SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rh1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 1rh1 COLICIN B
(Escherichia
coli) 		4 / 5 LEU A 110
LEU A 106
LEU A 171
GLY A 186
 None
 1.01A 1a4lC-1rh1A:
undetectable		 1a4lC-1rh1A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 1rh1 COLICIN B
(Escherichia
coli) 		5 / 12 ALA A 492
ILE A 373
PHE A 464
LEU A 382
MET A 377
 None
 1.00A 1dtlA-1rh1A:
0.0		 1dtlA-1rh1A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 1rh1 COLICIN B
(Escherichia
coli) 		4 / 7 MET A 444
PHE A 464
ALA A 495
ILE A 373
 None
 1.07A 1fxhA-1rh1A:
undetectable
1fxhB-1rh1A:
0.0		 1fxhA-1rh1A:
16.70
1fxhB-1rh1A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_C_BEZC1162_0
(PEROXIREDOXIN 5)		 1rh1 COLICIN B
(Escherichia
coli) 		5 / 9 PRO A 120
GLY A 258
ARG A 119
THR A  18
GLY A  16
 None
 1.40A 1h4oC-1rh1A:
undetectable
1h4oD-1rh1A:
undetectable		 1h4oC-1rh1A:
15.76
1h4oD-1rh1A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_E_BEZE1162_0
(PEROXIREDOXIN 5)		 1rh1 COLICIN B
(Escherichia
coli) 		5 / 9 PRO A 120
GLY A 258
ARG A 119
THR A  18
GLY A  16
 None
 1.40A 1h4oE-1rh1A:
0.0
1h4oF-1rh1A:
0.0		 1h4oE-1rh1A:
15.76
1h4oF-1rh1A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 1rh1 COLICIN B
(Escherichia
coli) 		4 / 7 ALA A 495
PHE A 464
TRP A 440
LEU A 376
 None
 1.14A 2hzqA-1rh1A:
undetectable		 2hzqA-1rh1A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 1rh1 COLICIN B
(Escherichia
coli) 		4 / 4 LEU A 505
ILE A 351
ILE A 493
ALA A 492
 None
 0.85A 2i30A-1rh1A:
2.0		 2i30A-1rh1A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 1rh1 COLICIN B
(Escherichia
coli) 		4 / 7 VAL A  99
SER A 100
ARG A 103
PRO A  66
 None
 1.07A 2v2gA-1rh1A:
undetectable
2v2gB-1rh1A:
undetectable		 2v2gA-1rh1A:
18.45
2v2gB-1rh1A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 1rh1 COLICIN B
(Escherichia
coli) 		4 / 8 VAL A  99
SER A 100
ARG A 103
PRO A  66
 None
 0.95A 2v41C-1rh1A:
undetectable
2v41D-1rh1A:
undetectable		 2v41C-1rh1A:
18.45
2v41D-1rh1A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 1rh1 COLICIN B
(Escherichia
coli) 		4 / 8 PRO A  66
VAL A  99
SER A 100
ARG A 103
 None
 1.02A 2v41C-1rh1A:
undetectable
2v41D-1rh1A:
undetectable		 2v41C-1rh1A:
18.45
2v41D-1rh1A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 1rh1 COLICIN B
(Escherichia
coli) 		4 / 7 PRO A  66
VAL A  99
SER A 100
ARG A 103
 None
 1.07A 2v41E-1rh1A:
undetectable
2v41F-1rh1A:
undetectable		 2v41E-1rh1A:
18.45
2v41F-1rh1A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_A_BEZA1162_0
(PEROXIREDOXIN-5)		 1rh1 COLICIN B
(Escherichia
coli) 		5 / 10 PRO A 120
GLY A 258
ARG A 119
THR A  18
GLY A  16
 None
 1.42A 2vl2A-1rh1A:
0.0
2vl2C-1rh1A:
undetectable		 2vl2A-1rh1A:
17.12
2vl2C-1rh1A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y4N_B_PACB503_0
(PHENYLACETATE-COENZY
ME A LIGASE)		 1rh1 COLICIN B
(Escherichia
coli) 		4 / 4 SER A 478
GLY A 486
GLY A 337
LYS A 335
 None
 1.32A 2y4nB-1rh1A:
undetectable		 2y4nB-1rh1A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 1rh1 COLICIN B
(Escherichia
coli) 		4 / 8 LEU A 227
GLN A  61
MET A 142
ILE A  57
 None
 0.90A 3cldB-1rh1A:
2.1		 3cldB-1rh1A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 1rh1 COLICIN B
(Escherichia
coli) 		6 / 10 ARG A 349
ALA A 490
GLY A 469
