SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rc7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 9 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.34A 1bkfA-1rc7A:
undetectable		 1bkfA-1rc7A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 12 LEU A  46
VAL A  47
SER A 120
LEU A  87
LEU A  11
 None
 1.12A 1s19A-1rc7A:
undetectable		 1s19A-1rc7A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		3 / 3 GLU A 187
THR A 195
LEU A 156
 None
 0.61A 1v8bC-1rc7A:
undetectable		 1v8bC-1rc7A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 11 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.28A 1yatA-1rc7A:
undetectable		 1yatA-1rc7A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 11 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.42A 2fkeA-1rc7A:
undetectable		 2fkeA-1rc7A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_B_FK5B501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 10 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.33A 2vn1B-1rc7A:
undetectable		 2vn1B-1rc7A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 11 PHE A 109
ILE A  51
PHE A  80
SER A  76
PHE A 131
 None
 1.36A 3a9eB-1rc7A:
undetectable		 3a9eB-1rc7A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 11 PHE A 109
ILE A  51
SER A  76
PHE A 131
LEU A  11
 None
 1.23A 3a9eB-1rc7A:
undetectable		 3a9eB-1rc7A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 10 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.35A 3ihzA-1rc7A:
undetectable		 3ihzA-1rc7A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 10 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.30A 3uf8A-1rc7A:
undetectable		 3uf8A-1rc7A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 10 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.28A 3uqaA-1rc7A:
undetectable		 3uqaA-1rc7A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 11 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.36A 3vawA-1rc7A:
undetectable		 3vawA-1rc7A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 11 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.33A 4dz2A-1rc7A:
undetectable
4dz2B-1rc7A:
undetectable		 4dz2A-1rc7A:
16.59
4dz2B-1rc7A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_B_FK5B200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 11 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.36A 4dz2A-1rc7A:
undetectable
4dz2B-1rc7A:
undetectable		 4dz2A-1rc7A:
16.59
4dz2B-1rc7A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 10 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.35A 4dz3A-1rc7A:
undetectable		 4dz3A-1rc7A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 10 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.34A 4dz3B-1rc7A:
undetectable		 4dz3B-1rc7A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		3 / 3 GLY A 197
GLU A 187
THR A 195
 None
 0.59A 4kouA-1rc7A:
undetectable		 4kouA-1rc7A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 12 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.32A 4nnrA-1rc7A:
undetectable
4nnrB-1rc7A:
undetectable		 4nnrA-1rc7A:
22.12
4nnrB-1rc7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 10 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.30A 4nnrB-1rc7A:
undetectable		 4nnrB-1rc7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 10 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.40A 4qt3A-1rc7A:
undetectable		 4qt3A-1rc7A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		4 / 7 ALA A 142
ILE A  51
LEU A  83
PHE A  79
 None
 0.91A 4uymB-1rc7A:
undetectable		 4uymB-1rc7A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 8 ALA A 111
LEU A  89
LEU A   7
LEU A  21
ALA A 115
 None
 0.91A 4z90A-1rc7A:
undetectable
4z90B-1rc7A:
undetectable
4z90C-1rc7A:
undetectable
4z90D-1rc7A:
undetectable
4z90E-1rc7A:
undetectable		 4z90A-1rc7A:
21.13
4z90B-1rc7A:
21.13
4z90C-1rc7A:
21.13
4z90D-1rc7A:
21.13
4z90E-1rc7A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 11 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.30A 5huaA-1rc7A:
undetectable		 5huaA-1rc7A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		4 / 8 ASP A 138
VAL A  47
ILE A  51
PHE A  79
 None
 0.79A 5hw8H-1rc7A:
undetectable		 5hw8H-1rc7A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 11 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.27A 5hwcA-1rc7A:
undetectable		 5hwcA-1rc7A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		4 / 8 PHE A  50
VAL A 116
SER A 120
TYR A 117
 None
 1.05A 6huoC-1rc7A:
undetectable
6huoD-1rc7A:
undetectable		 6huoC-1rc7A:
16.75
6huoD-1rc7A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 12 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.30A 6mkeA-1rc7A:
undetectable
6mkeD-1rc7A:
undetectable		 6mkeA-1rc7A:
16.06
6mkeD-1rc7A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 12 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.30A 6mkeB-1rc7A:
undetectable
6mkeC-1rc7A:
undetectable		 6mkeB-1rc7A:
16.06
6mkeC-1rc7A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 10 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.30A 6mkeC-1rc7A:
undetectable		 6mkeC-1rc7A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_1
(PEPTIDYLPROLYL
ISOMERASE)		 1rc7 RIBONUCLEASE III
(Aquifex
aeolicus) 		5 / 10 ASP A 138
PHE A 109
VAL A  47
ILE A  51
PHE A  79
 None
 1.28A 6mkeD-1rc7A:
undetectable		 6mkeD-1rc7A:
16.06