SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rgy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		4 / 6 GLN A 120
TYR A 221
VAL A 211
GLY A 214
 PTX  A 400 ( 3.1A)
PTX  A 400 (-3.7A)
None
None
 1.11A 1ekjC-1rgyA:
undetectable
1ekjD-1rgyA:
undetectable		 1ekjC-1rgyA:
19.78
1ekjD-1rgyA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		4 / 8 SER A 324
VAL A  65
SER A  64
ASN A 152
 None
None
PTX  A 400 (-1.5A)
PTX  A 400 (-3.6A)
 1.26A 1hwkA-1rgyA:
undetectable		 1hwkA-1rgyA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		4 / 8 SER A 324
VAL A  65
SER A  64
ASN A 152
 None
None
PTX  A 400 (-1.5A)
PTX  A 400 (-3.6A)
 1.25A 1hwkD-1rgyA:
undetectable		 1hwkD-1rgyA:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		6 / 10 GLY A  63
GLN A 120
ASN A 152
TYR A 221
THR A 316
GLY A 317
 PTX  A 400 ( 3.9A)
PTX  A 400 ( 3.1A)
PTX  A 400 (-3.6A)
PTX  A 400 (-3.7A)
None
PTX  A 400 (-3.3A)
 1.22A 1kvlA-1rgyA:
62.5		 1kvlA-1rgyA:
76.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		8 / 10 LEU A 119
GLN A 120
TYR A 150
ASN A 152
TYR A 221
LYS A 315
THR A 316
GLY A 317
 None
PTX  A 400 ( 3.1A)
PTX  A 400 (-4.7A)
PTX  A 400 (-3.6A)
PTX  A 400 (-3.7A)
PTX  A 400 ( 4.5A)
None
PTX  A 400 (-3.3A)
 0.27A 1kvlA-1rgyA:
62.5		 1kvlA-1rgyA:
76.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		6 / 12 ALA A 110
GLY A  74
GLY A  75
LEU A  85
LEU A 254
LEU A 106
 None
 1.20A 1ya4A-1rgyA:
undetectable		 1ya4A-1rgyA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		4 / 5 VAL A  12
ASN A  13
VAL A  30
ILE A  32
 None
 1.05A 1z2bC-1rgyA:
undetectable		 1z2bC-1rgyA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		4 / 5 TYR A 170
MET A 174
THR A 175
LEU A 179
 None
 0.91A 2eimJ-1rgyA:
0.0		 2eimJ-1rgyA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		4 / 5 TYR A 170
MET A 174
THR A 175
LEU A 179
 None
 0.86A 2eimW-1rgyA:
undetectable		 2eimW-1rgyA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		5 / 12 LEU A  62
ILE A 155
GLY A  71
VAL A  72
VAL A 223
 None
 0.88A 2o4lB-1rgyA:
undetectable		 2o4lB-1rgyA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		4 / 8 PHE A 158
LEU A 106
ARG A  80
GLY A  74
 None
 0.83A 2vdbA-1rgyA:
0.0		 2vdbA-1rgyA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		4 / 7 VAL A 329
LYS A 332
TRP A 312
GLU A 358
 None
 1.14A 3hs4A-1rgyA:
undetectable		 3hs4A-1rgyA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		5 / 12 LYS A  67
ASN A 152
LYS A 315
THR A 316
GLY A 317
 PTX  A 400 ( 4.0A)
PTX  A 400 (-3.6A)
PTX  A 400 ( 4.5A)
None
PTX  A 400 (-3.3A)
 0.34A 3huoA-1rgyA:
15.0		 3huoA-1rgyA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		6 / 12 SER A  64
LYS A  67
ASN A 152
GLY A 317
THR A 319
ARG A 349
 PTX  A 400 (-1.5A)
PTX  A 400 ( 4.0A)
PTX  A 400 (-3.6A)
PTX  A 400 (-3.3A)
None
None
 1.03A 3mzeA-1rgyA:
14.7		 3mzeA-1rgyA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		6 / 12 SER A  64
LYS A  67
ASN A 152
THR A 316
GLY A 317
THR A 319
 PTX  A 400 (-1.5A)
PTX  A 400 ( 4.0A)
PTX  A 400 (-3.6A)
None
PTX  A 400 (-3.3A)
None
 0.75A 3mzeA-1rgyA:
14.7		 3mzeA-1rgyA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		5 / 10 LEU A  62
ILE A 155
GLY A  71
VAL A  72
VAL A 223
 None
 0.89A 3oxwC-1rgyA:
undetectable		 3oxwC-1rgyA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		5 / 11 LEU A  62
ILE A 155
GLY A  71
VAL A  72
VAL A 223
 None
 0.82A 3oxxD-1rgyA:
undetectable		 3oxxD-1rgyA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		5 / 12 GLY A 268
ALA A 110
TRP A 271
LEU A 269
SER A 311
 None
 1.05A 3p2kD-1rgyA:
undetectable		 3p2kD-1rgyA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		4 / 6 LEU A  73
LEU A 184
PRO A 181
LEU A 179
 None
 0.84A 3q1eA-1rgyA:
0.0
3q1eC-1rgyA:
0.0		 3q1eA-1rgyA:
14.29
3q1eC-1rgyA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		5 / 9 LEU A  85
ALA A 162
GLY A 156
ILE A 155
LEU A 107
 None
 0.99A 3u7sA-1rgyA:
undetectable		 3u7sA-1rgyA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FH2_A_0RNA303_1
(BETA-LACTAMASE SHV-1)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		5 / 10 ASN A 152
LYS A 315
THR A 316
GLY A 317
ARG A 349
 PTX  A 400 (-3.6A)
PTX  A 400 ( 4.5A)
None
PTX  A 400 (-3.3A)
None
 1.23A 4fh2A-1rgyA:
15.2		 4fh2A-1rgyA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		5 / 8 ALA A 352
ALA A 353
ILE A 356
ALA A  29
PHE A  41
 None
 1.25A 4v1fA-1rgyA:
undetectable
4v1fB-1rgyA:
undetectable		 4v1fA-1rgyA:
14.17
4v1fB-1rgyA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		4 / 7 VAL A  12
ASN A  13
ILE A  16
VAL A  30
 None
 0.78A 5bmvC-1rgyA:
undetectable		 5bmvC-1rgyA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		4 / 5 SER A 257
ALA A 307
MET A 273
LEU A 254
 None
 1.45A 5dzkb-1rgyA:
undetectable
5dzkp-1rgyA:
undetectable		 5dzkb-1rgyA:
19.45
5dzkp-1rgyA:
1.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		4 / 5 SER A 257
ALA A 307
MET A 273
LEU A 254
 None
 1.43A 5dzkc-1rgyA:
undetectable
5dzkq-1rgyA:
undetectable		 5dzkc-1rgyA:
19.45
5dzkq-1rgyA:
1.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		6 / 12 LEU A  85
GLY A  74
ALA A 162
GLY A 156
ILE A 155
SER A 105
 None
 1.33A 5t2zB-1rgyA:
undetectable		 5t2zB-1rgyA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		4 / 5 TYR A 170
MET A 174
THR A 175
LEU A 179
 None
 0.78A 5w97J-1rgyA:
0.0		 5w97J-1rgyA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 1rgy BETA-LACTAMASE
(Citrobacter
freundii) 		4 / 6 GLN A 267
VAL A 313
LEU A 107
PRO A 304
 None
 1.17A 6brdB-1rgyA:
undetectable		 6brdB-1rgyA:
15.92