SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rf5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 8 GLY A 100
GLY A 133
LEU A 155
GLY A 151
 None
 0.70A 1d0vA-1rf5A:
undetectable		 1d0vA-1rf5A:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 8 GLY A 100
GLY A 133
LEU A 155
GLY A 151
 None
 0.66A 1jhaA-1rf5A:
undetectable		 1jhaA-1rf5A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 8 GLY A 100
GLY A 133
LEU A 155
GLY A 151
 None
 0.70A 1jhqA-1rf5A:
undetectable		 1jhqA-1rf5A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 8 GLY A 100
GLY A 133
LEU A 155
GLY A 151
 None
 0.73A 1jhvA-1rf5A:
undetectable		 1jhvA-1rf5A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 10 ALA A 176
LEU A 129
PRO A 128
ALA A 103
GLY A 151
 None
 1.21A 1mjqG-1rf5A:
undetectable
1mjqH-1rf5A:
undetectable		 1mjqG-1rf5A:
14.50
1mjqH-1rf5A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 129
GLY A 100
THR A  51
VAL A  54
LEU A 149
 None
 0.84A 1mx1C-1rf5A:
undetectable		 1mx1C-1rf5A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 155
GLY A 151
LEU A  79
GLY A  78
PRO A 219
 None
 1.20A 1y4lA-1rf5A:
undetectable		 1y4lA-1rf5A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 5 LEU A 253
PRO A  17
VAL A  16
ILE A  14
 None
 1.01A 2aoiB-1rf5A:
undetectable		 2aoiB-1rf5A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 11 SER A 171
GLN A 168
ALA A 167
ALA A 176
GLY A 100
 None
 1.19A 2f16H-1rf5A:
undetectable
2f16I-1rf5A:
undetectable		 2f16H-1rf5A:
20.51
2f16I-1rf5A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A 291
LEU A 276
LEU A 240
PRO A 283
THR A 289
 None
 1.13A 3dcjA-1rf5A:
undetectable
3dcjB-1rf5A:
undetectable		 3dcjA-1rf5A:
19.86
3dcjB-1rf5A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		3 / 3 SER A  91
GLY A  92
THR A  93
 None
 0.16A 3k9wA-1rf5A:
undetectable		 3k9wA-1rf5A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 ASP A 419
LEU A 424
TRP A 239
TYR A 414
PHE A 417
 None
 1.46A 3r2jC-1rf5A:
undetectable		 3r2jC-1rf5A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_D_NIOD311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 11 ASP A 419
LEU A 424
TRP A 239
TYR A 414
PHE A 417
 None
 1.47A 3r2jD-1rf5A:
undetectable		 3r2jD-1rf5A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		3 / 4 SER A 353
GLY A 387
GLU A 408
 None
 0.63A 3raeA-1rf5A:
undetectable
3raeC-1rf5A:
undetectable		 3raeA-1rf5A:
24.72
3raeC-1rf5A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 310
VAL A 292
GLY A 274
ILE A 317
ILE A 265
 None
 0.92A 3s54A-1rf5A:
undetectable		 3s54A-1rf5A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 6 PHE A 418
ASN A 411
ALA A 409
THR A 380
 None
 1.18A 3t3sB-1rf5A:
undetectable		 3t3sB-1rf5A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		3 / 3 THR A 289
ASN A 255
GLU A 280
 None
 0.62A 3v4tA-1rf5A:
32.8
3v4tC-1rf5A:
33.0		 3v4tA-1rf5A:
26.65
3v4tC-1rf5A:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		6 / 12 GLY A  30
ALA A  33
ILE A  28
ILE A  27
VAL A  71
ILE A  69
 None
 1.04A 4ax8A-1rf5A:
undetectable		 4ax8A-1rf5A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A  30
ALA A  33
ILE A  27
VAL A  71
ILE A  69
 None
 1.07A 4aztA-1rf5A:
undetectable		 4aztA-1rf5A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		6 / 12 GLY A  30
ALA A  33
ILE A  28
ILE A  27
VAL A  71
ILE A  69
 None
 1.02A 4azvA-1rf5A:
undetectable		 4azvA-1rf5A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 244
LEU A 373
LEU A 396
SER A 294
GLY A 355
 None
 0.99A 4dm8B-1rf5A:
undetectable		 4dm8B-1rf5A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 4 PRO A 146
LEU A 147
ILE A  95
ARG A  96
