SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ri6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 1ri6 PUTATIVE ISOMERASE
YBHE
(Escherichia
coli) 		5 / 12 ILE A 292
LEU A 313
HIS A 286
TYR A 246
ILE A 255
 None
 1.09A 1fmlB-1ri6A:
undetectable		 1fmlB-1ri6A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1ri6 PUTATIVE ISOMERASE
YBHE
(Escherichia
coli) 		5 / 12 ILE A 306
LEU A 291
HIS A 286
LEU A  28
ILE A 292
 None
 1.27A 1kyvD-1ri6A:
undetectable
1kyvE-1ri6A:
undetectable		 1kyvD-1ri6A:
17.99
1kyvE-1ri6A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1ri6 PUTATIVE ISOMERASE
YBHE
(Escherichia
coli) 		4 / 5 GLY A 324
GLN A 323
VAL A 321
SER A 298
 None
 1.41A 1p6kB-1ri6A:
undetectable		 1p6kB-1ri6A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1ri6 PUTATIVE ISOMERASE
YBHE
(Escherichia
coli) 		5 / 12 ILE A  89
HIS A 237
ASP A 235
HIS A 182
GLY A 281
 None
 1.15A 1zz1B-1ri6A:
undetectable
1zz1C-1ri6A:
undetectable		 1zz1B-1ri6A:
21.98
1zz1C-1ri6A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 1ri6 PUTATIVE ISOMERASE
YBHE
(Escherichia
coli) 		4 / 5 ASP A  48
SER A  46
LEU A 117
GLY A 116
 None
 1.08A 2j2pA-1ri6A:
undetectable
2j2pB-1ri6A:
0.9		 2j2pA-1ri6A:
20.57
2j2pB-1ri6A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1ri6 PUTATIVE ISOMERASE
YBHE
(Escherichia
coli) 		6 / 12 GLY A 322
GLY A 281
GLY A 295
GLY A 324
GLU A 276
VAL A 328
 None
 1.20A 2oxtD-1ri6A:
undetectable		 2oxtD-1ri6A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YHD_A_TESA1920_1
(ANDROGEN RECEPTOR)		 1ri6 PUTATIVE ISOMERASE
YBHE
(Escherichia
coli) 		5 / 12 LEU A 291
LEU A 312
GLY A 311
GLN A 310
THR A 239
 None
 1.15A 2yhdA-1ri6A:
undetectable		 2yhdA-1ri6A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 1ri6 PUTATIVE ISOMERASE
YBHE
(Escherichia
coli) 		5 / 12 CYH A 131
GLY A 130
GLY A 106
SER A 102
GLY A 101
 None
 0.80A 3huoB-1ri6A:
undetectable		 3huoB-1ri6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 1ri6 PUTATIVE ISOMERASE
YBHE
(Escherichia
coli) 		4 / 4 SER A 302
TYR A 304
GLY A 295
PRO A 325
 None
 1.41A 4e3aA-1ri6A:
undetectable		 4e3aA-1ri6A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1ri6 PUTATIVE ISOMERASE
YBHE
(Escherichia
coli) 		4 / 6 THR A  75
GLN A  96
LEU A 113
GLU A 114
 None
 1.25A 4nc3A-1ri6A:
undetectable		 4nc3A-1ri6A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 1ri6 PUTATIVE ISOMERASE
YBHE
(Escherichia
coli) 		5 / 12 LEU A 313
THR A 239
ILE A 255
ALA A 293
PHE A 282
 None
 1.25A 4rp8C-1ri6A:
undetectable		 4rp8C-1ri6A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 1ri6 PUTATIVE ISOMERASE
YBHE
(Escherichia
coli) 		3 / 3 ASP A 285
VAL A 303
LEU A  28
 None
 0.62A 5e5jB-1ri6A:
undetectable		 5e5jB-1ri6A:
13.04