ILE A 473
ALA A 352
ILE A 351
 None
 1.48A 3ekwA-1rh1A:
undetectable		 3ekwA-1rh1A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 1rh1 COLICIN B
(Escherichia
coli) 		4 / 6 LEU A 289
GLU A 287
ASN A 264
SER A 293
 None
 1.49A 3i9jB-1rh1A:
2.0		 3i9jB-1rh1A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 1rh1 COLICIN B
(Escherichia
coli) 		5 / 10 LEU A 461
ALA A 492
PHE A 496
GLY A 494
ILE A 497
 None
 0.99A 3qpsA-1rh1A:
1.5		 3qpsA-1rh1A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1rh1 COLICIN B
(Escherichia
coli) 		5 / 12 ILE A 493
LEU A 463
PHE A 464
LEU A 443
THR A 325
 None
 1.03A 4ej1B-1rh1A:
undetectable		 4ej1B-1rh1A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1rh1 COLICIN B
(Escherichia
coli) 		4 / 6 ASN A 303
GLU A 299
GLU A 301
TYR A 259
 None
 1.18A 4mi4A-1rh1A:
undetectable		 4mi4A-1rh1A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1rh1 COLICIN B
(Escherichia
coli) 		4 / 7 ASN A 303
GLU A 299
GLU A 301
TYR A 259
 None
 1.19A 4mi4A-1rh1A:
0.0
4mi4C-1rh1A:
undetectable		 4mi4A-1rh1A:
16.50
4mi4C-1rh1A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1rh1 COLICIN B
(Escherichia
coli) 		4 / 8 ASN A 303
GLU A 299
GLU A 301
TYR A 259
 None
 1.16A 4mj8A-1rh1A:
undetectable
4mj8C-1rh1A:
undetectable		 4mj8A-1rh1A:
15.55
4mj8C-1rh1A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1rh1 COLICIN B
(Escherichia
coli) 		4 / 7 ASN A 303
GLU A 299
GLU A 301
TYR A 259
 None
 1.11A 4mj8C-1rh1A:
undetectable		 4mj8C-1rh1A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1rh1 COLICIN B
(Escherichia
coli) 		5 / 12 LEU A 461
ILE A 329
GLY A 494
ALA A 492
ILE A 427
 None
 0.94A 4nkxB-1rh1A:
undetectable		 4nkxB-1rh1A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 1rh1 COLICIN B
(Escherichia
coli) 		5 / 12 VAL A 481
TYR A 344
LEU A 340
GLY A 483
ILE A 489
 None
 1.28A 4o5fA-1rh1A:
undetectable
4o5fB-1rh1A:
undetectable		 4o5fA-1rh1A:
21.75
4o5fB-1rh1A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 1rh1 COLICIN B
(Escherichia
coli) 		5 / 12 VAL A 481
TYR A 344
LEU A 340
GLY A 483
ILE A 489
 None
 1.29A 4o5fA-1rh1A:
undetectable
4o5fB-1rh1A:
undetectable		 4o5fA-1rh1A:
21.75
4o5fB-1rh1A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1rh1 COLICIN B
(Escherichia
coli) 		5 / 12 ILE A 493
ALA A 460
PHE A 464
LEU A 443
THR A 325
 None
 0.90A 4psyA-1rh1A:
undetectable		 4psyA-1rh1A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 1rh1 COLICIN B
(Escherichia
coli) 		3 / 3 MET A 261
GLN A 176
TYR A 181
 None
 0.92A 4udcA-1rh1A:
undetectable		 4udcA-1rh1A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 1rh1 COLICIN B
(Escherichia
coli) 		6 / 12 LEU A 158
VAL A 165
GLY A 162
ALA A 161
ILE A 269
PRO A 280
 None
 1.47A 4xdrA-1rh1A:
0.0		 4xdrA-1rh1A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 1rh1 COLICIN B
(Escherichia
coli) 		5 / 12 VAL A 268
ALA A 216
VAL A 270
LEU A  64
ILE A 138
 None
 1.17A 5hv1A-1rh1A:
0.0		 5hv1A-1rh1A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1rh1 COLICIN B
(Escherichia
coli) 		5 / 11 LEU A 110
GLY A 113
LEU A 106
GLU A 256
ALA A 121
 None
 1.02A 5o96G-1rh1A:
undetectable		 5o96G-1rh1A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1rh1 COLICIN B
(Escherichia
coli) 		3 / 3 GLY A 494
VAL A 447
MET A 444
 None
 0.57A 5ycpA-1rh1A:
undetectable		 5ycpA-1rh1A:
9.23