SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rfs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MBG_A_ACTA500_0 (FAD-LINKED SULFHYDRYL OXIDASE ALR)	1rfs	RIESKE PROTEIN (Spinacia oleracea)	4 / 4	ALA A 143 HIS A 109 HIS A 128 PRO A 142	None FES A 200 ( 3.3A) FES A 200 ( 3.3A) FES A 200 ( 4.6A)	1.25A	3mbgA-1rfsA: undetectable	3mbgA-1rfsA: 20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MBG_C_ACTC900_0 (FAD-LINKED SULFHYDRYL OXIDASE ALR)	1rfs	RIESKE PROTEIN (Spinacia oleracea)	4 / 4	ALA A 143 HIS A 109 HIS A 128 PRO A 142	None FES A 200 ( 3.3A) FES A 200 ( 3.3A) FES A 200 ( 4.6A)	1.25A	3mbgC-1rfsA: undetectable	3mbgC-1rfsA: 20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5E26_D_PAUD601_0 (PANTOTHENATE KINASE 2, MITOCHONDRIAL)	1rfs	RIESKE PROTEIN (Spinacia oleracea)	4 / 8	VAL A 63 ALA A 55 GLY A 82 GLY A 102	None	0.89A	5e26C-1rfsA: undetectable 5e26D-1rfsA: undetectable	5e26C-1rfsA: 18.50 5e26D-1rfsA: 18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UUN_B_ACTB307_0 (GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN)	1rfs	RIESKE PROTEIN (Spinacia oleracea)	3 / 3	LEU A 98 ALA A 99 LEU A 69	None	0.32A	5uunB-1rfsA: undetectable	5uunB-1rfsA: 20.82

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3MBG_A_ACTA500_0","FAD-LINKED SULFHYDRYL OXIDASE ALR","1rfs","RIESKE PROTEIN","Spinacia oleracea",4,"ALA A 143;HIS A 109;HIS A 128;PRO A 142","None;FES A 200 ( 3.3A);FES A 200 ( 3.3A);FES A 200 ( 4.6A)","1.25A","3mbgA-1rfsA:undetectable","3mbgA-1rfsA:20.92"],["3MBG_C_ACTC900_0","FAD-LINKED SULFHYDRYL OXIDASE ALR","1rfs","RIESKE PROTEIN","Spinacia oleracea",4,"ALA A 143;HIS A 109;HIS A 128;PRO A 142","None;FES A 200 ( 3.3A);FES A 200 ( 3.3A);FES A 200 ( 4.6A)","1.25A","3mbgC-1rfsA:undetectable","3mbgC-1rfsA:20.92"],["5E26_D_PAUD601_0","PANTOTHENATE KINASE 2, MITOCHONDRIAL","1rfs","RIESKE PROTEIN","Spinacia oleracea",4,"VAL A  63;ALA A  55;GLY A  82;GLY A 102","None","0.89A","5e26C-1rfsA:undetectable;5e26D-1rfsA:undetectable","5e26C-1rfsA:18.50;5e26D-1rfsA:18.50"],["5UUN_B_ACTB307_0","GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN","1rfs","RIESKE PROTEIN","Spinacia oleracea",3,"LEU A  98;ALA A  99;LEU A  69","None","0.32A","5uunB-1rfsA:undetectable","5uunB-1rfsA:20.82"]]