SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rhc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 7 LEU A 170
THR A  74
GLN A  52
MET A  57
 None
 1.25A 1kglA-1rhcA:
undetectable		 1kglA-1rhcA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6I_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 7 MET A 282
VAL A 232
PHE A 321
GLU A 293
 None
 1.42A 1p6iA-1rhcA:
0.0
1p6iB-1rhcA:
undetectable		 1p6iA-1rhcA:
20.14
1p6iB-1rhcA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_D_URFD999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 4 MET A  57
ALA A  60
TYR A  96
ILE A  69
 None
 1.48A 1upfD-1rhcA:
undetectable		 1upfD-1rhcA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 6 TYR A   7
TYR A 230
ILE A 320
ILE A 318
 None
 1.24A 2dcfA-1rhcA:
undetectable		 2dcfA-1rhcA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		5 / 12 VAL A 104
GLY A 105
GLY A 107
THR A 129
ALA A 132
 None
F42  A 351 ( 4.0A)
F42  A 351 (-3.2A)
None
None
 0.72A 2egvB-1rhcA:
3.7		 2egvB-1rhcA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6K_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 7 PHE A 321
GLU A 293
MET A 282
VAL A 232
 None
 1.42A 2g6kA-1rhcA:
undetectable
2g6kB-1rhcA:
undetectable		 2g6kA-1rhcA:
19.41
2g6kB-1rhcA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_1
(HYPOTHETICAL PROTEIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 4 GLY A 107
GLU A 108
ASP A  38
TYR A  80
 F42  A 351 (-3.2A)
ACN  A 352 ( 2.9A)
None
None
 1.27A 2yvlC-1rhcA:
1.3		 2yvlC-1rhcA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 7 MET A 282
VAL A 232
PHE A 321
GLU A 293
 None
 1.47A 3fc5A-1rhcA:
undetectable
3fc5B-1rhcA:
undetectable		 3fc5A-1rhcA:
19.26
3fc5B-1rhcA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC5_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 7 PHE A 321
GLU A 293
MET A 282
VAL A 232
 None
 1.46A 3fc5A-1rhcA:
undetectable
3fc5B-1rhcA:
undetectable		 3fc5A-1rhcA:
19.26
3fc5B-1rhcA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		5 / 12 LEU A 250
GLY A 248
GLN A 266
TYR A 281
ILE A 277
 None
 0.96A 3gwwA-1rhcA:
0.0		 3gwwA-1rhcA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 7 PHE A 321
GLU A 293
MET A 282
VAL A 232
 None
 1.41A 3jx0A-1rhcA:
undetectable
3jx0B-1rhcA:
undetectable		 3jx0A-1rhcA:
19.91
3jx0B-1rhcA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLZ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 7 PHE A 321
GLU A 293
MET A 282
VAL A 232
 None
 1.45A 3nlzA-1rhcA:
undetectable
3nlzB-1rhcA:
undetectable		 3nlzA-1rhcA:
20.14
3nlzB-1rhcA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		5 / 12 ALA A 103
VAL A  36
LEU A  61
TRP A  56
ALA A  23
 None
 1.32A 3ozuA-1rhcA:
undetectable		 3ozuA-1rhcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQJ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 7 PHE A 321
GLU A 293
MET A 282
VAL A 232
 None
 1.43A 3rqjA-1rhcA:
undetectable
3rqjB-1rhcA:
undetectable		 3rqjA-1rhcA:
20.14
3rqjB-1rhcA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TX2_A_BEZA251_0
(PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 7 ARG A 244
ALA A 247
TRP A 246
ALA A 269
 None
None
CL  A 392 (-4.3A)
None
 1.20A 3tx2A-1rhcA:
undetectable		 3tx2A-1rhcA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 5 THR A  74
ILE A  73
GLU A 108
PHE A   8
 None
F42  A 351 (-4.2A)
ACN  A 352 ( 2.9A)
None
 1.05A 4ac9C-1rhcA:
2.0		 4ac9C-1rhcA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 5 THR A  74
