SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1rii'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 1rii 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 179
LEU A  56
ILE A  46
ARG A  77
 None
 0.80A 2rlfC-1riiA:
undetectable
2rlfD-1riiA:
undetectable		 2rlfC-1riiA:
11.11
2rlfD-1riiA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1rii 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 180
ALA A 182
PHE A 160
ARG A 159
LEU A  88
 None
 1.02A 3dzuA-1riiA:
undetectable		 3dzuA-1riiA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1rii 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 180
ALA A 182
PHE A 160
ARG A 159
LEU A  88
 None
 1.08A 3dzyA-1riiA:
undetectable		 3dzyA-1riiA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 1rii 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 THR A  58
ALA A 182
LEU A 187
LEU A 190
LEU A 179
 None
 1.29A 4xi3D-1riiA:
undetectable		 4xi3D-1riiA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1rii 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 210
ILE A 211
THR A 229
GLY A 228
GLY A 227
 None
 0.92A 5koxA-1riiA:
undetectable		 5koxA-1riiA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 1rii 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 217
PHE A 164
LEU A   9
ILE A 180
 None
 0.94A 5mzjA-1riiA:
undetectable		 5mzjA-1riiA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1rii 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 207
GLY A 184
HIS A 183
PHE A 160
VAL A 156
 None
None
GOL  A 501 ( 4.6A)
None
None
 1.07A 5n0rA-1riiA:
undetectable		 5n0rA-1riiA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1rii 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 207
GLY A 184
HIS A 183
PHE A 160
VAL A 156
 None
None
GOL  A 501 ( 4.6A)
None
None
 1.07A 5n0tB-1riiA:
undetectable		 5n0tB-1riiA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1rii 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 207
GLY A 184
HIS A 183
PHE A 160
VAL A 156
 None
None
GOL  A 501 ( 4.6A)
None
None
 1.08A 5n0wA-1riiA:
3.2		 5n0wA-1riiA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1rii 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 207
GLY A 184
HIS A 183
PHE A 160
VAL A 156
 None
None
GOL  A 501 ( 4.6A)
None
None
 1.09A 5n0wB-1riiA:
3.9		 5n0wB-1riiA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1rii 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Mycobacterium
tuberculosis) 		6 / 10 LEU A   7
GLY A   5
GLY A 175
VAL A  55
LEU A 179
ARG A  77
 None
 1.45A 5o96E-1riiA:
undetectable
5o96F-1riiA:
undetectable		 5o96E-1riiA:
22.70
5o96F-1riiA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1rii 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 180
TYR A 163
ARG A  87
THR A 165
 None
 1.29A 5z84N-1riiA:
undetectable
5z84W-1riiA:
undetectable		 5z84N-1riiA:
18.79
5z84W-1riiA:
11.70