 None
 1.45A 4f4dA-1rf5A:
0.0		 4f4dA-1rf5A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		3 / 4 SER A 353
GLY A 387
GLU A 408
 None
 0.61A 4juoA-1rf5A:
undetectable
4juoC-1rf5A:
undetectable		 4juoA-1rf5A:
24.72
4juoC-1rf5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 8 ALA A 180
MET A 132
THR A 196
PHE A  29
 None
 1.04A 4ltwA-1rf5A:
undetectable		 4ltwA-1rf5A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		3 / 3 LEU A 147
ILE A  95
ARG A  96
 None
 0.63A 4mk4B-1rf5A:
undetectable		 4mk4B-1rf5A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WMZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 9 PHE A 238
ILE A 316
PHE A 417
GLY A 387
LEU A   3
 None
 1.41A 4wmzA-1rf5A:
undetectable		 4wmzA-1rf5A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 VAL A 216
LEU A 173
GLY A 100
VAL A 134
LEU A 155
 None
 1.08A 4y8wA-1rf5A:
undetectable		 4y8wA-1rf5A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 VAL A 216
LEU A 173
GLY A 100
VAL A 134
LEU A 155
 None
 1.10A 4y8wB-1rf5A:
undetectable		 4y8wB-1rf5A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 7 PHE A 238
ILE A 316
PHE A 417
GLY A 387
LEU A   3
 None
 1.44A 4zdzA-1rf5A:
0.0		 4zdzA-1rf5A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 7 PHE A 238
ILE A 316
PHE A 417
GLY A 387
LEU A   3
 None
 1.47A 4ze3A-1rf5A:
undetectable		 4ze3A-1rf5A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 4 LYS A 170
ASP A  19
GLU A 197
THR A 192
 None
 1.04A 5d4uA-1rf5A:
0.0		 5d4uA-1rf5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 4 LYS A 170
ASP A  19
GLU A 197
THR A 192
 None
 1.07A 5d4uB-1rf5A:
0.0		 5d4uB-1rf5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 4 LYS A 170
ASP A  19
GLU A 197
THR A 192
 None
 1.11A 5d4uC-1rf5A:
0.0		 5d4uC-1rf5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 4 LYS A 170
ASP A  19
GLU A 197
THR A 192
 None
 1.02A 5d4uD-1rf5A:
0.0		 5d4uD-1rf5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		6 / 12 ARG A 270
ASP A 312
GLY A 257
ILE A 258
ILE A 269
ILE A 265
 None
 1.43A 5e5jB-1rf5A:
undetectable		 5e5jB-1rf5A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 7 LEU A 351
THR A 322
ILE A 245
LEU A 297
 None
 1.01A 5fxtA-1rf5A:
undetectable		 5fxtA-1rf5A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 276
LEU A 240
GLU A 280
THR A 279
ALA A 288
 None
 1.28A 5ieoA-1rf5A:
undetectable		 5ieoA-1rf5A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A 186
VAL A 125
LEU A 149
GLY A 151
THR A 152
 None
 1.29A 5igpA-1rf5A:
undetectable		 5igpA-1rf5A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 7 LEU A 373
ILE A 344
MET A 365
MET A 389
 None
 1.42A 5ljcA-1rf5A:
undetectable		 5ljcA-1rf5A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A 258
GLY A 257
VAL A  16
SER A 287
ALA A 288
 None
 1.07A 5n0oB-1rf5A:
undetectable		 5n0oB-1rf5A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		6 / 12 GLY A  78
GLY A  30
GLY A  73
GLY A  75
VAL A  39
ILE A  27
 None
 1.49A 5njvC-1rf5A:
undetectable		 5njvC-1rf5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 7 LEU A 144
THR A 126
ILE A 136
LEU A 147
 None
 0.93A 5te8A-1rf5A:
undetectable		 5te8A-1rf5A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 10 ILE A 158
LEU A 178
VAL A 216
LEU A 207
GLU A 197
 None
 1.39A 5tixB-1rf5A:
undetectable		 5tixB-1rf5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		3 / 3 LEU A 207
GLN A 201
LYS A 170
 None
 0.93A 6exiB-1rf5A:
undetectable		 6exiB-1rf5A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE
(Streptococcus
pneumoniae) 		3 / 3 LEU A 207
GLN A 201
LYS A 170
 None
 0.91A 6exiA-1rf5A:
undetectable		 6exiA-1rf5A:
13.22