ILE A  73
GLU A 108
PHE A   8
 None
F42  A 351 (-4.2A)
ACN  A 352 ( 2.9A)
None
 1.06A 4acaC-1rhcA:
2.6		 4acaC-1rhcA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 5 THR A  74
ILE A  73
GLU A 108
PHE A   8
 None
F42  A 351 (-4.2A)
ACN  A 352 ( 2.9A)
None
 1.08A 4acbC-1rhcA:
2.3		 4acbC-1rhcA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		3 / 3 GLY A 101
SER A  70
TRP A  35
 None
 0.92A 4e7cD-1rhcA:
0.0		 4e7cD-1rhcA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVZ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 7 MET A 282
VAL A 232
PHE A 321
GLU A 293
 None
 1.43A 4fvzA-1rhcA:
undetectable
4fvzB-1rhcA:
undetectable		 4fvzA-1rhcA:
20.14
4fvzB-1rhcA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		5 / 12 ALA A 194
HIS A  39
GLU A  12
PHE A 255
GLU A 108
 None
ACN  A 352 ( 4.0A)
ACN  A 352 ( 4.4A)
F42  A 351 (-4.9A)
ACN  A 352 ( 2.9A)
 1.27A 4r7lA-1rhcA:
undetectable		 4r7lA-1rhcA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3U_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 7 PHE A 321
GLU A 293
MET A 282
VAL A 232
 None
 1.45A 4v3uA-1rhcA:
undetectable
4v3uB-1rhcA:
undetectable		 4v3uA-1rhcA:
20.53
4v3uB-1rhcA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3U_C_H4BC760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 7 MET A 282
VAL A 232
PHE A 321
GLU A 293
 None
 1.42A 4v3uC-1rhcA:
0.5
4v3uD-1rhcA:
undetectable		 4v3uC-1rhcA:
20.53
4v3uD-1rhcA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 7 MET A 282
VAL A 232
PHE A 321
GLU A 293
 None
 1.42A 4v3yA-1rhcA:
undetectable
4v3yB-1rhcA:
undetectable		 4v3yA-1rhcA:
20.14
4v3yB-1rhcA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGK_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 7 MET A 282
VAL A 232
PHE A 321
GLU A 293
 None
 1.43A 5agkA-1rhcA:
undetectable
5agkB-1rhcA:
0.1		 5agkA-1rhcA:
20.14
5agkB-1rhcA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 6 LEU A 170
THR A  74
GLN A  52
MET A  57
 None
 1.35A 5h8tA-1rhcA:
0.0		 5h8tA-1rhcA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 7 GLY A 105
GLY A 107
THR A 129
ALA A 132
 F42  A 351 ( 4.0A)
F42  A 351 (-3.2A)
None
None
 0.76A 5o96C-1rhcA:
3.7		 5o96C-1rhcA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		3 / 3 TYR A 230
ALA A  26
TYR A   7
 None
 0.84A 5uunB-1rhcA:
0.0		 5uunB-1rhcA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		5 / 9 VAL A  36
GLY A 105
VAL A 104
GLY A 107
PRO A  76
 None
F42  A 351 ( 4.0A)
None
F42  A 351 (-3.2A)
None
 1.29A 5zniA-1rhcA:
undetectable		 5zniA-1rhcA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		5 / 12 GLN A 126
GLY A 179
VAL A 203
GLY A 105
SER A 173
 F42  A 351 (-3.6A)
F42  A 351 (-3.7A)
None
F42  A 351 ( 4.0A)
F42  A 351 (-2.5A)
 0.98A 6c2mB-1rhcA:
undetectable		 6c2mB-1rhcA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 5 LEU A 139
THR A 154
PRO A  76
ARG A  79
 None
None
None
F42  A 351 ( 4.9A)
 1.21A 6ew0B-1rhcA:
0.7		 6ew0B-1rhcA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 5 LEU A 139
THR A 154
PRO A  76
ARG A  79
 None
None
None
F42  A 351 ( 4.9A)
 1.21A 6ew0D-1rhcA:
0.8		 6ew0D-1rhcA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 5 LEU A 139
THR A 154
PRO A  76
ARG A  79
 None
None
None
F42  A 351 ( 4.9A)
 1.21A 6ew0H-1rhcA:
0.9		 6ew0H-1rhcA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 5 LEU A 139
THR A 154
PRO A  76
ARG A  79
 None
None
None
F42  A 351 ( 4.9A)
 1.21A 6ew0I-1rhcA:
0.6		 6ew0I-1rhcA:
13.78