SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r9j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		4 / 8 THR A 106
PRO A 107
GLY A 108
LEU A  87
 None
 0.56A 1h4oG-1r9jA:
undetectable		 1h4oG-1r9jA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		4 / 6 ILE A 144
VAL A 145
ILE A 426
ASP A 423
 None
 0.83A 1uwhB-1r9jA:
undetectable		 1uwhB-1r9jA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 12 MET A 622
TYR A 635
SER A 461
GLY A 621
ILE A 640
 None
 1.19A 2dcfA-1r9jA:
0.0		 2dcfA-1r9jA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		6 / 12 HIS A 422
GLY A 125
ASN A 417
LEU A 416
LEU A 126
PHE A 393
 None
 1.02A 2f8lA-1r9jA:
3.6		 2f8lA-1r9jA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		4 / 8 LEU A 173
ALA A 127
GLY A 418
LEU A 169
 None
 0.66A 2o4nB-1r9jA:
undetectable		 2o4nB-1r9jA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		4 / 7 ALA A 263
GLY A  25
VAL A  19
ASP A 269
 None
 0.81A 2uyqA-1r9jA:
3.2		 2uyqA-1r9jA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		4 / 6 PHE A 295
ALA A  73
LEU A  75
ALA A  78
 None
 0.91A 2vcvB-1r9jA:
undetectable		 2vcvB-1r9jA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		4 / 6 PHE A 295
ALA A  73
LEU A  75
ALA A  78
 None
 0.88A 2vcvK-1r9jA:
undetectable		 2vcvK-1r9jA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		4 / 7 THR A 106
PRO A 107
GLY A 108
LEU A  87
 None
 0.56A 2vl2B-1r9jA:
undetectable		 2vl2B-1r9jA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WET_B_TRPB650_0
(TRYPTOPHAN
5-HALOGENASE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 10 SER A 517
THR A 352
GLN A 519
GLU A 605
TYR A 635
 None
 1.44A 2wetB-1r9jA:
3.4		 2wetB-1r9jA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 10 TYR A 205
MET A 208
PHE A 210
ALA A 170
ALA A 166
 None
 1.27A 2wuzA-1r9jA:
undetectable		 2wuzA-1r9jA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 10 TYR A 205
MET A 208
PHE A 210
ALA A 170
ALA A 166
 None
 1.25A 2wuzB-1r9jA:
undetectable		 2wuzB-1r9jA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		4 / 6 ALA A  34
ALA A  38
THR A  42
PHE A 295
 None
 0.75A 2xfhA-1r9jA:
undetectable		 2xfhA-1r9jA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 11 SER A 507
LEU A 370
SER A 506
LEU A 505
LEU A 360
 None
 1.12A 2xn5A-1r9jA:
undetectable		 2xn5A-1r9jA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 12 ILE A 403
GLY A 373
PHE A 428
PHE A 364
ARG A 401
 None
 1.29A 2y7kC-1r9jA:
undetectable		 2y7kC-1r9jA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA512_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 10 MET A 622
TYR A 635
SER A 461
GLY A 621
ILE A 640
 None
 1.20A 2zm8A-1r9jA:
0.0		 2zm8A-1r9jA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 11 MET A 622
TYR A 635
SER A 461
GLY A 621
ILE A 640
 None
 1.19A 2zmaA-1r9jA:
0.0		 2zmaA-1r9jA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 12 MET A 622
TYR A 635
SER A 461
GLY A 621
ILE A 640
 None
 1.23A 3a65A-1r9jA:
0.0		 3a65A-1r9jA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 12 TYR A 635
ILE A 462
ALA A 551
SER A 552
SER A 554
 None
 1.21A 3apwA-1r9jA:
undetectable		 3apwA-1r9jA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		4 / 8 HIS A 132
GLY A 400
PHE A 137
ARG A 401
 None
 1.38A 3ccfA-1r9jA:
3.0		 3ccfA-1r9jA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 12 LEU A 419
ALA A 129
ALA A 127
VAL A 151
THR A 149
 None
 1.21A 3cwkA-1r9jA:
undetectable		 3cwkA-1r9jA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 12 GLY A 535
GLU A 496
VAL A 532
GLY A 531
VAL A 594
 None
 1.12A 3f8wA-1r9jA:
undetectable		 3f8wA-1r9jA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 12 GLY A 535
GLU A 496
VAL A 532
GLY A 531
VAL A 594
 None
 1.13A 3f8wB-1r9jA:
undetectable		 3f8wB-1r9jA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 12 GLY A 535
