SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rie'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 1rie RIESKE IRON-SULFUR
PROTEIN
(Bos
taurus) 		4 / 7 CYH A 158
TYR A 157
TYR A 165
CYH A 139
 FES  A 200 ( 2.2A)
None
None
FES  A 200 ( 2.2A)
 1.33A 1yvmA-1rieA:
undetectable		 1yvmA-1rieA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_B_CHDB304_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 1rie RIESKE IRON-SULFUR
PROTEIN
(Bos
taurus) 		5 / 10 GLN A 108
GLU A 105
ARG A 172
PHE A 153
GLY A 151
 None
 1.30A 2dysA-1rieA:
undetectable
2dysB-1rieA:
0.1
2dysT-1rieA:
0.0		 2dysA-1rieA:
12.32
2dysB-1rieA:
18.70
2dysT-1rieA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_B_CHDB1086_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 1rie RIESKE IRON-SULFUR
PROTEIN
(Bos
taurus) 		5 / 10 GLN A 108
GLU A 105
ARG A 172
PHE A 153
GLY A 151
 None
 1.35A 2eijA-1rieA:
undetectable
2eijB-1rieA:
0.1
2eijT-1rieA:
0.0		 2eijA-1rieA:
12.32
2eijB-1rieA:
18.70
2eijT-1rieA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_B_CHDB1086_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 1rie RIESKE IRON-SULFUR
PROTEIN
(Bos
taurus) 		5 / 10 GLN A 108
GLU A 105
ARG A 172
PHE A 153
GLY A 151
 None
 1.33A 2eikA-1rieA:
undetectable
2eikB-1rieA:
0.1
2eikT-1rieA:
0.0		 2eikA-1rieA:
12.32
2eikB-1rieA:
18.70
2eikT-1rieA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_B_CHDB1086_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 1rie RIESKE IRON-SULFUR
PROTEIN
(Bos
taurus) 		5 / 10 GLN A 108
GLU A 105
ARG A 172
PHE A 153
GLY A 151
 None
 1.34A 2eilA-1rieA:
undetectable
2eilB-1rieA:
0.1
2eilT-1rieA:
0.0		 2eilA-1rieA:
12.32
2eilB-1rieA:
18.70
2eilT-1rieA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_B_CHDB1086_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 1rie RIESKE IRON-SULFUR
PROTEIN
(Bos
taurus) 		5 / 10 GLN A 108
GLU A 105
ARG A 172
PHE A 153
GLY A 151
 None
 1.32A 2eimA-1rieA:
undetectable
2eimB-1rieA:
0.2
2eimT-1rieA:
0.0		 2eimA-1rieA:
12.32
2eimB-1rieA:
18.70
2eimT-1rieA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_B_CHDB1086_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 1rie RIESKE IRON-SULFUR
PROTEIN
(Bos
taurus) 		5 / 10 GLN A 108
GLU A 105
ARG A 172
PHE A 153
GLY A 151
 None
 1.35A 2einA-1rieA:
undetectable
2einB-1rieA:
0.2
2einT-1rieA:
0.0		 2einA-1rieA:
12.32
2einB-1rieA:
18.70
2einT-1rieA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_B_CHDB1086_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 1rie RIESKE IRON-SULFUR
PROTEIN
(Bos
taurus) 		5 / 11 GLN A 108
GLU A 105
ARG A 172
PHE A 153
GLY A 151
 None
 1.44A 3abmA-1rieA:
undetectable
3abmB-1rieA:
0.1
3abmT-1rieA:
0.0		 3abmA-1rieA:
12.32
3abmB-1rieA:
18.70
3abmT-1rieA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 1rie RIESKE IRON-SULFUR
PROTEIN
(Bos
taurus) 		5 / 11 GLN A 108
GLU A 105
ARG A 172
PHE A 153
GLY A 151
 None
 1.40A 3ag1A-1rieA:
undetectable
3ag1B-1rieA:
0.2
3ag1T-1rieA:
0.0		 3ag1A-1rieA:
12.32
3ag1B-1rieA:
18.70
3ag1T-1rieA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 1rie RIESKE IRON-SULFUR
PROTEIN
(Bos
taurus) 		5 / 11 GLN A 108
GLU A 105
ARG A 172
PHE A 153
GLY A 151
 None
 1.42A 3asnA-1rieA:
undetectable
3asnB-1rieA:
0.1
3asnT-1rieA:
0.0		 3asnA-1rieA:
12.32
3asnB-1rieA:
18.70
3asnT-1rieA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 1rie RIESKE IRON-SULFUR
PROTEIN
(Bos
taurus) 		5 / 11 GLN A 108
GLU A 105
ARG A 172
PHE A 153
GLY A 151
 None
 1.39A 3asoA-1rieA:
undetectable
3asoB-1rieA:
0.1
3asoT-1rieA:
0.0		 3asoA-1rieA:
12.32
3asoB-1rieA:
18.70
3asoT-1rieA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA500_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 1rie RIESKE IRON-SULFUR
PROTEIN
(Bos
taurus) 		4 / 4 ALA A 176
HIS A 141
HIS A 161
PRO A 175
 None
FES  A 200 ( 3.2A)
FES  A 200 ( 3.2A)
FES  A 200 ( 4.9A)
 1.37A 3mbgA-1rieA:
undetectable		 3mbgA-1rieA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC900_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 1rie RIESKE IRON-SULFUR
PROTEIN
(Bos
taurus) 		4 / 4 ALA A 176
HIS A 141
HIS A 161
PRO A 175
 None
FES  A 200 ( 3.2A)
FES  A 200 ( 3.2A)
FES  A 200 ( 4.9A)
 1.37A 3mbgC-1rieA:
undetectable		 3mbgC-1rieA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 1rie RIESKE IRON-SULFUR
PROTEIN
(Bos
taurus) 		3 / 3 PRO A 183
TYR A 185
GLY A 196
 None
 0.75A 4g2zA-1rieA:
undetectable		 4g2zA-1rieA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 1rie RIESKE IRON-SULFUR
PROTEIN
(Bos
taurus) 		5 / 10 GLY A 155
TYR A 156
GLY A 169
SER A 168
ARG A 101
 None
 1.42A 5hwkA-1rieA:
undetectable		 5hwkA-1rieA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 1rie RIESKE IRON-SULFUR
PROTEIN
(Bos
taurus) 		5 / 10 GLY A 155
TYR A 156
GLY A 169
SER A 168
ARG A 101
 None
 1.41A 5hwkB-1rieA:
0.0		 5hwkB-1rieA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1rie RIESKE IRON-SULFUR
PROTEIN
(Bos
taurus) 		4 / 7 LEU A 180
VAL A 182
ASN A  86
VAL A 133
 None
 1.11A 5jh7C-1rieA:
undetectable		 5jh7C-1rieA:
15.56