SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rfz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 1rfz HYPOTHETICAL PROTEIN
APC35681
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A  51
ALA A 152
ILE A  64
LEU A  17
ILE A  55
 None
 0.96A 1d1gB-1rfzA:
undetectable		 1d1gB-1rfzA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 1rfz HYPOTHETICAL PROTEIN
APC35681
(Geobacillus
stearothermophil
us) 		5 / 9 ILE A 104
GLY A  67
ILE A  68
ILE A  55
ILE A 149
 None
 0.95A 1hshB-1rfzA:
undetectable		 1hshB-1rfzA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 1rfz HYPOTHETICAL PROTEIN
APC35681
(Geobacillus
stearothermophil
us) 		5 / 9 LEU A 157
VAL A  54
ILE A 104
GLY A 147
ILE A 119
 None
 1.11A 3ekqB-1rfzA:
undetectable		 3ekqB-1rfzA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1rfz HYPOTHETICAL PROTEIN
APC35681
(Geobacillus
stearothermophil
us) 		5 / 10 ILE A 126
ILE A  27
VAL A  51
TYR A 116
LEU A 142
 None
 1.23A 3elzC-1rfzA:
undetectable		 3elzC-1rfzA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 1rfz HYPOTHETICAL PROTEIN
APC35681
(Geobacillus
stearothermophil
us) 		5 / 12 VAL A  60
ILE A  55
LEU A  30
VAL A 105
ILE A 104
 None
 0.98A 3em6B-1rfzA:
undetectable		 3em6B-1rfzA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1rfz HYPOTHETICAL PROTEIN
APC35681
(Geobacillus
stearothermophil
us) 		4 / 8 ASP A  90
ASP A  71
ASP A 120
ASP A 144
 None
 1.19A 4feuF-1rfzA:
undetectable		 4feuF-1rfzA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 1rfz HYPOTHETICAL PROTEIN
APC35681
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 104
ALA A 151
ILE A 119
LEU A 130
ILE A 145
 None
 1.10A 4km0B-1rfzA:
undetectable		 4km0B-1rfzA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 1rfz HYPOTHETICAL PROTEIN
APC35681
(Geobacillus
stearothermophil
us) 		5 / 9 LEU A 157
VAL A  54
ILE A 104
GLY A 147
ILE A 119
 None
 1.12A 5kqxB-1rfzA:
undetectable		 5kqxB-1rfzA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1rfz HYPOTHETICAL PROTEIN
APC35681
(Geobacillus
stearothermophil
us) 		3 / 3 TYR A 118
ALA A 150
LEU A  30
 None
 0.68A 6ag0C-1rfzA:
undetectable		 6ag0C-1rfzA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1rfz HYPOTHETICAL PROTEIN
APC35681
(Geobacillus
stearothermophil
us) 		5 / 11 VAL A  51
ALA A 153
LEU A  17
ALA A 150
LEU A  30
 None
 1.49A 6dk1B-1rfzA:
undetectable		 6dk1B-1rfzA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1rfz HYPOTHETICAL PROTEIN
APC35681
(Geobacillus
stearothermophil
us) 		4 / 7 VAL A 107
GLY A 125
ARG A  53
ALA A 150
 None
None
SO4  A 401 (-4.3A)
None
 0.82A 6hd6B-1rfzA:
undetectable		 6hd6B-1rfzA:
19.31