SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rcq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 137
GLU A 142
LEU A 144
VAL A 119
 None
 1.06A 1hk1A-1rcqA:
0.0		 1hk1A-1rcqA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 225
ALA A  20
LEU A 197
SER A 193
 None
None
None
PLP  A 358 (-2.6A)
 1.29A 1tyrA-1rcqA:
undetectable		 1tyrA-1rcqA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		5 / 12 SER A 193
ALA A 216
GLY A 215
LEU A 229
VAL A  31
 PLP  A 358 (-2.6A)
None
None
None
PLP  A 358 (-4.4A)
 1.16A 1vpoH-1rcqA:
0.0
1vpoL-1rcqA:
0.0		 1vpoH-1rcqA:
21.37
1vpoL-1rcqA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 210
GLY A 215
VAL A  31
ALA A  30
LEU A  78
 PLP  A 358 (-3.3A)
None
PLP  A 358 (-4.4A)
None
PLP  A 358 ( 4.2A)
 0.96A 1vptA-1rcqA:
undetectable		 1vptA-1rcqA:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XQL_A_4AXA605_1
(ALANINE RACEMASE)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		4 / 8 LYS A  33
TYR A  37
ARG A 129
TYR A 341
 PLP  A 358 ( 1.3A)
PLP  A 358 ( 4.6A)
DLY  A 359 ( 2.5A)
PLP  A 358 ( 4.4A)
 0.68A 1xqlA-1rcqA:
39.4
1xqlB-1rcqA:
39.6		 1xqlA-1rcqA:
31.98
1xqlB-1rcqA:
31.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XQL_B_4AXB505_1
(ALANINE RACEMASE)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		4 / 8 LYS A  33
TYR A  37
ARG A 129
TYR A 341
 PLP  A 358 ( 1.3A)
PLP  A 358 ( 4.6A)
DLY  A 359 ( 2.5A)
PLP  A 358 ( 4.4A)
 0.78A 1xqlA-1rcqA:
39.4
1xqlB-1rcqA:
39.6		 1xqlA-1rcqA:
31.98
1xqlB-1rcqA:
31.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 315
ALA A 314
ILE A 265
VAL A 286
ILE A 288
 None
 0.81A 2avvB-1rcqA:
undetectable		 2avvB-1rcqA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 315
ALA A 314
ILE A 265
VAL A 286
ILE A 288
 None
 0.82A 2fxeA-1rcqA:
undetectable		 2fxeA-1rcqA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_2
(PROTEASE)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 315
ALA A 314
ILE A 265
VAL A 286
ILE A 288
 None
 0.94A 2hs2B-1rcqA:
undetectable		 2hs2B-1rcqA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		4 / 5 VAL A 267
THR A 305
VAL A 251
GLY A 252
 None
 1.04A 2p2fA-1rcqA:
undetectable		 2p2fA-1rcqA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		4 / 4 VAL A 267
THR A 305
VAL A 251
GLY A 252
 None
 1.02A 2p2fB-1rcqA:
undetectable		 2p2fB-1rcqA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_2
(PROTEASE RETROPEPSIN)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 315
ALA A 314
ILE A 265
VAL A 286
ILE A 288
 None
 0.98A 2qhcB-1rcqA:
undetectable		 2qhcB-1rcqA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		3 / 3 TRP A  96
VAL A 150
TRP A 120
 None
 1.30A 2xdcC-1rcqA:
undetectable
2xdcD-1rcqA:
undetectable		 2xdcC-1rcqA:
4.32
2xdcD-1rcqA:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		3 / 3 TRP A  96
VAL A 150
TRP A 120
 None
 1.25A 2xdcE-1rcqA:
undetectable
2xdcF-1rcqA:
undetectable		 2xdcE-1rcqA:
4.32
2xdcF-1rcqA:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		3 / 3 TRP A  96
VAL A 150
TRP A 120
 None
 1.30A 2y5mE-1rcqA:
undetectable
2y5mF-1rcqA:
undetectable		 2y5mE-1rcqA:
4.32
2y5mF-1rcqA:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		3 / 3 TRP A  96
VAL A 150
TRP A 120
 None
 1.30A 2y6nC-1rcqA:
undetectable
2y6nD-1rcqA:
undetectable		 2y6nC-1rcqA:
4.32
2y6nD-1rcqA:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		3 / 3 TRP A  96
VAL A 150
TRP A 120
 None
 1.30A 2y6nE-1rcqA:
undetectable
2y6nF-1rcqA:
undetectable		 2y6nE-1rcqA:
4.32
2y6nF-1rcqA:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		4 / 7 ARG A 169
GLU A 171
ALA A 176
ALA A 175
 None
 1.14A 2zgwA-1rcqA:
undetectable		 2zgwA-1rcqA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 315
