SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rcu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 1rcu CONSERVED
HYPOTHETICAL PROTEIN
VT76
(Thermotoga
maritima) 		6 / 9 LEU A  21
ILE A 103
GLY A   8
SER A  19
LEU A  50
CYH A  25
 None
 1.45A 2qmmA-1rcuA:
2.0		 2qmmA-1rcuA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 1rcu CONSERVED
HYPOTHETICAL PROTEIN
VT76
(Thermotoga
maritima) 		6 / 11 LEU A  21
ILE A 103
GLY A   8
SER A  19
LEU A  50
CYH A  25
 None
 1.43A 2qmmA-1rcuA:
2.1
2qmmB-1rcuA:
undetectable		 2qmmA-1rcuA:
20.28
2qmmB-1rcuA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ9_A_CLSA11_1
(BETA-LACTAMASE
TOHO-1)		 1rcu CONSERVED
HYPOTHETICAL PROTEIN
VT76
(Thermotoga
maritima) 		4 / 4 GLU A  70
ARG A  44
ASN A  73
ASP A  45
 None
 1.03A 2zq9A-1rcuA:
undetectable		 2zq9A-1rcuA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 1rcu CONSERVED
HYPOTHETICAL PROTEIN
VT76
(Thermotoga
maritima) 		6 / 9 LEU A  21
ILE A 103
GLY A   8
SER A  19
LEU A  50
CYH A  25
 None
 1.37A 3ai9X-1rcuA:
undetectable		 3ai9X-1rcuA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1rcu CONSERVED
HYPOTHETICAL PROTEIN
VT76
(Thermotoga
maritima) 		5 / 9 ALA A  58
VAL A   4
GLY A  36
SER A  77
VAL A  39
 None
 1.30A 4r20B-1rcuA:
undetectable		 4r20B-1rcuA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1rcu CONSERVED
HYPOTHETICAL PROTEIN
VT76
(Thermotoga
maritima) 		5 / 12 GLY A  42
TYR A  75
SER A  52
SER A  90
GLN A  87
 None
 1.37A 4xueB-1rcuA:
3.0		 4xueB-1rcuA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1rcu CONSERVED
HYPOTHETICAL PROTEIN
VT76
(Thermotoga
maritima) 		5 / 7 SER A 102
ASP A  45
ARG A  44
GLY A  43
GLU A  70
 None
 1.48A 5btaA-1rcuA:
undetectable
5btaC-1rcuA:
undetectable
5btaD-1rcuA:
2.0		 5btaA-1rcuA:
19.79
5btaC-1rcuA:
19.79
5btaD-1rcuA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1rcu CONSERVED
HYPOTHETICAL PROTEIN
VT76
(Thermotoga
maritima) 		5 / 7 SER A 102
ASP A  45
ARG A  44
GLY A  43
GLU A  70
 None
 1.41A 5btfA-1rcuA:
undetectable
5btfB-1rcuA:
undetectable
5btfC-1rcuA:
undetectable		 5btfA-1rcuA:
19.79
5btfB-1rcuA:
20.38
5btfC-1rcuA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1rcu CONSERVED
HYPOTHETICAL PROTEIN
VT76
(Thermotoga
maritima) 		3 / 3 MET A  88
GLN A  87
ARG A  89
 None
 1.08A 5ewzB-1rcuA:
undetectable		 5ewzB-1rcuA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1rcu CONSERVED
HYPOTHETICAL PROTEIN
VT76
(Thermotoga
maritima) 		3 / 3 MET A  88
GLN A  87
ARG A  89
 None
 1.07A 5m35B-1rcuA:
undetectable		 5m35B-1rcuA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1rcu CONSERVED
HYPOTHETICAL PROTEIN
VT76
(Thermotoga
maritima) 		3 / 3 MET A  88
GLN A  87
ARG A  89
 None
 1.01A 5m36A-1rcuA:
undetectable		 5m36A-1rcuA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 1rcu CONSERVED
HYPOTHETICAL PROTEIN
VT76
(Thermotoga
maritima) 		5 / 12 SER A  90
LEU A  93
GLY A  46
GLU A  70
GLY A  11
 None
 1.02A 5veuH-1rcuA:
undetectable		 5veuH-1rcuA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1rcu CONSERVED
HYPOTHETICAL PROTEIN
VT76
(Thermotoga
maritima) 		3 / 3 MET A  88
GLN A  87
ARG A  89
 None
 1.07A 6fn9A-1rcuA:
undetectable		 6fn9A-1rcuA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1rcu CONSERVED
HYPOTHETICAL PROTEIN
VT76
(Thermotoga
maritima) 		3 / 3 MET A  88
GLN A  87
ARG A  89
 None
 1.08A 6fnaB-1rcuA:
undetectable		 6fnaB-1rcuA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1rcu CONSERVED
HYPOTHETICAL PROTEIN
VT76
(Thermotoga
maritima) 		3 / 3 MET A  88
GLN A  87
ARG A  89
 None
 1.06A 6fnbA-1rcuA:
undetectable		 6fnbA-1rcuA:
18.97