GLU A 496
VAL A 532
GLY A 531
VAL A 594
 None
 1.12A 3f8wC-1r9jA:
undetectable		 3f8wC-1r9jA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 12 LEU A 419
GLY A 418
ILE A 128
ALA A 166
LEU A 175
 None
 1.03A 3gwvA-1r9jA:
0.0		 3gwvA-1r9jA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		4 / 8 ILE A 489
SER A 492
SER A 576
SER A 527
 None
 0.95A 3lslA-1r9jA:
undetectable
3lslD-1r9jA:
undetectable		 3lslA-1r9jA:
16.96
3lslD-1r9jA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		4 / 8 SER A 527
ILE A 489
SER A 492
SER A 576
 None
 0.93A 3lslA-1r9jA:
undetectable
3lslD-1r9jA:
undetectable		 3lslA-1r9jA:
16.96
3lslD-1r9jA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 12 LEU A 547
ARG A 571
PRO A 600
GLY A 649
THR A 648
 None
 1.38A 3okxA-1r9jA:
undetectable		 3okxA-1r9jA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 12 LEU A 547
ARG A 571
PRO A 600
GLY A 649
THR A 648
 None
 1.12A 3okxB-1r9jA:
undetectable		 3okxB-1r9jA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		4 / 5 THR A 431
PHE A 432
ARG A 353
LEU A 382
 None
 1.11A 3qelC-1r9jA:
3.1		 3qelC-1r9jA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 10 LEU A 169
ALA A 127
GLY A 125
ILE A 415
CYH A 153
 None
 1.48A 3qpsA-1r9jA:
0.0		 3qpsA-1r9jA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		4 / 8 ILE A 273
PHE A 277
THR A 246
VAL A 260
 None
 0.83A 3ua5A-1r9jA:
0.5		 3ua5A-1r9jA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 11 GLN A  20
ASN A 272
GLY A 266
PRO A  27
GLY A 249
 None
 1.47A 4a6nB-1r9jA:
0.9		 4a6nB-1r9jA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		4 / 6 LEU A 360
LEU A 370
ILE A 426
TRP A 339
 None
 0.86A 4do3B-1r9jA:
0.0		 4do3B-1r9jA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		4 / 6 PHE A 393
GLY A 125
LEU A 175
VAL A 124
 None
 0.92A 4dubB-1r9jA:
undetectable		 4dubB-1r9jA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 11 ILE A  11
ALA A  34
GLY A  32
ASN A 217
TYR A 222
 None
 1.28A 4e47C-1r9jA:
undetectable		 4e47C-1r9jA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		3 / 3 PRO A 101
TYR A  72
GLY A  67
 None
 0.68A 4g2zA-1r9jA:
undetectable		 4g2zA-1r9jA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 12 ILE A  11
ALA A  34
GLY A  32
ASN A 217
TYR A 222
 None
 1.24A 4jlgA-1r9jA:
0.0		 4jlgA-1r9jA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_A_LYAA304_1
(FOLATE RECEPTOR BETA)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 12 ASP A 155
THR A 193
TYR A 186
GLY A 251
TYR A 182
 CA  A1670 ( 3.6A)
None
None
None
None
 1.24A 4kn2A-1r9jA:
0.0		 4kn2A-1r9jA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_B_LYAB304_1
(FOLATE RECEPTOR BETA)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 12 ASP A 155
THR A 193
TYR A 186
GLY A 251
TYR A 182
 CA  A1670 ( 3.6A)
None
None
None
None
 1.25A 4kn2B-1r9jA:
0.0		 4kn2B-1r9jA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_1
(FOLATE RECEPTOR BETA)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 12 ASP A 155
THR A 193
TYR A 186
GLY A 251
TYR A 182
 CA  A1670 ( 3.6A)
None
None
None
None
 1.24A 4kn2C-1r9jA:
0.0		 4kn2C-1r9jA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 12 ILE A 248
GLY A 249
PRO A  30
ALA A  15
VAL A 260
 TPP  A1671 (-4.4A)
None
None
None
None
 1.12A 4rvdA-1r9jA:
2.8		 4rvdA-1r9jA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 12 ILE A 248
GLY A 249
PRO A  30
ALA A  15
VAL A 260
 TPP  A1671 (-4.4A)
None
None
None
None
 1.13A 4rvgA-1r9jA:
3.4		 4rvgA-1r9jA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		3 / 3 VAL A 548
LEU A 545
VAL A 599
 None
 0.49A 4wq4A-1r9jA:
undetectable		 4wq4A-1r9jA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 10 GLY A 430
VAL A 456
THR A 378
SER A 356
LEU A 360
 None
 1.20A 4yb6A-1r9jA:
undetectable
