
 None
 0.84A 3ko0L-1r8wA:
0.2
3ko0N-1r8wA:
0.2		 3ko0L-1r8wA:
9.70
3ko0N-1r8wA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 7 PHE A 521
GLY A 163
PHE A 269
PHE A 177
 None
 1.11A 3ko0K-1r8wA:
0.3
3ko0S-1r8wA:
0.2		 3ko0K-1r8wA:
9.70
3ko0S-1r8wA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 7 PHE A 521
GLY A 280
PHE A 269
PHE A 177
 None
 1.00A 3ko0K-1r8wA:
0.3
3ko0S-1r8wA:
0.2		 3ko0K-1r8wA:
9.70
3ko0S-1r8wA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 7 PHE A 521
GLY A 163
PHE A 269
PHE A 177
 None
 1.12A 3ko0R-1r8wA:
0.3
3ko0T-1r8wA:
0.2		 3ko0R-1r8wA:
9.70
3ko0T-1r8wA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 7 PHE A 521
GLY A 280
PHE A 269
PHE A 177
 None
 0.93A 3ko0R-1r8wA:
0.3
3ko0T-1r8wA:
0.2		 3ko0R-1r8wA:
9.70
3ko0T-1r8wA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		3 / 3 GLU A  37
GLU A  60
ASN A  61
 None
 0.73A 3lp9B-1r8wA:
0.0
3lp9D-1r8wA:
undetectable		 3lp9B-1r8wA:
14.29
3lp9D-1r8wA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 7 ILE A 644
LEU A 453
THR A 699
THR A 655
 None
 0.98A 3nxuA-1r8wA:
0.0		 3nxuA-1r8wA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 9 SER A 661
GLY A 653
ARG A 455
LEU A 651
GLY A 649
 None
 1.00A 3pcqA-1r8wA:
undetectable		 3pcqA-1r8wA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		3 / 3 LEU A 745
ARG A 673
ASN A 737
 None
 0.74A 3qxvD-1r8wA:
undetectable		 3qxvD-1r8wA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 7 ILE A  20
LEU A  21
SER A 770
VAL A 761
 None
 0.98A 3r9vA-1r8wA:
undetectable
3r9vB-1r8wA:
undetectable		 3r9vA-1r8wA:
17.99
3r9vB-1r8wA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 5 ASP A 408
SER A 377
VAL A 378
GLY A 346
 None
 1.03A 3rxhA-1r8wA:
undetectable		 3rxhA-1r8wA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_C_1KXC277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 10 TYR A 218
ILE A 216
VAL A 219
TYR A 222
SER A 253
 None
 1.47A 3uprC-1r8wA:
undetectable		 3uprC-1r8wA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 11 ARG A 325
MET A 338
GLY A 432
SER A 284
GLY A 161
 None
 1.46A 4a6nC-1r8wA:
0.0		 4a6nC-1r8wA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 7 SER A 282
TYR A 157
HIS A 446
HIS A 164
 None
 1.38A 4arcA-1r8wA:
2.8		 4arcA-1r8wA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 12 VAL A 563
GLN A 494
ILE A 461
SER A 463
PHE A 487
 None
 1.48A 4c49B-1r8wA:
undetectable		 4c49B-1r8wA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 12 VAL A 563
GLN A 494
ILE A 461
SER A 463
PHE A 487
 None
 1.46A 4c49C-1r8wA:
undetectable		 4c49C-1r8wA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 12 SER A 524
GLU A 183
ILE A 180
TYR A 295
ALA A 257
 None
 1.09A 4foxD-1r8wA:
0.0		 4foxD-1r8wA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 11 SER A 661
GLY A 653
ARG A 455
LEU A 651
GLY A 649
 None
 0.95A 4kt0A-1r8wA:
0.0
4kt0J-1r8wA:
undetectable		 4kt0A-1r8wA:
21.64
4kt0J-1r8wA:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 11 SER A 661
GLY A 653
ARG A 455
LEU A 651
GLY A 649
 None
 0.99A 4l6v1-1r8wA:
undetectable
4l6v6-1r8wA:
2.1		 4l6v1-1r8wA:
21.64
4l6v6-1r8wA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		3 / 3 HIS A 513
VAL A 526
LEU A 522
 None
 0.76A 4m2vA-1r8wA:
undetectable		 4m2vA-1r8wA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 12 GLY A 658
ASN A 584
PHE A 586
SER A 589
ILE A 592
 None
 1.15A 4pb1A-1r8wA:
undetectable		 4pb1A-1r8wA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 12 GLY A 658
ASN A 584
PHE A 586
SER A 589
ILE A 592
 None
 1.21A 4pd5A-1r8wA:
undetectable		 4pd5A-1r8wA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 12 LEU A 578
VAL A 563
PRO A 656
THR A 655
GLY A 649
 None
 1.24A 4q15A-1r8wA:
undetectable		 4q15A-1r8wA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 12 LEU A 578
VAL A 563
PRO A 656
THR A 655
GLY A 649
 None
 1.23A 4q15B-1r8wA:
undetectable		 4q15B-1r8wA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 8 THR A 136
GLY A 155
VAL A 154
ASP A 506
 None
 0.73A 4qvvK-1r8wA:
undetectable
4qvvL-1r8wA:
undetectable		 4qvvK-1r8wA:
13.78
4qvvL-1r8wA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 8 THR A 136
GLY A 155
VAL A 154
ASP A 506
 None
 0.73A 4qvvY-1r8wA:
undetectable
4qvvZ-1r8wA:
undetectable		 4qvvY-1r8wA:
13.78
4qvvZ-1r8wA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 4 GLY A 254
VAL A 219
PHE A 267
ILE A 270
 None
 1.17A 4xv2B-1r8wA:
undetectable		 4xv2B-1r8wA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJQ_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 11 SER A 282
LEU A 665
ASN A 697
GLU A 435
GLY A 763
 None
 1.43A 4zjqA-1r8wA:
0.0		 4zjqA-1r8wA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		3 / 3 TYR A 543
LYS A 438
LYS A 441
 None
 1.10A 5dbyA-1r8wA:
0.0		 5dbyA-1r8wA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 9 HIS A 281
GLY A 161
GLY A 280
ASP A 447
HIS A 164
 None
 1.44A 5f8yA-1r8wA:
0.0		 5f8yA-1r8wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 8 HIS A 281
GLY A 161
GLY A 280
ASP A 447
HIS A 164
 None
 1.49A 5f8yA-1r8wA:
0.0		 5f8yA-1r8wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 9 HIS A 281
GLY A 161
GLY A 280
ASP A 447
HIS A 164
 None
 1.49A 5f8yA-1r8wA:
0.0		 5f8yA-1r8wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 9 HIS A 281
GLY A 161
GLY A 280
ASP A 447
HIS A 164
 None
 1.46A 5f8yB-1r8wA:
undetectable		 5f8yB-1r8wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 7 ASN A 356
VAL A 358
SER A 359
ALA A 362
 None
 0.84A 5fpdA-1r8wA:
3.0		 5fpdA-1r8wA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 7 ASN A 356
VAL A 358
SER A 359
ALA A 362
 None
 0.84A 5fpdB-1r8wA:
2.6		 5fpdB-1r8wA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		3 / 3 ARG A  31
VAL A 122
TRP A 126
 None
 1.24A 5fvoA-1r8wA:
undetectable		 5fvoA-1r8wA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		3 / 3 ASN A 718
SER A 721
SER A 720
 None
 0.79A 5gsnA-1r8wA:
undetectable		 5gsnA-1r8wA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 10 ASP A 447
TYR A 157
GLY A 638
GLY A 444
VAL A 624
 None
 1.15A 5i6xA-1r8wA:
undetectable		 5i6xA-1r8wA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		3 / 3 LYS A 317
LEU A 342
ILE A 311
 None
 0.71A 5kc0A-1r8wA:
undetectable		 5kc0A-1r8wA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 9 SER A 661
GLY A 653
ARG A 455
LEU A 651
GLY A 649
 None
 0.94A 5l8rA-1r8wA:
undetectable		 5l8rA-1r8wA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 7 THR A 396
PHE A 705
GLN A 703
MET A 787
 None
 0.96A 5u6mA-1r8wA:
2.4		 5u6mA-1r8wA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_B_SALB503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 7 THR A 396
PHE A 705
GLN A 703
MET A 787
 None
 1.13A 5u6mB-1r8wA:
undetectable		 5u6mB-1r8wA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 7 TRP A  93
ARG A 104
VAL A  27
SER A  83
 None
 1.32A 5umwA-1r8wA:
0.0
5umwF-1r8wA:
0.0		 5umwA-1r8wA:
7.29
5umwF-1r8wA:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 7 ILE A 644
LEU A 453
THR A 699
THR A 655
 None
 1.03A 5vc0A-1r8wA:
undetectable		 5vc0A-1r8wA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 12 LEU A 578
VAL A 563
PRO A 656
THR A 655
GLY A 649
 None
 1.27A 5xipC-1r8wA:
undetectable		 5xipC-1r8wA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 9 ASP A 538
LEU A  49
VAL A 208
SER A 211
 None
 0.90A 6c2mD-1r8wA:
undetectable		 6c2mD-1r8wA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		3 / 3 PHE A 306
ARG A  12
ALA A 240
 None
 0.99A 6ecfB-1r8wA:
2.3		 6ecfB-1r8wA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		5 / 10 SER A 661
GLY A 653
ARG A 455
LEU A 651
GLY A 649
 None
 1.09A 6hqbA-1r8wA:
4.3
6hqbJ-1r8wA:
undetectable		 6hqbA-1r8wA:
7.26
6hqbJ-1r8wA:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 7 ARG A 238
GLU A 241
CYH A 313
GLU A  70
 None
 1.30A 6mn5B-1r8wA:
undetectable		 6mn5B-1r8wA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1r8w GLYCEROL DEHYDRATASE
(Clostridium
butyricum) 		4 / 7 ASP A 235
ARG A 238
GLU A 241
CYH A 313
 None
 1.28A 6mn5B-1r8wA:
undetectable		 6mn5B-1r8wA:
7.55