SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1r9l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 1r9l GLYCINE
BETAINE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		3 / 3 PHE A 255
LEU A  31
LEU A  34
 None
 0.65A 1mx1E-1r9lA:
undetectable		 1mx1E-1r9lA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1r9l GLYCINE
BETAINE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		4 / 7 GLN A 268
MET A 272
ILE A 282
SER A  28
 None
 1.05A 2xytI-1r9lA:
undetectable		 2xytI-1r9lA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1r9l GLYCINE
BETAINE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		5 / 12 TYR A  96
ILE A 146
GLY A 144
ALA A 145
LEU A 213
 None
 1.11A 3n8xA-1r9lA:
undetectable		 3n8xA-1r9lA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1r9l GLYCINE
BETAINE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		5 / 11 TYR A  96
ILE A 146
GLY A 144
ALA A 145
LEU A 213
 None
 1.09A 3n8yA-1r9lA:
undetectable		 3n8yA-1r9lA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1r9l GLYCINE
BETAINE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		5 / 12 TYR A 153
GLY A  95
GLY A 230
ILE A 111
VAL A 208
 None
 1.09A 4a6dA-1r9lA:
undetectable		 4a6dA-1r9lA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 1r9l GLYCINE
BETAINE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		4 / 7 GLN A  94
THR A 187
LEU A  97
THR A 109
 None
 1.01A 4mbsA-1r9lA:
undetectable		 4mbsA-1r9lA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1r9l GLYCINE
BETAINE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 213
THR A 221
TRP A 205
TYR A  96
TYR A 186
 None
 1.41A 5dsgB-1r9lA:
undetectable		 5dsgB-1r9lA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_A_EDTA609_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1r9l GLYCINE
BETAINE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		4 / 8 TYR A 191
MET A 170
TRP A 188
THR A 134
 None
None
BET  A1001 (-3.7A)
None
 1.48A 5l8dA-1r9lA:
7.0		 5l8dA-1r9lA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_A_EDTA609_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1r9l GLYCINE
BETAINE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		4 / 8 TYR A 191
MET A 170
TRP A 188
THR A 134
 None
None
BET  A1001 (-3.7A)
None
 1.48A 5mwuA-1r9lA:
7.0		 5mwuA-1r9lA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 1r9l GLYCINE
BETAINE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		5 / 10 TYR A  96
ILE A 111
LEU A 150
ALA A 145
LEU A 213
 None
 1.17A 5y7pG-1r9lA:
0.0		 5y7pG-1r9lA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 1r9l GLYCINE
BETAINE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 223
GLY A 230
ASP A 220
VAL A 208
ILE A 111
 None
 0.80A 6ecxA-1r9lA:
undetectable		 6ecxA-1r9lA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1r9l GLYCINE
BETAINE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		3 / 3 THR A  66
GLU A  20
ASN A  64
 None
 0.61A 6nj9K-1r9lA:
undetectable		 6nj9K-1r9lA:
20.13