SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rfd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 1rfd FAB M82G2, HEAVY
CHAIN
(Mus
musculus) 		4 / 4 THR H 117
PRO H 149
THR H 116
PRO H 118
 None
 1.35A 1dsdC-1rfdH:
undetectable		 1dsdC-1rfdH:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 1rfd FAB M82G2, HEAVY
CHAIN
(Mus
musculus) 		4 / 4 THR H 117
PRO H 149
THR H 116
PRO H 118
 None
 1.35A 1dsdC-1rfdH:
undetectable		 1dsdC-1rfdH:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1rfd FAB M82G2, HEAVY
CHAIN
(Mus
musculus) 		3 / 3 SER H 216
ALA H 211
VAL H 210
 None
 0.68A 4o2bC-1rfdH:
undetectable		 4o2bC-1rfdH:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 1rfd FAB M82G2, HEAVY
CHAIN
(Mus
musculus) 		5 / 12 GLY H 100
ASN H  52
PHE H  29
TYR H 102
VAL H  78
 None
 1.42A 5d0yA-1rfdH:
undetectable		 5d0yA-1rfdH:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 1rfd FAB M82G2, HEAVY
CHAIN
(Mus
musculus) 		5 / 5 SER H 112
ALA H 114
PHE H 148
LEU H 178
ASP H 181
 None
 0.60A 5mthA-1rfdH:
26.9		 5mthA-1rfdH:
65.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 1rfd FAB M82G2, HEAVY
CHAIN
(Mus
musculus) 		3 / 3 SER H 216
ALA H 211
VAL H 210
 None
 0.50A 5xiwC-1rfdH:
undetectable		 5xiwC-1rfdH:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 1rfd FAB M82G2, HEAVY
CHAIN
(Mus
musculus) 		5 / 10 PHE H  27
TRP H  33
ASN H  53
LEU H  98
GLY H  99
 None
 1.24A 6r2eB-1rfdH:
0.0		 6r2eB-1rfdH:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 1rfd FAB M82G2, HEAVY
CHAIN
(Mus
musculus) 		5 / 10 PHE H  27
TRP H  33
ASN H  53
LEU H  98
GLY H  99
 None
 1.25A 6r2eD-1rfdH:
0.0		 6r2eD-1rfdH:
20.61