SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rep'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1rep PROTEIN (REPLICATION
INITIATION PROTEIN)
(Escherichia
coli) 		5 / 12 TYR C 192
LEU C 169
ILE C 188
PHE C 208
PHE C 240
 None
 1.35A 1xmuA-1repC:
undetectable		 1xmuA-1repC:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1rep PROTEIN (REPLICATION
INITIATION PROTEIN)
(Escherichia
coli) 		5 / 12 TYR C 192
LEU C 169
ILE C 188
PHE C 204
PHE C 240
 None
 1.44A 1xomA-1repC:
undetectable		 1xomA-1repC:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1rep PROTEIN (REPLICATION
INITIATION PROTEIN)
(Escherichia
coli) 		5 / 12 TYR C 192
LEU C 169
ILE C 188
PHE C 204
PHE C 240
 None
 1.43A 1xomB-1repC:
undetectable		 1xomB-1repC:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 1rep PROTEIN (REPLICATION
INITIATION PROTEIN)
(Escherichia
coli) 		4 / 8 PHE C 139
ALA C  27
LEU C  31
LEU C  39
 None
 0.87A 4ejgB-1repC:
undetectable		 4ejgB-1repC:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 1rep PROTEIN (REPLICATION
INITIATION PROTEIN)
(Escherichia
coli) 		4 / 7 PHE C 139
ALA C  27
LEU C  31
LEU C  39
 None
 0.83A 4ejgC-1repC:
0.0		 4ejgC-1repC:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 1rep PROTEIN (REPLICATION
INITIATION PROTEIN)
(Escherichia
coli) 		4 / 6 THR C 220
LEU C 224
TYR C 166
LEU C 169
 None
 0.98A 4wozA-1repC:
undetectable
4wozB-1repC:
undetectable		 4wozA-1repC:
19.81
4wozB-1repC:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 1rep PROTEIN (REPLICATION
INITIATION PROTEIN)
(Escherichia
coli) 		4 / 5 LEU C 224
TYR C 166
LEU C 169
THR C 220
 None
 0.97A 4wozF-1repC:
0.0
4wozH-1repC:
undetectable		 4wozF-1repC:
19.81
4wozH-1repC:
19.81