SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rif'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 1rif DNA HELICASE UVSW
(Escherichia
virus
T4) 		4 / 8 ALA A 237
GLY A 257
ILE A 132
ILE A 242
 None
None
AU  A 287 ( 4.7A)
None
 0.70A 1d4yB-1rifA:
undetectable		 1d4yB-1rifA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 1rif DNA HELICASE UVSW
(Escherichia
virus
T4) 		5 / 8 ALA A 237
GLY A 257
ILE A 132
ILE A 246
ILE A 242
 None
None
AU  A 287 ( 4.7A)
None
None
 1.48A 1hshD-1rifA:
undetectable		 1hshD-1rifA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 1rif DNA HELICASE UVSW
(Escherichia
virus
T4) 		5 / 12 CYH A  17
ASP A  55
ILE A  68
PHE A  71
ALA A  79
 None
None
AU  A 285 (-4.6A)
None
AU  A 285 (-3.5A)
 1.04A 1oltA-1rifA:
0.2		 1oltA-1rifA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 1rif DNA HELICASE UVSW
(Escherichia
virus
T4) 		4 / 8 ALA A 174
ALA A 146
ARG A 150
LEU A 143
 None
 0.82A 2bxmA-1rifA:
undetectable		 2bxmA-1rifA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 1rif DNA HELICASE UVSW
(Escherichia
virus
T4) 		5 / 12 GLY A 274
ILE A  51
ILE A 269
ALA A 237
ILE A 242
 None
 0.88A 2nmzB-1rifA:
undetectable		 2nmzB-1rifA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1rif DNA HELICASE UVSW
(Escherichia
virus
T4) 		4 / 6 ILE A 144
ILE A 188
LEU A 133
MET A 230
 None
 1.00A 3adsA-1rifA:
undetectable		 3adsA-1rifA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 1rif DNA HELICASE UVSW
(Escherichia
virus
T4) 		5 / 10 ALA A 174
ILE A 162
GLY A 210
ALA A 205
ILE A 188
 None
 1.00A 3ekwA-1rifA:
undetectable		 3ekwA-1rifA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1rif DNA HELICASE UVSW
(Escherichia
virus
T4) 		3 / 3 ILE A  15
PHE A  22
HIS A  12
 None
 0.70A 3h0aA-1rifA:
undetectable		 3h0aA-1rifA:
22.58