SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rc2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1rc2 AQUAPORIN Z
(Escherichia
coli) 		4 / 8 ARG B 189
GLN B 197
ASN B 182
TRP B 200
 None
 1.33A 1p6kB-1rc2B:
0.7		 1p6kB-1rc2B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1rc2 AQUAPORIN Z
(Escherichia
coli) 		4 / 8 ARG B 189
GLN B 197
ASN B 182
TRP B 200
 None
 1.32A 1rs6B-1rc2B:
0.6		 1rs6B-1rc2B:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1rc2 AQUAPORIN Z
(Escherichia
coli) 		4 / 8 ARG B 189
GLN B 197
ASN B 182
TRP B 200
 None
 1.31A 1rs7B-1rc2B:
undetectable		 1rs7B-1rc2B:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1rc2 AQUAPORIN Z
(Escherichia
coli) 		4 / 8 ARG B 189
GLN B 197
ASN B 182
TRP B 200
 None
 1.32A 1zzuB-1rc2B:
0.7		 1zzuB-1rc2B:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 1rc2 AQUAPORIN Z
(Escherichia
coli) 		4 / 7 PHE B 145
LEU B  15
VAL B  47
THR B  46
 None
 0.95A 2qblA-1rc2B:
undetectable		 2qblA-1rc2B:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1rc2 AQUAPORIN Z
(Escherichia
coli) 		4 / 7 ILE B 213
GLN B  88
LEU B 146
GLY B 216
 None
 0.92A 2qqcD-1rc2B:
undetectable
2qqcE-1rc2B:
undetectable		 2qqcD-1rc2B:
19.48
2qqcE-1rc2B:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1rc2 AQUAPORIN Z
(Escherichia
coli) 		4 / 8 ILE B 213
GLN B  88
LEU B 146
GLY B 216
 None
 0.91A 2qqcH-1rc2B:
undetectable
2qqcK-1rc2B:
undetectable		 2qqcH-1rc2B:
19.48
2qqcK-1rc2B:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1rc2 AQUAPORIN Z
(Escherichia
coli) 		5 / 12 GLY B 198
GLY B 199
TRP B 200
LEU B  99
ALA B 117
 BGL  B 603 (-3.9A)
BGL  B 602 ( 3.8A)
None
None
None
 0.81A 3douA-1rc2B:
undetectable		 3douA-1rc2B:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1rc2 AQUAPORIN Z
(Escherichia
coli) 		3 / 3 ASN B 186
ASN B 119
GLU B 138
 None
 0.83A 3kpdB-1rc2B:
undetectable		 3kpdB-1rc2B:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1rc2 AQUAPORIN Z
(Escherichia
coli) 		5 / 11 GLU B   8
GLY B  91
ALA B  87
ILE B  93
ALA B 192
 None
 0.91A 3nmuB-1rc2B:
undetectable
3nmuJ-1rc2B:
undetectable		 3nmuB-1rc2B:
19.89
3nmuJ-1rc2B:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 1rc2 AQUAPORIN Z
(Escherichia
coli) 		4 / 7 ALA B  65
GLY B 220
ILE B 218
GLY B 215
 None
 0.68A 4eatA-1rc2B:
undetectable		 4eatA-1rc2B:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1rc2 AQUAPORIN Z
(Escherichia
coli) 		5 / 9 ALA B 162
ALA B 165
GLY B  59
GLY B  60
ALA B  51
 None
 1.07A 4qvmK-1rc2B:
undetectable
4qvmL-1rc2B:
undetectable		 4qvmK-1rc2B:
25.41
4qvmL-1rc2B:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 1rc2 AQUAPORIN Z
(Escherichia
coli) 		4 / 7 SER B 118
GLY B 198
GLY B 199
ALA B 201
 None
BGL  B 603 (-3.9A)
BGL  B 602 ( 3.8A)
None
 0.68A 4yjiA-1rc2B:
undetectable		 4yjiA-1rc2B:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1rc2 AQUAPORIN Z
(Escherichia
coli) 		5 / 9 ALA B 162
ALA B 165
GLY B  59
GLY B  60
ALA B  51
 None
 1.07A 5d0xK-1rc2B:
undetectable
5d0xL-1rc2B:
undetectable		 5d0xK-1rc2B:
25.00
5d0xL-1rc2B:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1rc2 AQUAPORIN Z
(Escherichia
coli) 		5 / 9 ALA B 162
ALA B 165
GLY B  59
GLY B  60
ALA B  51
 None
 1.07A 5d0xY-1rc2B:
undetectable
5d0xZ-1rc2B:
undetectable		 5d0xY-1rc2B:
25.00
5d0xZ-1rc2B:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 1rc2 AQUAPORIN Z
(Escherichia
coli) 		6 / 9 SER B 190
GLY B 216
SER B 142
ASN B  63
ILE B  68
ALA B  72
 None
 1.49A 5entC-1rc2B:
undetectable		 5entC-1rc2B:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1rc2 AQUAPORIN Z
(Escherichia
coli) 		4 / 7 ASN B 182
ALA B 201
VAL B 193
ARG B 189
 None
 0.86A 5fpdA-1rc2B:
undetectable		 5fpdA-1rc2B:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1rc2 AQUAPORIN Z
(Escherichia
coli) 		4 / 7 ASN B 182
ALA B 201
VAL B 193
ARG B 189
 None
 0.88A 5fpdB-1rc2B:
undetectable		 5fpdB-1rc2B:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 1rc2 AQUAPORIN Z
(Escherichia
coli) 		4 / 8 LEU B 227
LEU B 226
LEU B 146
GLY B 216
 None
 0.90A 6ce2A-1rc2B:
undetectable		 6ce2A-1rc2B:
17.52