SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rfe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM5_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1rfe HYPOTHETICAL PROTEIN
RV2991
(Mycobacterium
tuberculosis) 		4 / 8 VAL A  20
TRP A  52
PHE A  73
GLU A  50
 None
 1.46A 1om5A-1rfeA:
undetectable
1om5B-1rfeA:
undetectable		 1om5A-1rfeA:
17.96
1om5B-1rfeA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1rfe HYPOTHETICAL PROTEIN
RV2991
(Mycobacterium
tuberculosis) 		4 / 8 TRP A  52
PHE A  73
GLU A  50
VAL A  20
 None
 1.39A 1rs6A-1rfeA:
undetectable
1rs6B-1rfeA:
undetectable		 1rs6A-1rfeA:
17.96
1rs6B-1rfeA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 1rfe HYPOTHETICAL PROTEIN
RV2991
(Mycobacterium
tuberculosis) 		4 / 8 PHE A  89
SER A  88
ILE A   9
THR A 142
 None
 0.77A 1sbrA-1rfeA:
undetectable		 1sbrA-1rfeA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 1rfe HYPOTHETICAL PROTEIN
RV2991
(Mycobacterium
tuberculosis) 		4 / 7 PHE A  89
SER A  88
ILE A   9
THR A 142
 None
 0.82A 1sbrB-1rfeA:
undetectable		 1sbrB-1rfeA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 1rfe HYPOTHETICAL PROTEIN
RV2991
(Mycobacterium
tuberculosis) 		4 / 6 SER A  22
SER A 144
GLN A   5
ASP A  18
 None
 1.39A 2cl5B-1rfeA:
0.0		 2cl5B-1rfeA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1rfe HYPOTHETICAL PROTEIN
RV2991
(Mycobacterium
tuberculosis) 		4 / 8 VAL A  20
TRP A  52
PHE A  73
GLU A  50
 None
 1.47A 2g6hA-1rfeA:
undetectable
2g6hB-1rfeA:
undetectable		 2g6hA-1rfeA:
18.05
2g6hB-1rfeA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 1rfe HYPOTHETICAL PROTEIN
RV2991
(Mycobacterium
tuberculosis) 		4 / 6 SER A  22
SER A 144
GLN A   5
ASP A  18
 None
 1.38A 2zvjA-1rfeA:
0.0		 2zvjA-1rfeA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 1rfe HYPOTHETICAL PROTEIN
RV2991
(Mycobacterium
tuberculosis) 		4 / 8 TRP A  52
PHE A  73
GLU A  50
VAL A  20
 None
 1.29A 3b3pA-1rfeA:
undetectable
3b3pB-1rfeA:
undetectable		 3b3pA-1rfeA:
17.96
3b3pB-1rfeA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1rfe HYPOTHETICAL PROTEIN
RV2991
(Mycobacterium
tuberculosis) 		4 / 4 ASP A  82
LEU A 152
ARG A   6
THR A  80
 None
 1.46A 4kjjA-1rfeA:
undetectable		 4kjjA-1rfeA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1rfe HYPOTHETICAL PROTEIN
RV2991
(Mycobacterium
tuberculosis) 		4 / 4 ASP A  82
LEU A 152
ARG A   6
THR A  80
 None
 1.46A 4kjkA-1rfeA:
undetectable		 4kjkA-1rfeA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1rfe HYPOTHETICAL PROTEIN
RV2991
(Mycobacterium
tuberculosis) 		4 / 5 ASP A  82
LEU A 152
ARG A   6
THR A  80
 None
 1.45A 4p3qA-1rfeA:
undetectable		 4p3qA-1rfeA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1rfe HYPOTHETICAL PROTEIN
RV2991
(Mycobacterium
tuberculosis) 		4 / 8 TRP A  52
PHE A  73
GLU A  50
VAL A  20
 None
 1.41A 4uchA-1rfeA:
undetectable
4uchB-1rfeA:
undetectable		 4uchA-1rfeA:
18.14
4uchB-1rfeA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3W_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1rfe HYPOTHETICAL PROTEIN
RV2991
(Mycobacterium
tuberculosis) 		4 / 7 TRP A  52
PHE A  73
GLU A  50
VAL A  20
 None
 1.37A 4v3wA-1rfeA:
undetectable
4v3wB-1rfeA:
undetectable		 4v3wA-1rfeA:
17.96
4v3wB-1rfeA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1rfe HYPOTHETICAL PROTEIN
RV2991
(Mycobacterium
tuberculosis) 		4 / 5 SER A  22
SER A 144
GLN A   5
ASP A  18
 None
 1.40A 5fhrB-1rfeA:
undetectable		 5fhrB-1rfeA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1rfe HYPOTHETICAL PROTEIN
RV2991
(Mycobacterium
tuberculosis) 		4 / 7 VAL A  20
TRP A  52
PHE A  73
GLU A  50
 None
 1.40A 6auuA-1rfeA:
undetectable
6auuB-1rfeA:
undetectable		 6auuA-1rfeA:
20.48
6auuB-1rfeA:
20.48