SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rhy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBK_A_RAPA225_1
(FKBP25)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		5 / 12 GLY A  99
ILE A 181
ALA A  88
ILE A  21
PHE A 148
 None
 1.00A 1pbkA-1rhyA:
undetectable		 1pbkA-1rhyA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		5 / 7 ARG A 182
ILE A 181
LEU A  81
GLY A  82
PHE A  85
 None
 1.15A 1rtsB-1rhyA:
undetectable		 1rtsB-1rhyA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		5 / 11 GLY A  82
ALA A  84
PHE A  85
ALA A  88
LEU A  23
 None
 1.08A 1ukbA-1rhyA:
undetectable		 1ukbA-1rhyA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		5 / 8 ARG A 182
ILE A 181
LEU A  81
GLY A  82
PHE A  85
 None
 1.43A 2tsrB-1rhyA:
undetectable		 2tsrB-1rhyA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_A_478A200_1
(HIV-1 PROTEASE)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		4 / 6 GLU A 164
PRO A 104
ARG A 162
GLY A 163
 None
 1.26A 3oxvA-1rhyA:
undetectable		 3oxvA-1rhyA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		5 / 12 ALA A 151
LEU A  81
LEU A  50
LEU A 177
ILE A 181
 None
 0.90A 3uvvA-1rhyA:
0.0		 3uvvA-1rhyA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		5 / 12 LEU A 144
LEU A 145
LEU A 126
SER A 160
VAL A 133
 None
 1.14A 4f4dB-1rhyA:
undetectable		 4f4dB-1rhyA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		5 / 12 LEU A 156
LEU A 145
LEU A 144
ALA A  78
MET A  46
 None
 1.32A 4fn9B-1rhyA:
undetectable		 4fn9B-1rhyA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		4 / 7 ILE A 181
LEU A  81
GLY A  82
PHE A  85
 None
 0.80A 4iqqA-1rhyA:
undetectable		 4iqqA-1rhyA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		4 / 7 ILE A 181
LEU A  81
GLY A  82
PHE A  85
 None
 0.72A 4iqqB-1rhyA:
undetectable		 4iqqB-1rhyA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		4 / 7 ILE A 181
LEU A  81
GLY A  82
PHE A  85
 None
 0.70A 4iqqC-1rhyA:
undetectable		 4iqqC-1rhyA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		4 / 8 ILE A 181
LEU A  81
GLY A  82
PHE A  85
 None
 0.83A 4iqqD-1rhyA:
undetectable		 4iqqD-1rhyA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		5 / 9 PHE A 122
ALA A 149
ALA A 151
SER A 142
LEU A 145
 EMC  A5501 (-4.3A)
None
None
None
None
 1.28A 4or0A-1rhyA:
undetectable		 4or0A-1rhyA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		5 / 9 ALA A  49
THR A  48
GLY A  55
GLY A  54
ALA A 178
 None
 1.06A 4qvmK-1rhyA:
undetectable
4qvmL-1rhyA:
undetectable		 4qvmK-1rhyA:
20.89
4qvmL-1rhyA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		5 / 10 ALA A  49
THR A  48
GLY A  55
GLY A  54
ALA A 178
 None
 1.06A 4qw3K-1rhyA:
undetectable
4qw3L-1rhyA:
undetectable		 4qw3K-1rhyA:
19.27
4qw3L-1rhyA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		5 / 10 ALA A  49
THR A  48
GLY A  55
GLY A  54
ALA A 178
 None
 1.06A 4qw3Y-1rhyA:
undetectable
4qw3Z-1rhyA:
undetectable		 4qw3Y-1rhyA:
19.27
4qw3Z-1rhyA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		5 / 12 GLN A  32
ALA A 178
ILE A 181
ILE A  34
LEU A  58
 None
 1.19A 4r3aA-1rhyA:
undetectable		 4r3aA-1rhyA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		5 / 11 ALA A   6
GLU A  83
LEU A  81
LEU A  60
LEU A  58
 None
 1.10A 4wg0G-1rhyA:
undetectable
4wg0H-1rhyA:
undetectable
4wg0I-1rhyA:
undetectable		 4wg0G-1rhyA:
5.73
4wg0H-1rhyA:
5.73
4wg0I-1rhyA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		5 / 9 ALA A  49
THR A  48
GLY A  55
GLY A  54
ALA A 178
 None
 1.06A 5d0xK-1rhyA:
undetectable
5d0xL-1rhyA:
undetectable		 5d0xK-1rhyA:
21.36
5d0xL-1rhyA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		5 / 9 ALA A  49
THR A  48
GLY A  55
GLY A  54
ALA A 178
 None
 1.06A 5d0xY-1rhyA:
undetectable
5d0xZ-1rhyA:
undetectable		 5d0xY-1rhyA:
21.36
5d0xZ-1rhyA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		5 / 9 MET A  56
VAL A 154
LEU A 156
ILE A 114
LEU A  43
 None
 1.41A 5iepA-1rhyA:
0.6		 5iepA-1rhyA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		5 / 11 ALA A  49
THR A  48
GLY A  55
GLY A  54
ALA A 178
 None
 1.04A 5lf3Y-1rhyA:
undetectable
5lf3Z-1rhyA:
undetectable		 5lf3Y-1rhyA:
21.66
5lf3Z-1rhyA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		4 / 7 ILE A 181
LEU A  81
GLY A  82
PHE A  85
 None
 0.81A 5nooA-1rhyA:
undetectable		 5nooA-1rhyA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		4 / 7 ILE A 181
LEU A  81
GLY A  82
PHE A  85
 None
 0.81A 5nooB-1rhyA:
undetectable		 5nooB-1rhyA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		4 / 8 ILE A 181
LEU A  81
GLY A  82
PHE A  85
 None
 0.87A 5nooD-1rhyA:
undetectable		 5nooD-1rhyA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1rhy IMIDAZOLE GLYCEROL
PHOSPHATE
DEHYDRATASE
(Cryptococcus
neoformans) 		3 / 3 LEU A 177
ALA A 176
LEU A 145
 None
 0.50A 5uunB-1rhyA:
undetectable		 5uunB-1rhyA:
22.18