SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1re5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE
(Pseudomonas
putida) 		5 / 12 GLY A 113
PHE A 236
LEU A 188
MET A  15
ALA A 121
 None
 1.38A 1e3vA-1re5A:
undetectable		 1e3vA-1re5A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_B_DXCB801_0
(STEROID
DELTA-ISOMERASE)		 1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE
(Pseudomonas
putida) 		5 / 11 GLY A 113
PHE A 236
LEU A 188
MET A  15
ALA A 121
 None
 1.39A 1e3vB-1re5A:
undetectable		 1e3vB-1re5A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE
(Pseudomonas
putida) 		3 / 3 ALA A 214
VAL A 189
TRP A 226
 None
 0.83A 1gmkC-1re5A:
undetectable
1gmkD-1re5A:
undetectable		 1gmkC-1re5A:
5.05
1gmkD-1re5A:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE
(Pseudomonas
putida) 		5 / 9 LEU A  35
PHE A  31
GLY A 194
LEU A 221
LEU A 190
 None
 0.98A 1nr6A-1re5A:
undetectable		 1nr6A-1re5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE
(Pseudomonas
putida) 		4 / 7 PHE A 192
GLU A  32
LEU A  35
THR A 105
 None
 1.07A 1rmtB-1re5A:
undetectable		 1rmtB-1re5A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE
(Pseudomonas
putida) 		5 / 12 LEU A 388
CYH A 392
ALA A 395
GLU A 398
LEU A 421
 None
 1.12A 1s9pB-1re5A:
undetectable		 1s9pB-1re5A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE
(Pseudomonas
putida) 		5 / 10 ILE A 344
LEU A 162
LEU A 257
ILE A 254
PHE A 250
 None
 1.21A 2w9sD-1re5A:
undetectable		 2w9sD-1re5A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE
(Pseudomonas
putida) 		5 / 10 ILE A 344
LEU A 162
LEU A 257
ILE A 254
PHE A 250
 None
 1.18A 2w9sF-1re5A:
undetectable		 2w9sF-1re5A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE
(Pseudomonas
putida) 		4 / 8 LEU A 338
ILE A 125
LEU A 129
LEU A 247
 None
 0.68A 2xfhA-1re5A:
2.0		 2xfhA-1re5A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE
(Pseudomonas
putida) 		6 / 12 ALA A 104
LEU A  35
ASP A 108
LEU A 221
ALA A 206
THR A 105
 None
 1.47A 3dfrA-1re5A:
undetectable		 3dfrA-1re5A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE
(Pseudomonas
putida) 		5 / 8 LEU A 132
VAL A 243
LEU A 247
ILE A 125
VAL A 334
 None
 1.31A 3kp6A-1re5A:
undetectable
3kp6B-1re5A:
0.6		 3kp6A-1re5A:
14.57
3kp6B-1re5A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE
(Pseudomonas
putida) 		3 / 3 VAL A 169
SER A 246
LEU A 173
 None
 0.73A 3n8xA-1re5A:
undetectable		 3n8xA-1re5A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE
(Pseudomonas
putida) 		5 / 12 TYR A   9
LYS A 131
ALA A  12
PHE A  10
ALA A 294
 None
 1.05A 3nmuA-1re5A:
1.3
3nmuF-1re5A:
undetectable		 3nmuA-1re5A:
22.89
3nmuF-1re5A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE
(Pseudomonas
putida) 		4 / 5 SER A 255
ARG A 252
LEU A 256
ASP A 253
 None
 1.41A 4ifxA-1re5A:
0.0		 4ifxA-1re5A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE
(Pseudomonas
putida) 		4 / 5 SER A 255
ARG A 252
LEU A 256
ASP A 253
 None
 1.39A 4ig1A-1re5A:
0.0		 4ig1A-1re5A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE
(Pseudomonas
putida) 		4 / 6 VAL A 243
LEU A 242
LEU A 180
PHE A  19
 None
 0.99A 4o1zA-1re5A:
undetectable		 4o1zA-1re5A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE
(Pseudomonas
putida) 		5 / 11 LEU A 173
LEU A 129
LEU A 247
VAL A 239
LEU A 240
 None
 1.14A 4p65C-1re5A:
undetectable
4p65D-1re5A:
undetectable
4p65J-1re5A:
undetectable
4p65L-1re5A:
undetectable		 4p65C-1re5A:
3.99
4p65D-1re5A:
5.12
4p65J-1re5A:
5.12
4p65L-1re5A:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE
(Pseudomonas
putida) 		4 / 8 LEU A 114
PHE A  19
ILE A  18
LEU A 187
 None
 0.77A 5eseA-1re5A:
undetectable		 5eseA-1re5A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE
(Pseudomonas
putida) 		4 / 4 ARG A 177
GLN A 138
PHE A 448
LEU A 141
 None
 1.43A 5uhgC-1re5A:
0.8		 5uhgC-1re5A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE
(Pseudomonas
putida) 		3 / 3 LEU A  67
ALA A  68
LEU A  25
 None
 0.52A 5uunB-1re5A:
undetectable		 5uunB-1re5A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE
(Pseudomonas
putida) 		4 / 8 GLY A 248
ALA A 295
GLY A 251
SER A 255
 None
 0.74A 5vw9A-1re5A:
undetectable		 5vw9A-1re5A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE
(Pseudomonas
putida) 		5 / 12 ALA A 288
PHE A 250
VAL A 343
GLY A 347
LEU A 166
 None
 1.08A 5x24A-1re5A:
0.3		 5x24A-1re5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE
(Pseudomonas
putida) 		5 / 12 VAL A 169
GLN A 342
VAL A 265
GLY A 251
LEU A 173
 None
 1.03A 5xxiA-1re5A:
undetectable		 5xxiA-1re5A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE
(Pseudomonas
putida) 		5 / 12 GLY A 103
TYR A  99
ALA A 195
ALA A 201
ALA A 200
 None
 1.04A 5zw4A-1re5A:
undetectable		 5zw4A-1re5A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE
(Pseudomonas
putida) 		5 / 12 SER A 246
HIS A 176
VAL A 169
LEU A 333
ALA A 294
 None
 1.04A 6djzC-1re5A:
undetectable		 6djzC-1re5A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE
(Pseudomonas
putida) 		5 / 11 ALA A 337
LEU A 247
ALA A 133
THR A 135
ALA A 345
 None
 1.31A 6h1lB-1re5A:
undetectable		 6h1lB-1re5A:
20.85