ALA A 314
ILE A 265
VAL A 286
ILE A 288
 None
 0.82A 3cywB-1rcqA:
undetectable		 3cywB-1rcqA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 315
ALA A 314
ILE A 265
VAL A 286
ILE A 288
 None
 0.80A 3d20B-1rcqA:
undetectable		 3d20B-1rcqA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_2
(GAG-POL POLYPROTEIN)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 315
ALA A 314
ILE A 265
VAL A 286
ILE A 288
 None
 0.84A 3jvyB-1rcqA:
undetectable		 3jvyB-1rcqA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 315
ALA A 314
ILE A 265
VAL A 286
ILE A 288
 None
 0.82A 3jw2B-1rcqA:
undetectable		 3jw2B-1rcqA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 296
VAL A 242
ILE A 288
ARG A 261
 None
 0.98A 3ms9A-1rcqA:
undetectable		 3ms9A-1rcqA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 296
VAL A 242
ILE A 288
ARG A 261
 None
 1.00A 3mssA-1rcqA:
undetectable		 3mssA-1rcqA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 296
VAL A 242
ILE A 288
ARG A 261
 None
 0.97A 3mssC-1rcqA:
undetectable		 3mssC-1rcqA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_1
(PROTEASE)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 315
ALA A 314
ILE A 265
VAL A 286
ILE A 288
 None
 0.91A 3nduA-1rcqA:
undetectable		 3nduA-1rcqA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		5 / 7 ALA A 314
SER A 318
VAL A 320
VAL A 239
LEU A 308
 None
 1.34A 3o14A-1rcqA:
undetectable		 3o14A-1rcqA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		5 / 12 GLU A  46
ALA A  47
GLY A 356
ASP A   9
ALA A  49
 None
 1.18A 3ou6C-1rcqA:
undetectable		 3ou6C-1rcqA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_2
(PROTEASE)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 315
ALA A 314
ILE A 265
VAL A 286
ILE A 288
 None
 0.95A 3pwmB-1rcqA:
undetectable		 3pwmB-1rcqA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 315
ALA A 314
ILE A 265
VAL A 286
ILE A 288
 None
 0.84A 3tkwA-1rcqA:
undetectable		 3tkwA-1rcqA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 315
ALA A 314
ILE A 265
VAL A 286
ILE A 288
 None
 0.85A 3tkwB-1rcqA:
undetectable		 3tkwB-1rcqA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		5 / 9 ALA A  34
GLY A  38
LEU A 344
ASN A 346
ILE A 211
 None
None
None
None
PLP  A 358 (-3.9A)
 1.26A 3wdmA-1rcqA:
undetectable		 3wdmA-1rcqA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		3 / 3 TRP A  96
VAL A 150
TRP A 120
 None
 1.19A 3zq8A-1rcqA:
undetectable
3zq8B-1rcqA:
undetectable		 3zq8A-1rcqA:
4.32
3zq8B-1rcqA:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 315
ALA A 314
ILE A 265
VAL A 286
ILE A 288
 None
 0.88A 4hlaB-1rcqA:
undetectable		 4hlaB-1rcqA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 225
ALA A  20
LEU A 197
SER A 193
 None
None
None
PLP  A 358 (-2.6A)
 1.23A 5a6iA-1rcqA:
undetectable		 5a6iA-1rcqA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		5 / 12 TYR A  17
GLY A  54
PRO A 209
ASP A  94
ASP A  53
 None
 1.28A 5yn6A-1rcqA:
undetectable		 5yn6A-1rcqA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		5 / 12 TYR A  17
GLY A  54
PRO A 209
ASP A  94
ASP A  53
 None
 1.27A 5yniA-1rcqA:
undetectable		 5yniA-1rcqA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		5 / 12 TYR A  17
GLY A  54
PRO A 209
ASP A  94
ASP A  53
 None
 1.30A 5ynmA-1rcqA:
undetectable		 5ynmA-1rcqA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 315
ALA A 314
ILE A 265
VAL A 286
ILE A 288
 None
 0.81A 6difB-1rcqA:
undetectable		 6difB-1rcqA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 1rcq CATABOLIC ALANINE
RACEMASE DADX
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 205
SER A 178
SER A 181
 None
 0.81A 6mxtA-1rcqA:
undetectable		 6mxtA-1rcqA:
22.06