4yb6E-1r9jA:
undetectable		 4yb6A-1r9jA:
19.76
4yb6E-1r9jA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 10 GLY A 430
VAL A 456
THR A 378
SER A 356
LEU A 360
 None
 1.19A 4yb6B-1r9jA:
2.0
4yb6C-1r9jA:
undetectable		 4yb6B-1r9jA:
19.76
4yb6C-1r9jA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 10 GLY A 430
VAL A 456
THR A 378
SER A 356
LEU A 360
 None
 1.20A 4yb6C-1r9jA:
undetectable
4yb6F-1r9jA:
undetectable		 4yb6C-1r9jA:
19.76
4yb6F-1r9jA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 10 SER A 356
LEU A 360
GLY A 430
VAL A 456
THR A 378
 None
 1.22A 4yb6A-1r9jA:
undetectable
4yb6D-1r9jA:
2.0		 4yb6A-1r9jA:
19.76
4yb6D-1r9jA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 10 SER A 356
LEU A 360
GLY A 430
VAL A 456
THR A 378
 None
 1.17A 4yb6D-1r9jA:
2.1
4yb6E-1r9jA:
undetectable		 4yb6D-1r9jA:
19.76
4yb6E-1r9jA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 10 SER A 356
LEU A 360
GLY A 430
VAL A 456
THR A 378
 None
 1.19A 4yb6B-1r9jA:
2.0
4yb6F-1r9jA:
undetectable		 4yb6B-1r9jA:
19.76
4yb6F-1r9jA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		4 / 6 ASP A 584
THR A 510
PRO A 511
THR A 512
 None
 1.13A 4yoaA-1r9jA:
undetectable		 4yoaA-1r9jA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		4 / 4 ILE A 462
ARG A 490
TYR A 635
GLU A 555
 None
 1.39A 4zzbD-1r9jA:
undetectable		 4zzbD-1r9jA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 11 ILE A  11
ALA A  34
GLY A  32
ASN A 217
TYR A 222
 None
 1.27A 5ayfA-1r9jA:
undetectable		 5ayfA-1r9jA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		4 / 4 ILE A 242
GLY A 224
ILE A 213
LEU A 225
 None
 0.90A 5dzkl-1r9jA:
undetectable
5dzkz-1r9jA:
undetectable		 5dzkl-1r9jA:
16.72
5dzkz-1r9jA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		4 / 6 LYS A 204
TYR A 205
GLY A 161
GLU A 160
 None
None
None
TPP  A1671 (-3.9A)
 0.95A 5emlA-1r9jA:
undetectable		 5emlA-1r9jA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		4 / 5 GLY A 418
ASP A 420
ARG A 103
MET A  45
 None
 1.41A 5gwkA-1r9jA:
1.4		 5gwkA-1r9jA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		3 / 3 LEU A 370
LEU A 505
ARG A 332
 None
 0.66A 5hnzB-1r9jA:
undetectable		 5hnzB-1r9jA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		3 / 3 VAL A 608
LEU A 486
MET A 483
 None
 0.77A 5ikrA-1r9jA:
undetectable		 5ikrA-1r9jA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 5 PRO A  35
ALA A  38
ALA A   8
ILE A  11
LEU A  70
 None
 1.19A 5jncD-1r9jA:
0.0		 5jncD-1r9jA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 12 GLY A 418
VAL A 111
VAL A 124
LEU A 126
HIS A 422
 None
 1.18A 5kocB-1r9jA:
undetectable		 5kocB-1r9jA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		3 / 3 PHE A  60
ASP A  58
LEU A 419
 None
 0.77A 5uhcC-1r9jA:
undetectable		 5uhcC-1r9jA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		4 / 7 VAL A 556
TYR A 537
GLU A 496
SER A 492
 None
 1.23A 5umwA-1r9jA:
undetectable
5umwF-1r9jA:
undetectable		 5umwA-1r9jA:
8.70
5umwF-1r9jA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 12 GLU A 496
GLY A 499
VAL A 477
LEU A 433
SER A 492
 None
 1.18A 5vooA-1r9jA:
undetectable		 5vooA-1r9jA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		5 / 12 GLU A 496
GLY A 499
VAL A 477
LEU A 433
SER A 492
 None
 1.18A 5vooC-1r9jA:
undetectable		 5vooC-1r9jA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		4 / 6 HIS A 619
ARG A 490
GLU A 605
TYR A 607
 None
 1.49A 5x7pA-1r9jA:
undetectable		 5x7pA-1r9jA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		3 / 3 GLU A 305
TRP A  54
HIS A 298
 None
 1.06A 5xipA-1r9jA:
3.6		 5xipA-1r9jA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1r9j TRANSKETOLASE
(Leishmania
mexicana) 		3 / 3 HIS A  66
HIS A 100
ARG A  91
 TPP  A1671 (-3.8A)
None
None
 1.02A 6b58A-1r9jA:
2.9		 6b58A-1r9jA:
22.97